Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB

• Published in: PloS one Vol. 8; no. 2; p. e56407
• Main Authors: Zhu, Tao, Wang, Dao-xin, Zhang, Wei, Liao, Xiu-qing, Guan, Xian, Bo, Hong, Sun, Jia-yang, Huang, Ni-wen, He, Jing, Zhang, Yun-kun, Tong, Jing, Li, Chang-yi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.02.2013; Public Library of Science (PLoS)
• Subjects: Acute Lung Injury - drug therapy; Acute Lung Injury - genetics; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; Alveolar Epithelial Cells - pathology; Alveolar Epithelial Cells - ultrastructure; Alveoli; Andrographis; Animals; Binding sites; Biology; Bronchoalveolar Lavage Fluid; Cell adhesion & migration; Cell Count; Cell Survival - drug effects; Cell Survival - genetics; Cytokines - metabolism; Deactivation; Deoxyribonucleic acid; Diterpenes - pharmacology; Diterpenes - therapeutic use; DNA; DNA - metabolism; Down-Regulation - drug effects; Drug dosages; Edema; Epithelial cells; Gene expression; Gene Expression Regulation - drug effects; Herbal medicine; Hospitals; Hypoxia; In vitro methods and tests; In vivo methods and tests; Inactivation; Inflammation; Interleukin 6; Kinases; Laboratory animals; Leukocytes (neutrophilic); Lipopolysaccharides; Lungs; Macrophages; Male; Medicinal plants; Medicine; Mice; Mice, Inbred BALB C; NF-kappa B - metabolism; NF-κB protein; Pathogens; Peroxidase - metabolism; Phosphorylation; Pneumonia - complications; Pneumonia - drug therapy; Pneumonia - genetics; Pneumonia - pathology; Protective Agents - pharmacology; Protective Agents - therapeutic use; Protein Binding - drug effects; Protein Binding - genetics; Pulmonary Edema - complications; Pulmonary Edema - drug therapy; Pulmonary Edema - genetics; Pulmonary Edema - pathology; Respiratory distress syndrome; Rheumatoid arthritis; Rodents; Therapeutic applications; Traditional Chinese medicine; Transcription Factor RelA - metabolism; Tumor necrosis factor-α; Ultrastructure; Vascular cell adhesion molecule 1; Vascular Cell Adhesion Molecule-1 - genetics; Vascular Cell Adhesion Molecule-1 - metabolism; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; China

Nuclear factor-κB (NF-κB) is a central transcriptional factor and a pleiotropic regulator of many genes involved in acute lung injury. Andrographolide is found in the plant of Andrographis paniculata and widely used in Traditional Chinese Medicine, exhibiting potently anti-inflammatory property by i...