Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression

• Published in: Cancer cell Vol. 41; no. 12; pp. 2019 - 2037.e8
• Main Authors: Huang, Kie Kyon, Ma, Haoran, Chong, Roxanne Hui Heng, Uchihara, Tomoyuki, Lian, Benedict Shi Xiang, Zhu, Feng, Sheng, Taotao, Srivastava, Supriya, Tay, Su Ting, Sundar, Raghav, Tan, Angie Lay Keng, Ong, Xuewen, Lee, Minghui, Ho, Shamaine Wei Ting, Lesluyes, Tom, Ashktorab, Hassan, Smoot, Duane, Van Loo, Peter, Chua, Joy Shijia, Ramnarayanan, Kalpana, Lau, Louis Ho Shing, Gotoda, Takuji, Kim, Hyun Soo, Ang, Tiing Leong, Khor, Christopher, Lee, Jonathan Wei Jie, Tsao, Stephen Kin Kwok, Yang, Wei Lyn, Teh, Ming, Chung, Hyunsoo, So, Jimmy Bok Yan, Yeoh, Khay Guan, Tan, Patrick
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.12.2023; Cell Press
• Subjects: cancer screening; cell-of-origin; gastric cancer; Gastric Mucosa - pathology; Genomics; Humans; intestinal metaplasia; Metaplasia - genetics; pre-cancer; Precancerous Conditions - genetics; Prospective Studies; single-cell sequencing; spatial transcriptomics; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; targeted DNA sequencing; transcriptome sequencing; targeted DNA sequencing; single-cell sequencing; cancer screening; gastric cancer; transcriptome sequencing; intestinal metaplasia; spatial transcriptomics; cell-of-origin; pre-cancer

Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 subjects from a prospective 10-year study, we identify 26 IM driver genes in diverse pathways including chromatin r...