Causal association of breast cancer with immune cells: new evidence from bi-directional Mendelian randomization using GWAS summary statistics

• Published in: BMC cancer Vol. 25; no. 1; pp. 609 - 9
• Main Authors: Wu, Zhixuan, Zhang, Rongrong, Wu, Xue, Meng, Xinyu, Wu, Haodong, Wang, Xiaowu, Zheng, Danni, Shen, Yanyan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.04.2025; BioMed Central; BMC
• Subjects: Analysis; B cells; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Cancer; Cancer therapies; Care and treatment; Causal inference; Cells; Confounding (Statistics); Datasets; Development and progression; Female; Fibroblasts; Genetic aspects; Genetic Predisposition to Disease; Genome wide association study; Genome-wide association studies; Genomes; Genomics; Health aspects; Humans; Immune cells; Lymphocytes; Medical prognosis; Mendelian randomization; Mendelian Randomization Analysis; Oncology, Experimental; Phenotypes; Pleiotropy; Polymorphism, Single Nucleotide; Population studies; Prognosis; Software; Statistics; Tumor microenvironment; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; China; Causal inference; Breast cancer; Mendelian randomization; Genome wide association study; Immune cells

The tumor microenvironment of breast cancer encompasses a broad spectrum of immune cell populations. These cell populations are biologically/clinically relevant to varying degrees. The causal relationship between these immune cells and breast cancer remains uncertain despite their relevance. Bi-dire...