Dysregulated Renin–Angiotensin–Aldosterone System Contributes to Pulmonary Arterial Hypertension - de Man, Frances S.; Tu, Ly; Handoko, M. Louis; Rain, Silvia; Ruiter, Gerrina; François, Charlène; Schalij, Ingrid; Dorfmüller, Peter; Simonneau, Gérald; Fadel, Elie; Perros, Frederic; Boonstra, Anco; et al. (American journal of respiratory and critical care medicine, 2012)
Keywords: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Angiotensin II Type 1 Receptor Blockers - pharmacology; Animals; Biological and medical sciences; Case-Control Studies; Cells, Cultured; Disease Progression; Endocrine system; Endothelium, Vascular; Enzymes; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary - drug therapy; Hypertension, Pulmonary - physiopathology; Intensive care medicine; Kinases; Losartan - pharmacology; Lung transplants; Male; Medical sciences; Middle Aged; Monocrotaline; Mortality; Myocytes, Smooth Muscle; Nervous system; Pneumology; Pneumonectomy; Polymorphism; Proportional Hazards Models; Pulmonary arteries; Pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Rats; Receptor, Angiotensin, Type 1 - metabolism; Renin-Angiotensin System - drug effects; Smooth muscle; Thoracic surgery; Up-Regulation; Veins & arteries; France; Endothelial cell; Intensive care; endothelial cells; Steroid hormone; Mineralocorticoid; Respiratory disease; Idiopathic; monocrotaline; Cardiovascular disease; Smooth muscle; Aldosterone; Pulmonary hypertension; idiopathic pulmonary arterial hypertension; smooth muscle cells; Renin angiotensin system; Adrenal hormone; Resuscitation