Comparison of 24-h urinary aldosterone level and random urinary aldosterone-to-creatinine ratio in the diagnosis of primary aldosteronism

• Published in: PloS one Vol. 8; no. 6; p. e67417
• Main Authors: Wu, Che-Hsiung, Yang, Ya-Wen, Hu, Ya-Hui, Tsai, Yao-Chou, Kuo, Ko-Lin, Lin, Yen-Hung, Hung, Szu-Chun, Wu, Vin-Cent, Wu, Kwan-Dun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.06.2013; Public Library of Science (PLoS)
• Subjects: Adenoma; Adenoma - complications; Adenoma - urine; Adrenal Gland Neoplasms - complications; Adrenal Gland Neoplasms - urine; Adrenal glands; Adult; Aldosterone; Aldosterone - urine; Biology; Bladder; Buddhism; Chemistry; Creatinine; Creatinine - urine; Diagnosis; Diagnostic software; Diagnostic systems; Endocrine disorders; Essential Hypertension; Female; Historical account; Hospitals; Humans; Hyperaldosteronism - diagnosis; Hyperaldosteronism - etiology; Hyperaldosteronism - urine; Hypertension; Hypertension - urine; Hypokalemia; Internal medicine; Kinases; Male; Medical diagnosis; Medical imaging; Medicine; Metabolism; Middle Aged; Nephrology; Patients; Plasma; Potassium; Prospective Studies; Restoration; ROC Curve; Salt loading; Salts; Sodium; Studies; Surgery; Tomography; Tumors; Urinary bladder; Urine; Taiwan

Historically, urinary aldosterone level measurement was a commonly employed confirmatory test to detect primary aldosteronism (PA). However, 24-h urine collection is inconvenient and cumbersome. We hypothesized that random urinary aldosterone measurements with correction for creatinine concentration...