Regulation of Constitutive Neutrophil Apoptosis Due to House Dust Mite Allergen in Normal and Allergic Rhinitis Subjects

• Published in: PloS one Vol. 9; no. 9; p. e105814
• Main Authors: Kim, Eun Hye, Lee, Ji-Sook, Lee, Na Rae, Baek, Seung Yeop, Kim, Eun Jeong, Lee, Soo Jin, Kim, In Sik
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.09.2014; Public Library of Science (PLoS)
• Subjects: Adolescent; Allergens; Allergens - immunology; Allergic diseases; Allergic rhinitis; Allergies; Animals; Antigens, Dermatophagoides - immunology; Apoptosis; Apoptosis - immunology; Asthma; Biology and Life Sciences; Child; Cysteine proteinase; Cytokines - metabolism; Dust; Extracellular signal-regulated kinase; Female; Gene expression; Granulocyte colony-stimulating factor; Granulocyte-macrophage colony-stimulating factor; Histamine; House dust; Humans; Immunity; Immunoassay; Immunoglobulin E; Immunoglobulin E - immunology; Immunoglobulins; Innate immunity; Interleukin 6; Interleukin 8; Laboratories; Leukocytes (neutrophilic); Male; Medicine; Mites; Monocyte chemoattractant protein 1; Neutrophils; Neutrophils - immunology; Neutrophils - metabolism; NF-κB protein; Nose; Pediatrics; Protease; Protease inhibitors; Protein kinase C; Proteinase inhibitors; Pyroglyphidae; Review boards; Rhinitis; Rhinitis, Allergic - immunology; Rhinitis, Allergic - metabolism; Science; Serine; Serine proteinase; TLR4 protein; Toll-like receptors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Young Adult

House dust mite (HDM) is a primary allergen in allergic rhinitis (AR) and asthma. Neutrophil apoptosis is associated with allergic diseases and innate immunity to infection. The present study examined how HDM affects constitutive neutrophil apoptosis in normal and AR subjects. Total IgE increased in...