Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis - Zohny, Sohir M.; Habib, Mohamed Z.; Mohamad, Magda I.; Elayat, Wael M.; Elhossiny, Reham M.; El-Salam, Mohamed F. Abd; Hassan, Ghada A.M.; Aboul-Fotouh, Sawsan (Neurotherapeutics, 2023)
Keywords: Animal models; Animals; Apoptosis; Aripiprazole; Aripiprazole - adverse effects; Astrocyte; Autism; Autism spectrum disorder; Autism Spectrum Disorder - chemically induced; Autism Spectrum Disorder - drug therapy; Autistic Disorder - chemically induced; Autistic Disorder - drug therapy; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - metabolism; Cognitive ability; Cognitive dysfunction; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - complications; Cognitive Dysfunction - drug therapy; Cyclic AMP response element-binding protein; Disease Models, Animal; Female; gamma-Aminobutyric Acid - pharmacology; Gene expression; Glutamate; Glutamatergic transmission; Glutamates - adverse effects; Glutamic acid transporter; Hippocampus; Homeostasis; Male; Maze learning; Memantine; Memantine - adverse effects; Neurobiology; Neurofibrillary tangles; Neurology; Neurosciences; Neurosurgery; Original; Original Article; Pregnancy; Protein structure; Proteins; Rats; Rats, Wistar; Sodium valproate; Spatial discrimination learning; Stereotyped behavior; Therapeutic targets; Valproic Acid; γ-Aminobutyric acid; Memantine; Astrocyte; Aripiprazole; Glutamate; Autism spectrum disorder; Cognitive dysfunction