Long-Term Suppressive Effect of Octreotide on Progression of Metastatic Gastrinoma with Multiple Endocrine Neoplasia Type 1: Seven-Year Follow up
A 30-year-old woman had a history of prolactinoma and primary hyperparathyroidism. She was diagnosed as having multiple endocrine neoplasia type 1 with gastrinoma and liver metastases. Octreotide therapy was started and the serum gastrin level decreased immediately. Octreotide continued to suppress...
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| Published in | Internal Medicine Vol. 49; no. 15; pp. 1557 - 1563 |
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| Abstract | A 30-year-old woman had a history of prolactinoma and primary hyperparathyroidism. She was diagnosed as having multiple endocrine neoplasia type 1 with gastrinoma and liver metastases. Octreotide therapy was started and the serum gastrin level decreased immediately. Octreotide continued to suppress gastrin secretion over the next 7 years. The Ki67/MIB1 proliferation index of this tumor was only 0.5 % and somatostatin receptor (SSTR) 2 expression was very strong in both 2002 and 2009. This case suggests the importance of investigating the Ki67/MIB1 index and SSTR expression in patients with metastatic gastrinoma. |
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| AbstractList | A 30-year-old woman had a history of prolactinoma and primary hyperparathyroidism. She was diagnosed as having multiple endocrine neoplasia type 1 with gastrinoma and liver metastases. Octreotide therapy was started and the serum gastrin level decreased immediately. Octreotide continued to suppress gastrin secretion over the next 7 years. The Ki67/MIB1 proliferation index of this tumor was only 0.5 % and somatostatin receptor (SSTR) 2 expression was very strong in both 2002 and 2009. This case suggests the importance of investigating the Ki67/MIB1 index and SSTR expression in patients with metastatic gastrinoma. |
| Author | Yamada, Yuya Tamba, Sachiko Hoshida, Yoshihiko Matsuzawa, Yuji Yamamoto, Koji Hosokawa, Yoshiya Ihara, Arisa Iwamoto, Ryuya Yamaguchi, Megu |
| Author_xml | – sequence: 1 fullname: Yamaguchi, Megu – sequence: 2 fullname: Yamada, Yuya – sequence: 3 fullname: Hosokawa, Yoshiya – sequence: 4 fullname: Iwamoto, Ryuya – sequence: 5 fullname: Tamba, Sachiko – sequence: 6 fullname: Ihara, Arisa – sequence: 7 fullname: Yamamoto, Koji – sequence: 8 fullname: Hoshida, Yoshihiko – sequence: 9 fullname: Matsuzawa, Yuji |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20686291$$D View this record in MEDLINE/PubMed |
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| Title | Long-Term Suppressive Effect of Octreotide on Progression of Metastatic Gastrinoma with Multiple Endocrine Neoplasia Type 1: Seven-Year Follow up |
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