The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis

• Published in: PloS one Vol. 8; no. 6; p. e65863
• Main Authors: Guo, Lu, Zhang, Li-Li, Zheng, Bo, Liu, Yun, Cao, Xiao-Jie, Pi, Yan, Li, Bing-Hu, Li, Jing-Cheng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.06.2013; Public Library of Science (PLoS)
• Subjects: Biology; Case-Control Studies; Confidence intervals; Diabetes; Epidemiology; Full text databases; Gene Frequency; Gene polymorphism; Genes; Genetic Association Studies; Genetic Predisposition to Disease; Heterogeneity; Heterotrimeric GTP-Binding Proteins - genetics; Hospitals; Humans; Hypertension; Hypertension - genetics; Lists; Medical ethics; Medicine; Meta-analysis; Neurology; Polymorphism; Polymorphism, Single Nucleotide; Population; Population studies; Proteins; Regression analysis; Sensitivity analysis; Signal transduction; Stability analysis; Statistical analysis; Stroke; Stroke - genetics; Studies; Surgery; China

Several epidemiological studies have evaluated the association between the GNB3 C825T polymorphism and hypertension or stroke. The results of these studies were inconsistent; therefore, we performed a meta-analysis to clarify these discrepancies. We systematically searched the PubMed, Embase, Web of...