Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis
Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role...
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| Published in | Neurotherapeutics Vol. 20; no. 2; pp. 464 - 483 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Cham
Elsevier Inc
01.03.2023
Springer International Publishing Springer Nature B.V |
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| Abstract | Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role of chronic memantine (20 mg/kg/day) and aripiprazole (3 mg/kg/day) combination therapy in the management of prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits in male Wistar rats. Pregnant female rats received a single intraperitoneal injection of VPA (600 mg/kg) to induce autistic-like behaviors in their offspring. Prenatal VPA induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in Morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and gene expression of glutamate transporter-1 (Glt-1) with a decline in GABA/glutamate ratio (both measured by HPLC). These were accompanied by the appearance of numerous neurofibrillary tangles (NFTs) with enhanced apoptosis in hippocampal sections. Memantine/aripiprazole combination increased the protein levels of p-CREB, BDNF, and Glt-1 gene expression with restoration of GABA/glutamate balance, attenuation of VPA-induced neurodegenerative changes and autistic-like symptoms, and improvement of cognitive performance. This study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing CREB/BDNF signaling with increased expression of astrocytic Glt-1 and restoration of GABA/glutamate balance, leading to inhibition of hippocampal NFTs formation and neuronal apoptosis. |
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| AbstractList | SummarySignificant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role of chronic memantine (20 mg/kg/day) and aripiprazole (3 mg/kg/day) combination therapy in the management of prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits in male Wistar rats. Pregnant female rats received a single intraperitoneal injection of VPA (600 mg/kg) to induce autistic-like behaviors in their offspring. Prenatal VPA induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in Morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and gene expression of glutamate transporter-1 (Glt-1) with a decline in GABA/glutamate ratio (both measured by HPLC). These were accompanied by the appearance of numerous neurofibrillary tangles (NFTs) with enhanced apoptosis in hippocampal sections. Memantine/aripiprazole combination increased the protein levels of p-CREB, BDNF, and Glt-1 gene expression with restoration of GABA/glutamate balance, attenuation of VPA-induced neurodegenerative changes and autistic-like symptoms, and improvement of cognitive performance. This study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing CREB/BDNF signaling with increased expression of astrocytic Glt-1 and restoration of GABA/glutamate balance, leading to inhibition of hippocampal NFTs formation and neuronal apoptosis. Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role of chronic memantine (20 mg/kg/day) and aripiprazole (3 mg/kg/day) combination therapy in the management of prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits in male Wistar rats. Pregnant female rats received a single intraperitoneal injection of VPA (600 mg/kg) to induce autistic-like behaviors in their offspring. Prenatal VPA induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in Morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and gene expression of glutamate transporter-1 (Glt-1) with a decline in GABA/glutamate ratio (both measured by HPLC). These were accompanied by the appearance of numerous neurofibrillary tangles (NFTs) with enhanced apoptosis in hippocampal sections. Memantine/aripiprazole combination increased the protein levels of p-CREB, BDNF, and Glt-1 gene expression with restoration of GABA/glutamate balance, attenuation of VPA-induced neurodegenerative changes and autistic-like symptoms, and improvement of cognitive performance. This study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing CREB/BDNF signaling with increased expression of astrocytic Glt-1 and restoration of GABA/glutamate balance, leading to inhibition of hippocampal NFTs formation and neuronal apoptosis.Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role of chronic memantine (20 mg/kg/day) and aripiprazole (3 mg/kg/day) combination therapy in the management of prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits in male Wistar rats. Pregnant female rats received a single intraperitoneal injection of VPA (600 mg/kg) to induce autistic-like behaviors in their offspring. Prenatal VPA induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in Morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and gene expression of glutamate transporter-1 (Glt-1) with a decline in GABA/glutamate ratio (both measured by HPLC). These were accompanied by the appearance of numerous neurofibrillary tangles (NFTs) with enhanced apoptosis in hippocampal sections. Memantine/aripiprazole combination increased the protein levels of p-CREB, BDNF, and Glt-1 gene expression with restoration of GABA/glutamate balance, attenuation of VPA-induced neurodegenerative changes and autistic-like symptoms, and improvement of cognitive performance. This study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing CREB/BDNF signaling with increased expression of astrocytic Glt-1 and restoration of GABA/glutamate balance, leading to inhibition of hippocampal NFTs formation and neuronal apoptosis. Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role of chronic memantine (20 mg/kg/day) and aripiprazole (3 mg/kg/day) combination therapy in the management of prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits in male Wistar rats. Pregnant female rats received a single intraperitoneal injection of VPA (600 mg/kg) to induce autistic-like behaviors in their offspring. Prenatal VPA induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in Morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and gene expression of glutamate transporter-1 (Glt-1) with a decline in GABA/glutamate ratio (both measured by HPLC). These were accompanied by the appearance of numerous neurofibrillary tangles (NFTs) with enhanced apoptosis in hippocampal sections. Memantine/aripiprazole combination increased the protein levels of p-CREB, BDNF, and Glt-1 gene expression with restoration of GABA/glutamate balance, attenuation of VPA-induced neurodegenerative changes and autistic-like symptoms, and improvement of cognitive performance. This study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing CREB/BDNF signaling with increased expression of astrocytic Glt-1 and restoration of GABA/glutamate balance, leading to inhibition of hippocampal NFTs formation and neuronal apoptosis. Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role of chronic memantine (20 mg/kg/day) and aripiprazole (3 mg/kg/day) combination therapy in the management of prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits in male Wistar rats. Pregnant female rats received a single intraperitoneal injection of VPA (600 mg/kg) to induce autistic-like behaviors in their offspring. Prenatal VPA induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in Morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and gene expression of glutamate transporter-1 (Glt-1) with a decline in GABA/glutamate ratio (both measured by HPLC). These were accompanied by the appearance of numerous neurofibrillary tangles (NFTs) with enhanced apoptosis in hippocampal sections. Memantine/aripiprazole combination increased the protein levels of p-CREB, BDNF, and Glt-1 gene expression with restoration of GABA/glutamate balance, attenuation of VPA-induced neurodegenerative changes and autistic-like symptoms, and improvement of cognitive performance. This study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing CREB/BDNF signaling with increased expression of astrocytic Glt-1 and restoration of GABA/glutamate balance, leading to inhibition of hippocampal NFTs formation and neuronal apoptosis. Summary Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role of chronic memantine (20 mg/kg/day) and aripiprazole (3 mg/kg/day) combination therapy in the management of prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits in male Wistar rats. Pregnant female rats received a single intraperitoneal injection of VPA (600 mg/kg) to induce autistic-like behaviors in their offspring. Prenatal VPA induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in Morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and gene expression of glutamate transporter-1 ( Glt-1 ) with a decline in GABA/glutamate ratio (both measured by HPLC). These were accompanied by the appearance of numerous neurofibrillary tangles (NFTs) with enhanced apoptosis in hippocampal sections. Memantine/aripiprazole combination increased the protein levels of p-CREB, BDNF, and Glt-1 gene expression with restoration of GABA/glutamate balance, attenuation of VPA-induced neurodegenerative changes and autistic-like symptoms, and improvement of cognitive performance. This study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing CREB/BDNF signaling with increased expression of astrocytic Glt-1 and restoration of GABA/glutamate balance, leading to inhibition of hippocampal NFTs formation and neuronal apoptosis. Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant glutamatergic transmission in the pathogenesis of ASD-associated cellular and behavioral deficits. This study aimed at investigating the role of chronic memantine (20 mg/kg/day) and aripiprazole (3 mg/kg/day) combination therapy in the management of prenatal sodium valproate (VPA)-induced autistic-like/cognitive deficits in male Wistar rats. Pregnant female rats received a single intraperitoneal injection of VPA (600 mg/kg) to induce autistic-like behaviors in their offspring. Prenatal VPA induced autistic-like symptoms (decreased social interaction and the appearance of stereotyped behavior) with deficits in spatial learning (in Morris water maze) and cognitive flexibility (in the attentional set-shifting task) in addition to decreased hippocampal protein levels of phosphorylated cAMP response element-binding protein (p-CREB), brain-derived neurotrophic factor (BDNF), and gene expression of glutamate transporter-1 ( Glt-1 ) with a decline in GABA/glutamate ratio (both measured by HPLC). These were accompanied by the appearance of numerous neurofibrillary tangles (NFTs) with enhanced apoptosis in hippocampal sections. Memantine/aripiprazole combination increased the protein levels of p-CREB, BDNF, and Glt-1 gene expression with restoration of GABA/glutamate balance, attenuation of VPA-induced neurodegenerative changes and autistic-like symptoms, and improvement of cognitive performance. This study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing CREB/BDNF signaling with increased expression of astrocytic Glt-1 and restoration of GABA/glutamate balance, leading to inhibition of hippocampal NFTs formation and neuronal apoptosis. |
| Author | Elhossiny, Reham M. El-Salam, Mohamed F. Abd Zohny, Sohir M. Elayat, Wael M. Habib, Mohamed Z. Mohamad, Magda I. Aboul-Fotouh, Sawsan Hassan, Ghada A.M. |
| Author_xml | – sequence: 1 givenname: Sohir M. surname: Zohny fullname: Zohny, Sohir M. organization: Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Abbassia, 11566, Cairo, Egypt – sequence: 2 givenname: Mohamed Z. orcidid: 0000-0001-7161-8121 surname: Habib fullname: Habib, Mohamed Z. email: Mohamed.habib@med.asu.edu.eg organization: Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Abbassia, 11566, Cairo, Egypt – sequence: 3 givenname: Magda I. surname: Mohamad fullname: Mohamad, Magda I. organization: Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt – sequence: 4 givenname: Wael M. surname: Elayat fullname: Elayat, Wael M. organization: Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt – sequence: 5 givenname: Reham M. surname: Elhossiny fullname: Elhossiny, Reham M. organization: Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt – sequence: 6 givenname: Mohamed F. Abd surname: El-Salam fullname: El-Salam, Mohamed F. Abd organization: Physiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt – sequence: 7 givenname: Ghada A.M. surname: Hassan fullname: Hassan, Ghada A.M. organization: Neuropsychiatry Department, Faculty of Medicine, Galala University, Al Galala, Egypt – sequence: 8 givenname: Sawsan surname: Aboul-Fotouh fullname: Aboul-Fotouh, Sawsan organization: Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Abbassia, 11566, Cairo, Egypt |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36918475$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1515/revneuro-2014-0056 10.1038/tp.2016.161 10.1002/aur.2696 10.1007/BF02704114 10.9758/cpn.2019.17.3.400 10.1016/j.bbr.2013.04.043 10.1007/s00213-017-4703-9 10.1152/physrev.00041.2013 10.1038/srep42528 10.1016/j.acthis.2019.08.002 10.3389/fncel.2019.00357 10.3389/fncel.2016.00021 10.1007/s10567-012-0119-6 10.1002/smll.201701808 10.1016/j.pnpbp.2020.110185 10.1089/cap.2006.16.517 10.1007/s00401-016-1553-1 10.1038/sj.npp.1300518 10.1016/j.brainresbull.2016.03.013 10.1038/sj.npp.1301615 10.1017/S1461145712001216 10.1523/JNEUROSCI.1069-16.2016 10.1084/jem.20140413 10.3389/fphar.2018.01185 10.3892/mmr.2015.4321 10.4331/wjbc.v8.i1.21 10.1006/meth.2001.1262 10.1074/jbc.M113.483826 10.1089/cap.2021.0010 10.1038/s41398-020-00904-4 10.1016/j.neuro.2020.12.016 10.1371/journal.pone.0246068 10.1016/j.nurt.2010.04.001 10.1007/s12640-012-9354-3 10.1089/cap.2020.0014 10.1038/nprot.2006.20 10.1177/0883073807302611 10.1016/j.neuint.2016.04.010 10.1016/j.pharep.2017.12.007 10.1016/j.ejphar.2019.172454 10.9734/INDJ/2015/12118 10.3390/ijms23042125 10.1016/j.neuropharm.2007.07.013 10.1007/s00213-015-4128-2 10.1017/S1461145712000880 10.1016/j.ejphar.2022.175046 10.1016/j.brainres.2012.11.048 10.3390/ijms232112734 10.3389/fnmol.2015.00017 10.1038/npp.2015.26 10.1016/j.neuint.2009.06.003 10.1016/j.neuint.2010.05.010 10.3233/JAD-2011-110503 10.1016/0003-2697(76)90527-3 10.1111/fcp.12316 10.1016/j.jinorgbio.2004.02.010 10.2217/phe.10.45 10.1111/j.1476-5381.2012.02057.x 10.1016/j.bbr.2020.112906 10.1111/j.1460-9568.2005.04290.x 10.1016/j.neuint.2020.104932 10.1016/j.pnpbp.2022.110522 10.1113/jphysiol.2002.038729 10.1016/j.ejphar.2020.173411 10.1016/j.neulet.2011.04.044 10.4103/jrms.JRMS_209_19 10.1002/hup.2841 |
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| Keywords | Memantine Astrocyte Aripiprazole Glutamate Autism spectrum disorder Cognitive dysfunction |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 2023. The Author(s). Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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| ORCID | 0000-0001-7161-8121 |
| OpenAccessLink | https://link.springer.com/10.1007/s13311-023-01360-w |
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| PublicationDate | March 2023 20230300 2023-03-00 20230301 |
| PublicationDateYYYYMMDD | 2023-03-01 |
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| PublicationSubtitle | The Journal of the American Society for Experimental Neurotherapeutics |
| PublicationTitle | Neurotherapeutics |
| PublicationTitleAbbrev | Neurotherapeutics |
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| PublicationYear | 2023 |
| Publisher | Elsevier Inc Springer International Publishing Springer Nature B.V |
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| References | Mohamed, Habib, Ebeid (bib40) 2020; 885 Parsons, Stöffler, Danysz (bib67) 2007; 53 Choi, Im, Park (bib36) 2019; 17 Zeidan, Fombonne, Scorah (bib3) 2022; 15 Aida, Yoshida, Nomura (bib12) 2015; 40 Russo, Albert, Judith (bib58) 2017; 5 (bib2) 2013 Mookherjee, Green, Watson (bib48) 2011; 26 Karst, Van Hecke (bib45) 2012; 15 Habib, Tadros, Abd-Alkhalek (bib41) 2022; 927 Gonçalves-Ribeiro, Pina, Sebastião (bib7) 2019; 13 Ramandi, Elahdadi Salmani, Moghimi (bib10) 2021; 16 Livak, Schmittgen (bib43) 2001; 25 Wang, Hausknecht, Shen (bib54) 2018; 9 Struzyńska, Sulkowski (bib47) 2004; 98 Owley, Salt, Guter (bib29) 2006; 16 Bristot Silvestrin, Bambini-Junior, Galland (bib11) 2013; 1495 Petrelli, Pucci, Bezzi (bib1) 2016; 10 Danysz, Parsons (bib25) 2012; 167 Sánchez-López, Egea, Davis (bib62) 2018; 14 Lin, Chang, Chiu (bib19) 2022; 23 Segnitz, Schmitt, Gebicke-Härter (bib70) 2009; 55 Elnaiem, Benmelouka, Elgendy (bib68) 2022 Arafat, Shabaan (bib61) 2019; 121 Blankenship, Erickson, Stigler (bib5) 2010; 4 John, Wu, Kodama (bib44) 2003; 548 Bhat, Acharya, Adeli (bib6) 2014; 25 Kerr, Downey, Conboy (bib37) 2013; 249 Elliott, Atlas, Lange (bib20) 2005; 22 Soorya, Fogg, Ocampo (bib32) 2021; 31 Kang, Kim (bib26) 2015; 8 Liu, Wang, Xie (bib15) 2016; 233 Takahashi, Kong, Lin (bib57) 2015; 212 Elnahas, Abuelezz, Mohamad (bib34) 2022; 116 Fu, Feng, Shao (bib17) 2019; 19 Bradford (bib42) 1976; 72 Sahu, Nag, Swain (bib50) 2017; 8 Rimmele, Rosenberg (bib51) 2016; 98 Wang, Luan, Yang (bib52) 2011; 497 Rogóż, Kamińska, Lech (bib72) 2022; 23 Banerjee, García-Oscos, Roychowdhury (bib53) 2013; 16 Meisner, Scheller, Kneitz (bib71) 2008; 33 Higashimori, Schin, Chiang (bib13) 2016; 36 Coustals, Ménard, Cohen (bib22) 2021; 31 Ebeid, Habib, Mohamed (bib38) 2021; 83 Chez, Burton, Dowling (bib30) 2007; 22 Meng, Wang, Song (bib64) 2019; 17 Erickson, Stigler, Posey (bib23) 2010; 7 Deacon (bib39) 2006; 1 Accessed 31 Jan 2023. Oustad, Najafi, Mehvari (bib65) 2020; 25 Lu, Lin, Wang (bib66) 2010; 57 Centers for Disease Control and Prevention. Key findings: CDC releases first estimates of the number of adults living with autism spectrum disorder in the United States. Available at D'Cruz, Mosconi, Ragozzino, Cook, Sweeney (bib46) 2016; 6 Pickering, Morel (bib63) 2018; 32 Lin, Lin, Tao (bib18) 2015; 12 Elnahas, Abuelezz, Mohamad (bib55) 2021; 108 Hara, Ago, Taruta (bib69) 2017; 234 Spratt, Granholm, Carpenter (bib60) 2015; 3 Lee, Park, Heo (bib24) 2019; 857 Karki, Webb, Smith (bib14) 2013; 288 Ghaleiha, Asadabadi, Mohammadi (bib31) 2013; 16 Amidfar, Kim, Wiborg (bib35) 2018; 70 Mishra, Hidau, Rai (bib28) 2021; 142 Schneider, Przewłocki (bib33) 2005; 30 Nwaobi, Cuddapah, Patterson (bib49) 2016; 132 Kumar, Sharma (bib27) 2016; 124 Essa, Braidy, Vijayan (bib8) 2013; 23 Jia, Wininger, Peyton (bib56) 2021; 396 Grigg, Ivashko-Pachima, Hait (bib21) 2020; 10 Pekny, Pekna (bib9) 2014; 94 Nair, Vaidya (bib16) 2006; 31 Serita, Fukushima, Kida (bib59) 2017; 7 Blankenship, Erickson, Stigler (CR5) 2010; 4 Meng, Wang, Song (CR64) 2019; 17 Lin, Chang, Chiu (CR19) 2022; 23 D'Cruz, Mosconi, Ragozzino, Cook, Sweeney (CR46) 2016; 6 Jia, Wininger, Peyton (CR56) 2021; 396 Sánchez-López, Egea, Davis (CR62) 2018; 14 Ebeid, Habib, Mohamed (CR38) 2021; 83 Oustad, Najafi, Mehvari (CR65) 2020; 25 Petrelli, Pucci, Bezzi (CR1) 2016; 10 Higashimori, Schin, Chiang (CR13) 2016; 36 Soorya, Fogg, Ocampo (CR32) 2021; 31 Karki, Webb, Smith (CR14) 2013; 288 Nair, Vaidya (CR16) 2006; 31 Takahashi, Kong, Lin (CR57) 2015; 212 Parsons, Stöffler, Danysz (CR67) 2007; 53 Struzyńska, Sulkowski (CR47) 2004; 98 CR2 Schneider, Przewłocki (CR33) 2005; 30 CR4 Pickering, Morel (CR63) 2018; 32 Bristot Silvestrin, Bambini-Junior, Galland (CR11) 2013; 1495 Gonçalves-Ribeiro, Pina, Sebastião (CR7) 2019; 13 Pekny, Pekna (CR9) 2014; 94 Lin, Lin, Tao (CR18) 2015; 12 Wang, Luan, Yang (CR52) 2011; 497 Segnitz, Schmitt, Gebicke-Härter (CR70) 2009; 55 Mookherjee, Green, Watson (CR48) 2011; 26 Banerjee, García-Oscos, Roychowdhury (CR53) 2013; 16 Rimmele, Rosenberg (CR51) 2016; 98 Owley, Salt, Guter (CR29) 2006; 16 Bradford (CR42) 1976; 72 Arafat, Shabaan (CR61) 2019; 121 Lu, Lin, Wang (CR66) 2010; 57 John, Wu, Kodama (CR44) 2003; 548 Erickson, Stigler, Posey (CR23) 2010; 7 Elnahas, Abuelezz, Mohamad (CR55) 2021; 108 Liu, Wang, Xie (CR15) 2016; 233 Livak, Schmittgen (CR43) 2001; 25 Chez, Burton, Dowling (CR30) 2007; 22 Deacon (CR39) 2006; 1 Fu, Feng, Shao (CR17) 2019; 19 Serita, Fukushima, Kida (CR59) 2017; 7 Russo, Albert, Judith (CR58) 2017; 5 Ghaleiha, Asadabadi, Mohammadi (CR31) 2013; 16 Meisner, Scheller, Kneitz (CR71) 2008; 33 Kumar, Sharma (CR27) 2016; 124 Coustals, Ménard, Cohen (CR22) 2021; 31 Elnahas, Abuelezz, Mohamad (CR34) 2022; 116 Zeidan, Fombonne, Scorah (CR3) 2022; 15 Elliott, Atlas, Lange (CR20) 2005; 22 Amidfar, Kim, Wiborg (CR35) 2018; 70 Essa, Braidy, Vijayan (CR8) 2013; 23 Mohamed, Habib, Ebeid (CR40) 2020; 885 Karst, Van Hecke (CR45) 2012; 15 Kang, Kim (CR26) 2015; 8 Spratt, Granholm, Carpenter (CR60) 2015; 3 Lee, Park, Heo (CR24) 2019; 857 Sahu, Nag, Swain (CR50) 2017; 8 CR68 Bhat, Acharya, Adeli (CR6) 2014; 25 Danysz, Parsons (CR25) 2012; 167 Grigg, Ivashko-Pachima, Hait (CR21) 2020; 10 Nwaobi, Cuddapah, Patterson (CR49) 2016; 132 Ramandi, Elahdadi Salmani, Moghimi (CR10) 2021; 16 Aida, Yoshida, Nomura (CR12) 2015; 40 Mishra, Hidau, Rai (CR28) 2021; 142 Hara, Ago, Taruta (CR69) 2017; 234 Kerr, Downey, Conboy (CR37) 2013; 249 Habib, Tadros, Abd-Alkhalek (CR41) 2022; 927 Choi, Im, Park (CR36) 2019; 17 Wang, Hausknecht, Shen (CR54) 2018; 9 Rogóż, Kamińska, Lech (CR72) 2022; 23 Schneider (10.1007/s13311-023-01360-w_bib33) 2005; 30 Meng (10.1007/s13311-023-01360-w_bib64) 2019; 17 Parsons (10.1007/s13311-023-01360-w_bib67) 2007; 53 Ebeid (10.1007/s13311-023-01360-w_bib38) 2021; 83 Gonçalves-Ribeiro (10.1007/s13311-023-01360-w_bib7) 2019; 13 Rogóż (10.1007/s13311-023-01360-w_bib72) 2022; 23 (10.1007/s13311-023-01360-w_bib2) 2013 Elliott (10.1007/s13311-023-01360-w_bib20) 2005; 22 Lee (10.1007/s13311-023-01360-w_bib24) 2019; 857 Bradford (10.1007/s13311-023-01360-w_bib42) 1976; 72 Kumar (10.1007/s13311-023-01360-w_bib27) 2016; 124 10.1007/s13311-023-01360-w_bib4 Mishra (10.1007/s13311-023-01360-w_bib28) 2021; 142 Pickering (10.1007/s13311-023-01360-w_bib63) 2018; 32 Elnahas (10.1007/s13311-023-01360-w_bib34) 2022; 116 Ghaleiha (10.1007/s13311-023-01360-w_bib31) 2013; 16 Lin (10.1007/s13311-023-01360-w_bib19) 2022; 23 Banerjee (10.1007/s13311-023-01360-w_bib53) 2013; 16 Coustals (10.1007/s13311-023-01360-w_bib22) 2021; 31 Serita (10.1007/s13311-023-01360-w_bib59) 2017; 7 Kang (10.1007/s13311-023-01360-w_bib26) 2015; 8 Mohamed (10.1007/s13311-023-01360-w_bib40) 2020; 885 Higashimori (10.1007/s13311-023-01360-w_bib13) 2016; 36 Grigg (10.1007/s13311-023-01360-w_bib21) 2020; 10 Chez (10.1007/s13311-023-01360-w_bib30) 2007; 22 Blankenship (10.1007/s13311-023-01360-w_bib5) 2010; 4 Essa (10.1007/s13311-023-01360-w_bib8) 2013; 23 Mookherjee (10.1007/s13311-023-01360-w_bib48) 2011; 26 Zeidan (10.1007/s13311-023-01360-w_bib3) 2022; 15 Hara (10.1007/s13311-023-01360-w_bib69) 2017; 234 Petrelli (10.1007/s13311-023-01360-w_bib1) 2016; 10 Lin (10.1007/s13311-023-01360-w_bib18) 2015; 12 Meisner (10.1007/s13311-023-01360-w_bib71) 2008; 33 Owley (10.1007/s13311-023-01360-w_bib29) 2006; 16 Struzyńska (10.1007/s13311-023-01360-w_bib47) 2004; 98 Deacon (10.1007/s13311-023-01360-w_bib39) 2006; 1 Sahu (10.1007/s13311-023-01360-w_bib50) 2017; 8 Spratt (10.1007/s13311-023-01360-w_bib60) 2015; 3 Elnahas (10.1007/s13311-023-01360-w_bib55) 2021; 108 Bristot Silvestrin (10.1007/s13311-023-01360-w_bib11) 2013; 1495 Kerr (10.1007/s13311-023-01360-w_bib37) 2013; 249 Lu (10.1007/s13311-023-01360-w_bib66) 2010; 57 Erickson (10.1007/s13311-023-01360-w_bib23) 2010; 7 Rimmele (10.1007/s13311-023-01360-w_bib51) 2016; 98 Karki (10.1007/s13311-023-01360-w_bib14) 2013; 288 John (10.1007/s13311-023-01360-w_bib44) 2003; 548 Wang (10.1007/s13311-023-01360-w_bib52) 2011; 497 Fu (10.1007/s13311-023-01360-w_bib17) 2019; 19 Aida (10.1007/s13311-023-01360-w_bib12) 2015; 40 Livak (10.1007/s13311-023-01360-w_bib43) 2001; 25 Elnaiem (10.1007/s13311-023-01360-w_bib68) 2022 Liu (10.1007/s13311-023-01360-w_bib15) 2016; 233 D'Cruz (10.1007/s13311-023-01360-w_bib46) 2016; 6 Arafat (10.1007/s13311-023-01360-w_bib61) 2019; 121 Danysz (10.1007/s13311-023-01360-w_bib25) 2012; 167 Wang (10.1007/s13311-023-01360-w_bib54) 2018; 9 Bhat (10.1007/s13311-023-01360-w_bib6) 2014; 25 Karst (10.1007/s13311-023-01360-w_bib45) 2012; 15 Sánchez-López (10.1007/s13311-023-01360-w_bib62) 2018; 14 Choi (10.1007/s13311-023-01360-w_bib36) 2019; 17 Habib (10.1007/s13311-023-01360-w_bib41) 2022; 927 Jia (10.1007/s13311-023-01360-w_bib56) 2021; 396 Takahashi (10.1007/s13311-023-01360-w_bib57) 2015; 212 Ramandi (10.1007/s13311-023-01360-w_bib10) 2021; 16 Pekny (10.1007/s13311-023-01360-w_bib9) 2014; 94 Soorya (10.1007/s13311-023-01360-w_bib32) 2021; 31 Oustad (10.1007/s13311-023-01360-w_bib65) 2020; 25 Nair (10.1007/s13311-023-01360-w_bib16) 2006; 31 Segnitz (10.1007/s13311-023-01360-w_bib70) 2009; 55 Nwaobi (10.1007/s13311-023-01360-w_bib49) 2016; 132 Amidfar (10.1007/s13311-023-01360-w_bib35) 2018; 70 Russo (10.1007/s13311-023-01360-w_bib58) 2017; 5 |
| References_xml | – volume: 23 start-page: 393 year: 2013 end-page: 400 ident: bib8 article-title: Excitotoxicity in the pathogenesis of autism publication-title: Neurotox Res – volume: 31 start-page: 4 year: 2021 end-page: 32 ident: bib22 article-title: Aripiprazole in children and adolescents publication-title: J Child Adolesc Psychopharmacol – volume: 288 start-page: 28975 year: 2013 end-page: 28986 ident: bib14 article-title: cAMP response element-binding protein (CREB) and nuclear factor κB mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes publication-title: J Biol Chem – volume: 25 start-page: 29 year: 2020 ident: bib65 article-title: Effect of donepezil and memantine on improvement of cognitive function in patients with temporal lobe epilepsy publication-title: J Res Med Sci – volume: 10 start-page: 21 year: 2016 ident: bib1 article-title: Astrocytes and microglia and their potential link with autism spectrum disorders publication-title: Front Cell Neurosci – volume: 10 start-page: 228 year: 2020 ident: bib21 article-title: Tauopathy in the young autistic brain: Novel biomarker and therapeutic target publication-title: Transl Psychiatry – volume: 116 year: 2022 ident: bib34 article-title: Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 33 start-page: 2228 year: 2008 end-page: 2236 ident: bib71 article-title: Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: A novel pharmacological action of memantine publication-title: Neuropsychopharmacology – volume: 30 start-page: 80 year: 2005 end-page: 89 ident: bib33 article-title: Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism publication-title: Neuropsychopharmacology – volume: 25 start-page: 402 year: 2001 end-page: 408 ident: bib43 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods – start-page: e2841 year: 2022 ident: bib68 article-title: Evaluation of memantine's efficacy and safety in the treatment of children with autism spectrum disorder: A systematic review and meta-analysis publication-title: Hum Psychopharmacol – volume: 234 start-page: 3217 year: 2017 end-page: 3228 ident: bib69 article-title: Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice publication-title: Psychopharmacology – volume: 23 start-page: 12734 year: 2022 ident: bib19 article-title: Neuroprotective action of coumarin derivatives through activation of TRKB-CREB-BDNF pathway and reduction of caspase activity in neuronal cells expressing pro-aggregated tau protein publication-title: Int J Mol Sci – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: bib42 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal Biochem – volume: 121 start-page: 841 year: 2019 end-page: 851 ident: bib61 article-title: The possible neuroprotective role of grape seed extract on the histopathological changes of the cerebellar cortex of rats prenatally exposed to Valproic Acid: Animal model of autism publication-title: Acta Histochem – volume: 16 year: 2021 ident: bib10 article-title: Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy publication-title: PLoS ONE – volume: 1 start-page: 122 year: 2006 end-page: 124 ident: bib39 article-title: Digging and marble burying in mice: Simple methods for in vivo identification of biological impacts publication-title: Nat Protoc – volume: 94 start-page: 1077 year: 2014 end-page: 1098 ident: bib9 article-title: Astrocyte reactivity and reactive astrogliosis: Costs and benefits publication-title: Physiol Rev – volume: 14 start-page: 1701808 year: 2018 ident: bib62 article-title: Memantine-loaded PEGylated biodegradable nanoparticles for the treatment of glaucoma publication-title: Small – volume: 142 year: 2021 ident: bib28 article-title: Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression publication-title: Neurochem Int – volume: 23 start-page: 2125 year: 2022 ident: bib72 article-title: N-acetylcysteine and aripiprazole improve social behavior and cognition and modulate brain BDNF levels in a rat model of schizophrenia publication-title: Int J Mol Sci – volume: 32 start-page: 4 year: 2018 end-page: 13 ident: bib63 article-title: Memantine for the treatment of general neuropathic pain: A narrative review publication-title: Fundam Clin Pharmacol – volume: 5 year: 2017 ident: bib58 article-title: Decreased phosphorylated CREB and AKT in individuals with autism normalized after zinc therapy publication-title: Acad J Ped Neonatol – volume: 548 start-page: 557 year: 2003 end-page: 562 ident: bib44 article-title: Intravenously administered hypocretin-1 alters brain amino acid release: An in vivo microdialysis study in rats publication-title: J Physiol – volume: 98 start-page: 19 year: 2016 end-page: 28 ident: bib51 article-title: GLT-1: The elusive presynaptic glutamate transporter publication-title: Neurochem Int – volume: 885 year: 2020 ident: bib40 article-title: Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway publication-title: Eur J Pharmacol – volume: 7 start-page: 42528 year: 2017 ident: bib59 article-title: Constitutive activation of CREB in mice enhances temporal association learning and increases hippocampal CA1 neuronal spine density and complexity publication-title: Sci Rep – volume: 17 start-page: 1611 year: 2019 end-page: 1624 ident: bib64 article-title: Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta-analysis publication-title: Exp Ther Med – volume: 167 start-page: 324 year: 2012 end-page: 352 ident: bib25 article-title: Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine–searching for the connections publication-title: Br J Pharmacol – volume: 19 start-page: 3649 year: 2019 end-page: 3657 ident: bib17 article-title: Activation of the ERK/Creb/Bcl-2 pathway protects periodontal ligament stem cells against hydrogen peroxide-induced oxidative stress publication-title: Mol Med Rep – volume: 15 start-page: 247 year: 2012 end-page: 277 ident: bib45 article-title: Parent and family impact of autism spectrum disorders: A review and proposed model for intervention evaluation publication-title: Clin Child Fam Psychol Rev – volume: 22 start-page: 574 year: 2007 end-page: 579 ident: bib30 article-title: Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: An observation of initial clinical response and maintenance tolerability publication-title: J Child Neurol – volume: 9 start-page: 1185 year: 2018 ident: bib54 article-title: Potentiation of glutamatergic synaptic transmission onto dorsal raphe serotonergic neurons in the valproic acid model of autism publication-title: Front Pharmacol – volume: 53 start-page: 699 year: 2007 end-page: 723 ident: bib67 article-title: Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system–too little activation is bad, too much is even worse publication-title: Neuropharmacology – volume: 124 start-page: 27 year: 2016 end-page: 39 ident: bib27 article-title: Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats publication-title: Brain Res Bull – volume: 15 start-page: 778 year: 2022 end-page: 790 ident: bib3 article-title: Global prevalence of autism: A systematic review update publication-title: Autism Res – volume: 25 start-page: 841 year: 2014 end-page: 850 ident: bib6 article-title: Autism: Cause factors, early diagnosis and therapies publication-title: Rev Neurosci – volume: 36 start-page: 7079 year: 2016 end-page: 7094 ident: bib13 article-title: Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo publication-title: J Neurosci – volume: 31 start-page: 423 year: 2006 end-page: 434 ident: bib16 article-title: Cyclic AMP response element binding protein and brain-derived neurotrophic factor: Molecules that modulate our mood? publication-title: J Biosci – volume: 8 start-page: 21 year: 2017 end-page: 31 ident: bib50 article-title: Biochemical changes in the injured brain publication-title: World J Biol Chem – year: 2013 ident: bib2 article-title: Diagnostic and statistical manual of mental disorders: DSM-5 – volume: 132 start-page: 1 year: 2016 end-page: 21 ident: bib49 article-title: The role of glial-specific Kir4.1 in normal and pathological states of the CNS publication-title: Acta Neuropathol – volume: 212 start-page: 319 year: 2015 end-page: 332 ident: bib57 article-title: Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease publication-title: J Exp Med – reference: Centers for Disease Control and Prevention. Key findings: CDC releases first estimates of the number of adults living with autism spectrum disorder in the United States. Available at: – volume: 1495 start-page: 52 year: 2013 end-page: 60 ident: bib11 article-title: Animal model of autism induced by prenatal exposure to valproate: Altered glutamate metabolism in the hippocampus publication-title: Brain Res – volume: 927 year: 2022 ident: bib41 article-title: Harmine prevents 3-nitropropionic acid-induced neurotoxicity in rats via enhancing NRF2-mediated signaling: Involvement of p21 and AMPK publication-title: Eur J Pharmacol – volume: 55 start-page: 619 year: 2009 end-page: 628 ident: bib70 article-title: Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats publication-title: Neurochem Int – reference: . Accessed 31 Jan 2023. – volume: 16 start-page: 517 year: 2006 end-page: 524 ident: bib29 article-title: A prospective, open-label trial of memantine in the treatment of cognitive, behavioral, and memory dysfunction in pervasive developmental disorders publication-title: J Child Adolesc Psychopharmacol – volume: 8 start-page: 17 year: 2015 ident: bib26 article-title: Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors publication-title: Front Mol Neurosci – volume: 6 year: 2016 ident: bib46 article-title: Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders publication-title: Transl Psychiatry – volume: 83 start-page: 77 year: 2021 end-page: 88 ident: bib38 article-title: Cognitive effects of the GSK-3 inhibitor "lithium" in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy publication-title: Neurotoxicology – volume: 98 start-page: 951 year: 2004 end-page: 958 ident: bib47 article-title: Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions publication-title: J Inorg Biochem – volume: 13 start-page: 357 year: 2019 ident: bib7 article-title: Glutamate transporters in hippocampal LTD/LTP: Not just prevention of excitotoxicity publication-title: Front Cell Neurosci – volume: 26 start-page: 447 year: 2011 end-page: 455 ident: bib48 article-title: GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model publication-title: J Alzheimers Dis – volume: 12 start-page: 6807 year: 2015 end-page: 6814 ident: bib18 article-title: Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus publication-title: Mol Med Rep – volume: 497 start-page: 122 year: 2011 end-page: 127 ident: bib52 article-title: Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes publication-title: Neurosci Lett – volume: 57 start-page: 168 year: 2010 end-page: 176 ident: bib66 article-title: Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: An NMDA receptor-independent mechanism publication-title: Neurochem Int – volume: 22 start-page: 1081 year: 2005 end-page: 1089 ident: bib20 article-title: Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism publication-title: Eur J Neurosci – volume: 108 year: 2021 ident: bib55 article-title: Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 233 start-page: 405 year: 2016 end-page: 415 ident: bib15 article-title: Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression publication-title: Psychopharmacology – volume: 16 start-page: 783 year: 2013 end-page: 789 ident: bib31 article-title: Memantine as adjunctive treatment to risperidone in children with autistic disorder: A randomized, double-blind, placebo-controlled trial publication-title: Int J Neuropsychopharmacol – volume: 70 start-page: 600 year: 2018 end-page: 606 ident: bib35 article-title: Effectiveness of memantine on depression-like behavior, memory deficits and brain mRNA levels of BDNF and TrkB in rats subjected to repeated unpredictable stress publication-title: Pharmacol Rep – volume: 249 start-page: 124 year: 2013 end-page: 132 ident: bib37 article-title: Alterations in the endocannabinoid system in the rat valproic acid model of autism publication-title: Behav Brain Res – volume: 396 year: 2021 ident: bib56 article-title: Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors publication-title: Behav Brain Res – volume: 17 start-page: 400 year: 2019 end-page: 408 ident: bib36 article-title: Long-term effects of aripiprazole treatment during adolescence on cognitive function and dopamine D2 receptor expression in neurodevelopmentally normal rats publication-title: Clin Psychopharmacol Neurosci – volume: 4 start-page: 375 year: 2010 end-page: 381 ident: bib5 article-title: Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6–17 years publication-title: Ped Health – volume: 40 start-page: 1569 year: 2015 end-page: 1579 ident: bib12 article-title: Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice publication-title: Neuropsychopharmacology – volume: 31 start-page: 475 year: 2021 end-page: 484 ident: bib32 article-title: Neurocognitive outcomes from memantine: A pilot, double-blind, placebo-controlled trial in children with autism spectrum disorder publication-title: J Child Adolesc Psychopharmacol – volume: 3 start-page: 19 year: 2015 end-page: 26 ident: bib60 article-title: Pilot Study and review: Physiological differences in BDNF, a potential biomarker in males and females with autistic disorder publication-title: Int Neuropsychiatr Dis J – volume: 857 year: 2019 ident: bib24 article-title: Multitarget-directed cotreatment with cilostazol and aripiprazole for augmented neuroprotection against oxidative stress-induced toxicity in HT22 mouse hippocampal cells publication-title: Eur J Pharmacol – volume: 7 start-page: 258 year: 2010 end-page: 263 ident: bib23 article-title: Aripiprazole in autism spectrum disorders and fragile X syndrome publication-title: Neurotherapeutics – volume: 16 start-page: 1309 year: 2013 end-page: 1318 ident: bib53 article-title: Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism publication-title: Int J Neuropsychopharmacol – volume: 25 start-page: 841 year: 2014 end-page: 850 ident: CR6 article-title: Autism: Cause factors, early diagnosis and therapies publication-title: Rev Neurosci doi: 10.1515/revneuro-2014-0056 – volume: 6 year: 2016 ident: CR46 article-title: Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders publication-title: Transl Psychiatry doi: 10.1038/tp.2016.161 – volume: 15 start-page: 778 year: 2022 end-page: 790 ident: CR3 article-title: Global prevalence of autism: A systematic review update publication-title: Autism Res doi: 10.1002/aur.2696 – volume: 31 start-page: 423 year: 2006 end-page: 434 ident: CR16 article-title: Cyclic AMP response element binding protein and brain-derived neurotrophic factor: Molecules that modulate our mood? publication-title: J Biosci doi: 10.1007/BF02704114 – volume: 17 start-page: 400 year: 2019 end-page: 408 ident: CR36 article-title: Long-term effects of aripiprazole treatment during adolescence on cognitive function and dopamine D2 receptor expression in neurodevelopmentally normal rats publication-title: Clin Psychopharmacol Neurosci doi: 10.9758/cpn.2019.17.3.400 – volume: 249 start-page: 124 year: 2013 end-page: 132 ident: CR37 article-title: Alterations in the endocannabinoid system in the rat valproic acid model of autism publication-title: Behav Brain Res doi: 10.1016/j.bbr.2013.04.043 – volume: 5 year: 2017 ident: CR58 article-title: Decreased phosphorylated CREB and AKT in individuals with autism normalized after zinc therapy publication-title: Acad J Ped Neonatol – ident: CR68 – ident: CR4 – volume: 234 start-page: 3217 year: 2017 end-page: 3228 ident: CR69 article-title: Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice publication-title: Psychopharmacology doi: 10.1007/s00213-017-4703-9 – volume: 94 start-page: 1077 year: 2014 end-page: 1098 ident: CR9 article-title: Astrocyte reactivity and reactive astrogliosis: Costs and benefits publication-title: Physiol Rev doi: 10.1152/physrev.00041.2013 – volume: 7 start-page: 42528 year: 2017 ident: CR59 article-title: Constitutive activation of CREB in mice enhances temporal association learning and increases hippocampal CA1 neuronal spine density and complexity publication-title: Sci Rep doi: 10.1038/srep42528 – volume: 121 start-page: 841 year: 2019 end-page: 851 ident: CR61 article-title: The possible neuroprotective role of grape seed extract on the histopathological changes of the cerebellar cortex of rats prenatally exposed to Valproic Acid: Animal model of autism publication-title: Acta Histochem doi: 10.1016/j.acthis.2019.08.002 – volume: 13 start-page: 357 year: 2019 ident: CR7 article-title: Glutamate transporters in hippocampal LTD/LTP: Not just prevention of excitotoxicity publication-title: Front Cell Neurosci doi: 10.3389/fncel.2019.00357 – volume: 10 start-page: 21 year: 2016 ident: CR1 article-title: Astrocytes and microglia and their potential link with autism spectrum disorders publication-title: Front Cell Neurosci doi: 10.3389/fncel.2016.00021 – volume: 15 start-page: 247 year: 2012 end-page: 277 ident: CR45 article-title: Parent and family impact of autism spectrum disorders: A review and proposed model for intervention evaluation publication-title: Clin Child Fam Psychol Rev doi: 10.1007/s10567-012-0119-6 – volume: 14 start-page: 1701808 year: 2018 ident: CR62 article-title: Memantine-loaded PEGylated biodegradable nanoparticles for the treatment of glaucoma publication-title: Small doi: 10.1002/smll.201701808 – volume: 108 year: 2021 ident: CR55 article-title: Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2020.110185 – volume: 16 start-page: 517 year: 2006 end-page: 524 ident: CR29 article-title: A prospective, open-label trial of memantine in the treatment of cognitive, behavioral, and memory dysfunction in pervasive developmental disorders publication-title: J Child Adolesc Psychopharmacol doi: 10.1089/cap.2006.16.517 – volume: 132 start-page: 1 year: 2016 end-page: 21 ident: CR49 article-title: The role of glial-specific Kir4.1 in normal and pathological states of the CNS publication-title: Acta Neuropathol doi: 10.1007/s00401-016-1553-1 – volume: 30 start-page: 80 year: 2005 end-page: 89 ident: CR33 article-title: Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300518 – volume: 124 start-page: 27 year: 2016 end-page: 39 ident: CR27 article-title: Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats publication-title: Brain Res Bull doi: 10.1016/j.brainresbull.2016.03.013 – volume: 33 start-page: 2228 year: 2008 end-page: 2236 ident: CR71 article-title: Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: A novel pharmacological action of memantine publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301615 – volume: 16 start-page: 1309 year: 2013 end-page: 1318 ident: CR53 article-title: Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism publication-title: Int J Neuropsychopharmacol doi: 10.1017/S1461145712001216 – volume: 36 start-page: 7079 year: 2016 end-page: 7094 ident: CR13 article-title: Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1069-16.2016 – volume: 212 start-page: 319 year: 2015 end-page: 332 ident: CR57 article-title: Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease publication-title: J Exp Med doi: 10.1084/jem.20140413 – volume: 9 start-page: 1185 year: 2018 ident: CR54 article-title: Potentiation of glutamatergic synaptic transmission onto dorsal raphe serotonergic neurons in the valproic acid model of autism publication-title: Front Pharmacol doi: 10.3389/fphar.2018.01185 – volume: 12 start-page: 6807 year: 2015 end-page: 6814 ident: CR18 article-title: Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus publication-title: Mol Med Rep doi: 10.3892/mmr.2015.4321 – volume: 8 start-page: 21 year: 2017 end-page: 31 ident: CR50 article-title: Biochemical changes in the injured brain publication-title: World J Biol Chem doi: 10.4331/wjbc.v8.i1.21 – volume: 25 start-page: 402 year: 2001 end-page: 408 ident: CR43 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 288 start-page: 28975 year: 2013 end-page: 28986 ident: CR14 article-title: cAMP response element-binding protein (CREB) and nuclear factor κB mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes publication-title: J Biol Chem doi: 10.1074/jbc.M113.483826 – volume: 31 start-page: 475 year: 2021 end-page: 484 ident: CR32 article-title: Neurocognitive outcomes from memantine: A pilot, double-blind, placebo-controlled trial in children with autism spectrum disorder publication-title: J Child Adolesc Psychopharmacol doi: 10.1089/cap.2021.0010 – volume: 10 start-page: 228 year: 2020 ident: CR21 article-title: Tauopathy in the young autistic brain: Novel biomarker and therapeutic target publication-title: Transl Psychiatry doi: 10.1038/s41398-020-00904-4 – volume: 83 start-page: 77 year: 2021 end-page: 88 ident: CR38 article-title: Cognitive effects of the GSK-3 inhibitor "lithium" in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy publication-title: Neurotoxicology doi: 10.1016/j.neuro.2020.12.016 – volume: 16 year: 2021 ident: CR10 article-title: Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy publication-title: PLoS ONE doi: 10.1371/journal.pone.0246068 – volume: 7 start-page: 258 year: 2010 end-page: 263 ident: CR23 article-title: Aripiprazole in autism spectrum disorders and fragile X syndrome publication-title: Neurotherapeutics doi: 10.1016/j.nurt.2010.04.001 – volume: 23 start-page: 393 year: 2013 end-page: 400 ident: CR8 article-title: Excitotoxicity in the pathogenesis of autism publication-title: Neurotox Res doi: 10.1007/s12640-012-9354-3 – volume: 31 start-page: 4 year: 2021 end-page: 32 ident: CR22 article-title: Aripiprazole in children and adolescents publication-title: J Child Adolesc Psychopharmacol doi: 10.1089/cap.2020.0014 – volume: 1 start-page: 122 year: 2006 end-page: 124 ident: CR39 article-title: Digging and marble burying in mice: Simple methods for in vivo identification of biological impacts publication-title: Nat Protoc doi: 10.1038/nprot.2006.20 – volume: 17 start-page: 1611 year: 2019 end-page: 1624 ident: CR64 article-title: Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta-analysis publication-title: Exp Ther Med – volume: 22 start-page: 574 year: 2007 end-page: 579 ident: CR30 article-title: Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: An observation of initial clinical response and maintenance tolerability publication-title: J Child Neurol doi: 10.1177/0883073807302611 – volume: 98 start-page: 19 year: 2016 end-page: 28 ident: CR51 article-title: GLT-1: The elusive presynaptic glutamate transporter publication-title: Neurochem Int doi: 10.1016/j.neuint.2016.04.010 – volume: 70 start-page: 600 year: 2018 end-page: 606 ident: CR35 article-title: Effectiveness of memantine on depression-like behavior, memory deficits and brain mRNA levels of BDNF and TrkB in rats subjected to repeated unpredictable stress publication-title: Pharmacol Rep doi: 10.1016/j.pharep.2017.12.007 – ident: CR2 – volume: 857 year: 2019 ident: CR24 article-title: Multitarget-directed cotreatment with cilostazol and aripiprazole for augmented neuroprotection against oxidative stress-induced toxicity in HT22 mouse hippocampal cells publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2019.172454 – volume: 3 start-page: 19 year: 2015 end-page: 26 ident: CR60 article-title: Pilot Study and review: Physiological differences in BDNF, a potential biomarker in males and females with autistic disorder publication-title: Int Neuropsychiatr Dis J doi: 10.9734/INDJ/2015/12118 – volume: 23 start-page: 2125 year: 2022 ident: CR72 article-title: N-acetylcysteine and aripiprazole improve social behavior and cognition and modulate brain BDNF levels in a rat model of schizophrenia publication-title: Int J Mol Sci doi: 10.3390/ijms23042125 – volume: 19 start-page: 3649 year: 2019 end-page: 3657 ident: CR17 article-title: Activation of the ERK/Creb/Bcl-2 pathway protects periodontal ligament stem cells against hydrogen peroxide-induced oxidative stress publication-title: Mol Med Rep – volume: 53 start-page: 699 year: 2007 end-page: 723 ident: CR67 article-title: Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system–too little activation is bad, too much is even worse publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2007.07.013 – volume: 233 start-page: 405 year: 2016 end-page: 415 ident: CR15 article-title: Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression publication-title: Psychopharmacology doi: 10.1007/s00213-015-4128-2 – volume: 16 start-page: 783 year: 2013 end-page: 789 ident: CR31 article-title: Memantine as adjunctive treatment to risperidone in children with autistic disorder: A randomized, double-blind, placebo-controlled trial publication-title: Int J Neuropsychopharmacol doi: 10.1017/S1461145712000880 – volume: 927 year: 2022 ident: CR41 article-title: Harmine prevents 3-nitropropionic acid-induced neurotoxicity in rats via enhancing NRF2-mediated signaling: Involvement of p21 and AMPK publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2022.175046 – volume: 1495 start-page: 52 year: 2013 end-page: 60 ident: CR11 article-title: Animal model of autism induced by prenatal exposure to valproate: Altered glutamate metabolism in the hippocampus publication-title: Brain Res doi: 10.1016/j.brainres.2012.11.048 – volume: 23 start-page: 12734 year: 2022 ident: CR19 article-title: Neuroprotective action of coumarin derivatives through activation of TRKB-CREB-BDNF pathway and reduction of caspase activity in neuronal cells expressing pro-aggregated tau protein publication-title: Int J Mol Sci doi: 10.3390/ijms232112734 – volume: 8 start-page: 17 year: 2015 ident: CR26 article-title: Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2015.00017 – volume: 25 start-page: 29 year: 2020 ident: CR65 article-title: Effect of donepezil and memantine on improvement of cognitive function in patients with temporal lobe epilepsy publication-title: J Res Med Sci – volume: 40 start-page: 1569 year: 2015 end-page: 1579 ident: CR12 article-title: Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice publication-title: Neuropsychopharmacology doi: 10.1038/npp.2015.26 – volume: 55 start-page: 619 year: 2009 end-page: 628 ident: CR70 article-title: Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats publication-title: Neurochem Int doi: 10.1016/j.neuint.2009.06.003 – volume: 57 start-page: 168 year: 2010 end-page: 176 ident: CR66 article-title: Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: An NMDA receptor-independent mechanism publication-title: Neurochem Int doi: 10.1016/j.neuint.2010.05.010 – volume: 26 start-page: 447 year: 2011 end-page: 455 ident: CR48 article-title: GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model publication-title: J Alzheimers Dis doi: 10.3233/JAD-2011-110503 – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: CR42 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal Biochem doi: 10.1016/0003-2697(76)90527-3 – volume: 32 start-page: 4 year: 2018 end-page: 13 ident: CR63 article-title: Memantine for the treatment of general neuropathic pain: A narrative review publication-title: Fundam Clin Pharmacol doi: 10.1111/fcp.12316 – volume: 98 start-page: 951 year: 2004 end-page: 958 ident: CR47 article-title: Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions publication-title: J Inorg Biochem doi: 10.1016/j.jinorgbio.2004.02.010 – volume: 4 start-page: 375 year: 2010 end-page: 381 ident: CR5 article-title: Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6–17 years publication-title: Ped Health doi: 10.2217/phe.10.45 – volume: 167 start-page: 324 year: 2012 end-page: 352 ident: CR25 article-title: Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine–searching for the connections publication-title: Br J Pharmacol doi: 10.1111/j.1476-5381.2012.02057.x – volume: 396 year: 2021 ident: CR56 article-title: Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors publication-title: Behav Brain Res doi: 10.1016/j.bbr.2020.112906 – volume: 22 start-page: 1081 year: 2005 end-page: 1089 ident: CR20 article-title: Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2005.04290.x – volume: 142 year: 2021 ident: CR28 article-title: Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression publication-title: Neurochem Int doi: 10.1016/j.neuint.2020.104932 – volume: 116 year: 2022 ident: CR34 article-title: Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2022.110522 – volume: 548 start-page: 557 year: 2003 end-page: 562 ident: CR44 article-title: Intravenously administered hypocretin-1 alters brain amino acid release: An in vivo microdialysis study in rats publication-title: J Physiol doi: 10.1113/jphysiol.2002.038729 – volume: 885 year: 2020 ident: CR40 article-title: Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2020.173411 – volume: 497 start-page: 122 year: 2011 end-page: 127 ident: CR52 article-title: Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes publication-title: Neurosci Lett doi: 10.1016/j.neulet.2011.04.044 – volume: 31 start-page: 4 year: 2021 ident: 10.1007/s13311-023-01360-w_bib22 article-title: Aripiprazole in children and adolescents publication-title: J Child Adolesc Psychopharmacol doi: 10.1089/cap.2020.0014 – volume: 16 start-page: 517 year: 2006 ident: 10.1007/s13311-023-01360-w_bib29 article-title: A prospective, open-label trial of memantine in the treatment of cognitive, behavioral, and memory dysfunction in pervasive developmental disorders publication-title: J Child Adolesc Psychopharmacol doi: 10.1089/cap.2006.16.517 – volume: 26 start-page: 447 year: 2011 ident: 10.1007/s13311-023-01360-w_bib48 article-title: GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model publication-title: J Alzheimers Dis doi: 10.3233/JAD-2011-110503 – volume: 497 start-page: 122 year: 2011 ident: 10.1007/s13311-023-01360-w_bib52 article-title: Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes publication-title: Neurosci Lett doi: 10.1016/j.neulet.2011.04.044 – volume: 1 start-page: 122 year: 2006 ident: 10.1007/s13311-023-01360-w_bib39 article-title: Digging and marble burying in mice: Simple methods for in vivo identification of biological impacts publication-title: Nat Protoc doi: 10.1038/nprot.2006.20 – volume: 25 start-page: 841 year: 2014 ident: 10.1007/s13311-023-01360-w_bib6 article-title: Autism: Cause factors, early diagnosis and therapies publication-title: Rev Neurosci doi: 10.1515/revneuro-2014-0056 – volume: 72 start-page: 248 year: 1976 ident: 10.1007/s13311-023-01360-w_bib42 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal Biochem doi: 10.1016/0003-2697(76)90527-3 – ident: 10.1007/s13311-023-01360-w_bib4 – volume: 6 year: 2016 ident: 10.1007/s13311-023-01360-w_bib46 article-title: Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders publication-title: Transl Psychiatry doi: 10.1038/tp.2016.161 – volume: 121 start-page: 841 year: 2019 ident: 10.1007/s13311-023-01360-w_bib61 article-title: The possible neuroprotective role of grape seed extract on the histopathological changes of the cerebellar cortex of rats prenatally exposed to Valproic Acid: Animal model of autism publication-title: Acta Histochem doi: 10.1016/j.acthis.2019.08.002 – volume: 33 start-page: 2228 year: 2008 ident: 10.1007/s13311-023-01360-w_bib71 article-title: Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: A novel pharmacological action of memantine publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301615 – volume: 23 start-page: 393 year: 2013 ident: 10.1007/s13311-023-01360-w_bib8 article-title: Excitotoxicity in the pathogenesis of autism publication-title: Neurotox Res doi: 10.1007/s12640-012-9354-3 – volume: 14 start-page: 1701808 year: 2018 ident: 10.1007/s13311-023-01360-w_bib62 article-title: Memantine-loaded PEGylated biodegradable nanoparticles for the treatment of glaucoma publication-title: Small doi: 10.1002/smll.201701808 – volume: 234 start-page: 3217 year: 2017 ident: 10.1007/s13311-023-01360-w_bib69 article-title: Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice publication-title: Psychopharmacology doi: 10.1007/s00213-017-4703-9 – volume: 116 year: 2022 ident: 10.1007/s13311-023-01360-w_bib34 article-title: Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2022.110522 – volume: 17 start-page: 400 year: 2019 ident: 10.1007/s13311-023-01360-w_bib36 article-title: Long-term effects of aripiprazole treatment during adolescence on cognitive function and dopamine D2 receptor expression in neurodevelopmentally normal rats publication-title: Clin Psychopharmacol Neurosci doi: 10.9758/cpn.2019.17.3.400 – volume: 25 start-page: 402 year: 2001 ident: 10.1007/s13311-023-01360-w_bib43 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 23 start-page: 2125 year: 2022 ident: 10.1007/s13311-023-01360-w_bib72 article-title: N-acetylcysteine and aripiprazole improve social behavior and cognition and modulate brain BDNF levels in a rat model of schizophrenia publication-title: Int J Mol Sci doi: 10.3390/ijms23042125 – volume: 233 start-page: 405 year: 2016 ident: 10.1007/s13311-023-01360-w_bib15 article-title: Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression publication-title: Psychopharmacology doi: 10.1007/s00213-015-4128-2 – volume: 17 start-page: 1611 year: 2019 ident: 10.1007/s13311-023-01360-w_bib64 article-title: Cholinesterase inhibitors and memantine for Parkinson's disease dementia and Lewy body dementia: A meta-analysis publication-title: Exp Ther Med – volume: 3 start-page: 19 year: 2015 ident: 10.1007/s13311-023-01360-w_bib60 article-title: Pilot Study and review: Physiological differences in BDNF, a potential biomarker in males and females with autistic disorder publication-title: Int Neuropsychiatr Dis J doi: 10.9734/INDJ/2015/12118 – volume: 23 start-page: 12734 year: 2022 ident: 10.1007/s13311-023-01360-w_bib19 article-title: Neuroprotective action of coumarin derivatives through activation of TRKB-CREB-BDNF pathway and reduction of caspase activity in neuronal cells expressing pro-aggregated tau protein publication-title: Int J Mol Sci doi: 10.3390/ijms232112734 – volume: 167 start-page: 324 year: 2012 ident: 10.1007/s13311-023-01360-w_bib25 article-title: Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine–searching for the connections publication-title: Br J Pharmacol doi: 10.1111/j.1476-5381.2012.02057.x – volume: 927 year: 2022 ident: 10.1007/s13311-023-01360-w_bib41 article-title: Harmine prevents 3-nitropropionic acid-induced neurotoxicity in rats via enhancing NRF2-mediated signaling: Involvement of p21 and AMPK publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2022.175046 – volume: 31 start-page: 475 year: 2021 ident: 10.1007/s13311-023-01360-w_bib32 article-title: Neurocognitive outcomes from memantine: A pilot, double-blind, placebo-controlled trial in children with autism spectrum disorder publication-title: J Child Adolesc Psychopharmacol doi: 10.1089/cap.2021.0010 – volume: 70 start-page: 600 year: 2018 ident: 10.1007/s13311-023-01360-w_bib35 article-title: Effectiveness of memantine on depression-like behavior, memory deficits and brain mRNA levels of BDNF and TrkB in rats subjected to repeated unpredictable stress publication-title: Pharmacol Rep doi: 10.1016/j.pharep.2017.12.007 – volume: 36 start-page: 7079 year: 2016 ident: 10.1007/s13311-023-01360-w_bib13 article-title: Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1069-16.2016 – volume: 30 start-page: 80 year: 2005 ident: 10.1007/s13311-023-01360-w_bib33 article-title: Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300518 – volume: 1495 start-page: 52 year: 2013 ident: 10.1007/s13311-023-01360-w_bib11 article-title: Animal model of autism induced by prenatal exposure to valproate: Altered glutamate metabolism in the hippocampus publication-title: Brain Res doi: 10.1016/j.brainres.2012.11.048 – volume: 16 year: 2021 ident: 10.1007/s13311-023-01360-w_bib10 article-title: Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy publication-title: PLoS ONE doi: 10.1371/journal.pone.0246068 – volume: 108 year: 2021 ident: 10.1007/s13311-023-01360-w_bib55 article-title: Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2020.110185 – year: 2013 ident: 10.1007/s13311-023-01360-w_bib2 – volume: 7 start-page: 258 year: 2010 ident: 10.1007/s13311-023-01360-w_bib23 article-title: Aripiprazole in autism spectrum disorders and fragile X syndrome publication-title: Neurotherapeutics doi: 10.1016/j.nurt.2010.04.001 – volume: 885 year: 2020 ident: 10.1007/s13311-023-01360-w_bib40 article-title: Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2020.173411 – volume: 212 start-page: 319 year: 2015 ident: 10.1007/s13311-023-01360-w_bib57 article-title: Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease publication-title: J Exp Med doi: 10.1084/jem.20140413 – volume: 7 start-page: 42528 year: 2017 ident: 10.1007/s13311-023-01360-w_bib59 article-title: Constitutive activation of CREB in mice enhances temporal association learning and increases hippocampal CA1 neuronal spine density and complexity publication-title: Sci Rep doi: 10.1038/srep42528 – volume: 8 start-page: 17 year: 2015 ident: 10.1007/s13311-023-01360-w_bib26 article-title: Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2015.00017 – volume: 22 start-page: 574 year: 2007 ident: 10.1007/s13311-023-01360-w_bib30 article-title: Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: An observation of initial clinical response and maintenance tolerability publication-title: J Child Neurol doi: 10.1177/0883073807302611 – volume: 19 start-page: 3649 year: 2019 ident: 10.1007/s13311-023-01360-w_bib17 article-title: Activation of the ERK/Creb/Bcl-2 pathway protects periodontal ligament stem cells against hydrogen peroxide-induced oxidative stress publication-title: Mol Med Rep – volume: 5 year: 2017 ident: 10.1007/s13311-023-01360-w_bib58 article-title: Decreased phosphorylated CREB and AKT in individuals with autism normalized after zinc therapy publication-title: Acad J Ped Neonatol – volume: 22 start-page: 1081 year: 2005 ident: 10.1007/s13311-023-01360-w_bib20 article-title: Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2005.04290.x – volume: 396 year: 2021 ident: 10.1007/s13311-023-01360-w_bib56 article-title: Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors publication-title: Behav Brain Res doi: 10.1016/j.bbr.2020.112906 – volume: 55 start-page: 619 year: 2009 ident: 10.1007/s13311-023-01360-w_bib70 article-title: Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats publication-title: Neurochem Int doi: 10.1016/j.neuint.2009.06.003 – volume: 4 start-page: 375 year: 2010 ident: 10.1007/s13311-023-01360-w_bib5 article-title: Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6–17 years publication-title: Ped Health doi: 10.2217/phe.10.45 – volume: 124 start-page: 27 year: 2016 ident: 10.1007/s13311-023-01360-w_bib27 article-title: Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats publication-title: Brain Res Bull doi: 10.1016/j.brainresbull.2016.03.013 – volume: 32 start-page: 4 year: 2018 ident: 10.1007/s13311-023-01360-w_bib63 article-title: Memantine for the treatment of general neuropathic pain: A narrative review publication-title: Fundam Clin Pharmacol doi: 10.1111/fcp.12316 – volume: 98 start-page: 951 year: 2004 ident: 10.1007/s13311-023-01360-w_bib47 article-title: Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions publication-title: J Inorg Biochem doi: 10.1016/j.jinorgbio.2004.02.010 – volume: 857 year: 2019 ident: 10.1007/s13311-023-01360-w_bib24 article-title: Multitarget-directed cotreatment with cilostazol and aripiprazole for augmented neuroprotection against oxidative stress-induced toxicity in HT22 mouse hippocampal cells publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2019.172454 – volume: 25 start-page: 29 year: 2020 ident: 10.1007/s13311-023-01360-w_bib65 article-title: Effect of donepezil and memantine on improvement of cognitive function in patients with temporal lobe epilepsy publication-title: J Res Med Sci doi: 10.4103/jrms.JRMS_209_19 – volume: 548 start-page: 557 year: 2003 ident: 10.1007/s13311-023-01360-w_bib44 article-title: Intravenously administered hypocretin-1 alters brain amino acid release: An in vivo microdialysis study in rats publication-title: J Physiol doi: 10.1113/jphysiol.2002.038729 – volume: 12 start-page: 6807 year: 2015 ident: 10.1007/s13311-023-01360-w_bib18 article-title: Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus publication-title: Mol Med Rep doi: 10.3892/mmr.2015.4321 – volume: 132 start-page: 1 year: 2016 ident: 10.1007/s13311-023-01360-w_bib49 article-title: The role of glial-specific Kir4.1 in normal and pathological states of the CNS publication-title: Acta Neuropathol doi: 10.1007/s00401-016-1553-1 – start-page: e2841 year: 2022 ident: 10.1007/s13311-023-01360-w_bib68 article-title: Evaluation of memantine's efficacy and safety in the treatment of children with autism spectrum disorder: A systematic review and meta-analysis publication-title: Hum Psychopharmacol doi: 10.1002/hup.2841 – volume: 83 start-page: 77 year: 2021 ident: 10.1007/s13311-023-01360-w_bib38 article-title: Cognitive effects of the GSK-3 inhibitor "lithium" in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy publication-title: Neurotoxicology doi: 10.1016/j.neuro.2020.12.016 – volume: 10 start-page: 21 year: 2016 ident: 10.1007/s13311-023-01360-w_bib1 article-title: Astrocytes and microglia and their potential link with autism spectrum disorders publication-title: Front Cell Neurosci doi: 10.3389/fncel.2016.00021 – volume: 249 start-page: 124 year: 2013 ident: 10.1007/s13311-023-01360-w_bib37 article-title: Alterations in the endocannabinoid system in the rat valproic acid model of autism publication-title: Behav Brain Res doi: 10.1016/j.bbr.2013.04.043 – volume: 16 start-page: 1309 year: 2013 ident: 10.1007/s13311-023-01360-w_bib53 article-title: Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism publication-title: Int J Neuropsychopharmacol doi: 10.1017/S1461145712001216 – volume: 9 start-page: 1185 year: 2018 ident: 10.1007/s13311-023-01360-w_bib54 article-title: Potentiation of glutamatergic synaptic transmission onto dorsal raphe serotonergic neurons in the valproic acid model of autism publication-title: Front Pharmacol doi: 10.3389/fphar.2018.01185 – volume: 142 year: 2021 ident: 10.1007/s13311-023-01360-w_bib28 article-title: Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression publication-title: Neurochem Int doi: 10.1016/j.neuint.2020.104932 – volume: 16 start-page: 783 year: 2013 ident: 10.1007/s13311-023-01360-w_bib31 article-title: Memantine as adjunctive treatment to risperidone in children with autistic disorder: A randomized, double-blind, placebo-controlled trial publication-title: Int J Neuropsychopharmacol doi: 10.1017/S1461145712000880 – volume: 94 start-page: 1077 year: 2014 ident: 10.1007/s13311-023-01360-w_bib9 article-title: Astrocyte reactivity and reactive astrogliosis: Costs and benefits publication-title: Physiol Rev doi: 10.1152/physrev.00041.2013 – volume: 57 start-page: 168 year: 2010 ident: 10.1007/s13311-023-01360-w_bib66 article-title: Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: An NMDA receptor-independent mechanism publication-title: Neurochem Int doi: 10.1016/j.neuint.2010.05.010 – volume: 15 start-page: 778 year: 2022 ident: 10.1007/s13311-023-01360-w_bib3 article-title: Global prevalence of autism: A systematic review update publication-title: Autism Res doi: 10.1002/aur.2696 – volume: 53 start-page: 699 year: 2007 ident: 10.1007/s13311-023-01360-w_bib67 article-title: Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system–too little activation is bad, too much is even worse publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2007.07.013 – volume: 10 start-page: 228 year: 2020 ident: 10.1007/s13311-023-01360-w_bib21 article-title: Tauopathy in the young autistic brain: Novel biomarker and therapeutic target publication-title: Transl Psychiatry doi: 10.1038/s41398-020-00904-4 – volume: 31 start-page: 423 year: 2006 ident: 10.1007/s13311-023-01360-w_bib16 article-title: Cyclic AMP response element binding protein and brain-derived neurotrophic factor: Molecules that modulate our mood? publication-title: J Biosci doi: 10.1007/BF02704114 – volume: 98 start-page: 19 year: 2016 ident: 10.1007/s13311-023-01360-w_bib51 article-title: GLT-1: The elusive presynaptic glutamate transporter publication-title: Neurochem Int doi: 10.1016/j.neuint.2016.04.010 – volume: 40 start-page: 1569 year: 2015 ident: 10.1007/s13311-023-01360-w_bib12 article-title: Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice publication-title: Neuropsychopharmacology doi: 10.1038/npp.2015.26 – volume: 15 start-page: 247 year: 2012 ident: 10.1007/s13311-023-01360-w_bib45 article-title: Parent and family impact of autism spectrum disorders: A review and proposed model for intervention evaluation publication-title: Clin Child Fam Psychol Rev doi: 10.1007/s10567-012-0119-6 – volume: 8 start-page: 21 year: 2017 ident: 10.1007/s13311-023-01360-w_bib50 article-title: Biochemical changes in the injured brain publication-title: World J Biol Chem doi: 10.4331/wjbc.v8.i1.21 – volume: 288 start-page: 28975 year: 2013 ident: 10.1007/s13311-023-01360-w_bib14 article-title: cAMP response element-binding protein (CREB) and nuclear factor κB mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes publication-title: J Biol Chem doi: 10.1074/jbc.M113.483826 – volume: 13 start-page: 357 year: 2019 ident: 10.1007/s13311-023-01360-w_bib7 article-title: Glutamate transporters in hippocampal LTD/LTP: Not just prevention of excitotoxicity publication-title: Front Cell Neurosci doi: 10.3389/fncel.2019.00357 |
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| Snippet | Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of aberrant... Summary Significant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of... SummarySignificant efforts are increasingly directed towards identifying novel therapeutic targets for autism spectrum disorder (ASD) with a rising role of... |
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| SubjectTerms | Animal models Animals Apoptosis Aripiprazole Aripiprazole - adverse effects Astrocyte Autism Autism spectrum disorder Autism Spectrum Disorder - chemically induced Autism Spectrum Disorder - drug therapy Autistic Disorder - chemically induced Autistic Disorder - drug therapy Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cognitive ability Cognitive dysfunction Cognitive Dysfunction - chemically induced Cognitive Dysfunction - complications Cognitive Dysfunction - drug therapy Cyclic AMP response element-binding protein Disease Models, Animal Female gamma-Aminobutyric Acid - pharmacology Gene expression Glutamate Glutamatergic transmission Glutamates - adverse effects Glutamic acid transporter Hippocampus Homeostasis Male Maze learning Memantine Memantine - adverse effects Neurobiology Neurofibrillary tangles Neurology Neurosciences Neurosurgery Original Original Article Pregnancy Protein structure Proteins Rats Rats, Wistar Sodium valproate Spatial discrimination learning Stereotyped behavior Therapeutic targets Valproic Acid γ-Aminobutyric acid |
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| Title | Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis |
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