Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities

• Published in: PloS one Vol. 8; no. 3; p. e58398
• Main Authors: Fu, Ru-Huei, Wang, Yu-Chi, Liu, Shih-Ping, Chu, Ching-Liang, Tsai, Rong-Tzong, Ho, Yu-Chen, Chang, Wen-Lin, Chiu, Shao-Chih, Harn, Horng-Jyh, Shyu, Woei-Cherng, Lin, Shinn-Zong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.03.2013; Public Library of Science (PLoS)
• Subjects: Activation; Animals; Antigens; Apoptosis; Autoimmune diseases; Berberine Alkaloids - pharmacology; Biology; Blockage; Bone marrow; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; CD40 antigen; CD86 antigen; Cell Membrane - metabolism; Cell Movement; Cell proliferation; Cell Survival; Chemokines; Chinese medicine; Corydalis - metabolism; Cytokines; Cytotoxicity; Dendritic cells; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - metabolism; Endocytosis; Flow cytometry; Gene expression; Hospitals; Hypersensitivity; Hypersensitivity (delayed); I-kappa B Kinase - metabolism; Immune system; Immunology; Immunomodulation; Immunosuppressive agents; Inflammation; Interleukin 6; Interleukin-12 - metabolism; Interleukin-6 - metabolism; Kinases; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Lymphocytes T; Major histocompatibility complex; MAP kinase; Maturation; Medicine; Mice; Mitogen-Activated Protein Kinases - metabolism; Modulators; Pathogens; Pharmacology; Plant Extracts - pharmacology; Protein kinase; Proteins; Signal transduction; T cell receptors; Toxicity; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Taiwan

Dendritic cells (DCs) are major modulators in the immune system. One active field of research is the manipulation of DCs as pharmacological targets to screen novel biological modifiers for the treatment of inflammatory and autoimmune disorders. Acetylcorynoline is the major alkaloid component derive...