Gestational Diabetes Is Characterized by Reduced Mitochondrial Protein Expression and Altered Calcium Signaling Proteins in Skeletal Muscle

• Published in: PloS one Vol. 9; no. 9; p. e106872
• Main Authors: Boyle, Kristen E., Hwang, Hyonson, Janssen, Rachel C., DeVente, James M., Barbour, Linda A., Hernandez, Teri L., Mandarino, Lawrence J., Lappas, Martha, Friedman, Jacob E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.09.2014; Public Library of Science (PLoS)
• Subjects: Adenylate Kinase - metabolism; Adult; Biology and Life Sciences; Calcineurin; Calcium; Calcium homeostasis; Calcium Signaling; Calcium signalling; Cardiomyopathy; Dehydrogenases; Diabetes; Diabetes mellitus; Diabetes, Gestational - metabolism; Electron Transport; Electron transport chain; Enzymatic activity; Female; Fetuses; Gene expression; Gestational diabetes; Glucose; Glucose tolerance; Glucose Tolerance Test; Gynecology; Homeostasis; Hospitals; Humans; Insulin resistance; Lipid peroxidation; Lipids; Maternal & child health; Medicine; Medicine and Health Sciences; Metabolism; Mitochondria; Mitochondria - enzymology; Mitochondrial Proteins - metabolism; Muscle Proteins - metabolism; Muscle, Skeletal - metabolism; Muscles; Musculoskeletal system; NADH-ubiquinone oxidoreductase; Obesity; Obesity - metabolism; Obstetrics; Oxidation; Oxidative phosphorylation; Pathogenesis; Pediatrics; Phosphorylation; Physical activity; Postpartum; Preeclampsia; Pregnancy; Proteins; Proteomics; Public health; Regulators; Risk analysis; Risk factors; Rodents; Skeletal muscle; Womens health; Victoria Australia; Australia; United States > US; Colorado; Arizona

The rising prevalence of gestational diabetes mellitus (GDM) affects up to 18% of pregnant women with immediate and long-term metabolic consequences for both mother and infant. Abnormal glucose uptake and lipid oxidation are hallmark features of GDM prompting us to use an exploratory proteomics appr...