Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation

• Published in: PloS one Vol. 8; no. 3; p. e58979
• Main Authors: Sotnikov, Ilya, Veremeyko, Tatyana, Starossom, Sarah C, Barteneva, Natalia, Weiner, Howard L, Ponomarev, Eugene D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.03.2013; Public Library of Science (PLoS)
• Subjects: Anaphylaxis; Anaphylaxis - immunology; Anaphylaxis - metabolism; Animals; Astrocytes - immunology; Astrocytes - metabolism; Biological Transport; Biology; Blood platelets; Blood Platelets - immunology; Blood Platelets - metabolism; Blood-Brain Barrier - metabolism; Brain; Brain - immunology; Brain - metabolism; Brain damage; Cardiac arrhythmia; Cascades; Cell Degranulation; Central nervous system; Central Nervous System - immunology; Central Nervous System - metabolism; Cerebrovascular Disorders - immunology; Cerebrovascular Disorders - metabolism; Degranulation; Disease; Disease Models, Animal; Dyspnea; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - metabolism; Gangliosides; Gangliosides - immunology; Glycolipids - immunology; Glycolipids - metabolism; Glycosphingolipids; Hospitals; Immune response; Immune system; Inflammation; Inflammation - immunology; Inflammation - metabolism; Lipid rafts; Lipids; Mathematics; Medical schools; Medicine; Membrane Microdomains - chemistry; Membrane Microdomains - immunology; Membrane Microdomains - metabolism; Mice; Neurodegenerative diseases; Neurological diseases; Neurons - immunology; Neurons - metabolism; P-selectin; Parenchyma; Pathogenesis; Phenotypes; Platelets; Protein Binding; Rafts; Receptors; Receptors, Cell Surface - metabolism; Rigid structures; Womens health; United States > US; Massachusetts

Platelets respond to vascular damage and contribute to inflammation, but their role in the neurodegenerative diseases is unknown. We found that the systemic administration of brain lipid rafts induced a massive platelet activation and degranulation resulting in a life-threatening anaphylactic-like r...