A comparative atlas of single-cell chromatin accessibility in the human brain

• Published in: Science (American Association for the Advancement of Science) Vol. 382; no. 6667; p. eadf7044
• Main Authors: Li, Yang Eric, Preissl, Sebastian, Miller, Michael, Johnson, Nicholas D., Wang, Zihan, Jiao, Henry, Zhu, Chenxu, Wang, Zhaoning, Xie, Yang, Poirion, Olivier, Kern, Colin, Pinto-Duarte, Antonio, Tian, Wei, Siletti, Kimberly, Emerson, Nora, Osteen, Julia, Lucero, Jacinta, Lin, Lin, Yang, Qian, Zhu, Quan, Zemke, Nathan, Espinoza, Sarah, Yanny, Anna Marie, Nyhus, Julie, Dee, Nick, Casper, Tamara, Shapovalova, Nadiya, Hirschstein, Daniel, Hodge, Rebecca D., Linnarsson, Sten, Bakken, Trygve, Levi, Boaz, Keene, C. Dirk, Shang, Jingbo, Lein, Ed, Wang, Allen, Behrens, M. Margarita, Ecker, Joseph R., Ren, Bing
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 13.10.2023
• Subjects: Accessibility; Animals; Annotations; Atlases as Topic; Brain; Brain - cytology; Brain - metabolism; Chromatin - metabolism; Chromatin remodeling; Coding; Conserved sequence; Disorders; DNA - metabolism; Etiology; Gene expression; Gene mapping; Gene regulation; Genomes; Health risks; Heterogeneity; Humans; Machine learning; Mental disorders; Meta Analysis; Mice; Neurons - metabolism; Non-coding RNA; Nucleotide sequence; Proteins; Regulatory sequences; Regulatory Sequences, Nucleic Acid - genetics; Risk; Sequences; Single-Cell Analysis

Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the regulatory programs governing cell identity and function remain unclear. Using a single-nucleus assay for transposase-accessible chromatin using sequencing (...