XRCC1 gene variants and possible links with chromosome aberrations and micronucleus in active and passive smokers

• Published in: Environmental toxicology and pharmacology Vol. 32; no. 2; pp. 185 - 192
• Main Authors: Chandirasekar, R., Suresh, K., Jayakumar, R., Venkatesan, R., Lakshman Kumar, B., Sasikala, K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2011
• Subjects: Cancer; Case-Control Studies; Cells, Cultured; Chromosomal aberrations; chromosome aberrations; Chromosome Aberrations - chemically induced; chromosomes; Cytogenetics; Cytogenetics - methods; death; DNA Damage; DNA-Binding Proteins - genetics; Emergency; Epithelial Cells - physiology; exposure duration; Female; genes; genotoxicity; Genotype; Humans; Lymphocytes - cytology; Lymphocytes - physiology; Male; Micronuclei, Chromosome-Defective - chemically induced; Mouth Mucosa - cytology; myocardial infarction; neoplasms; Occupational Exposure; Polymorphism; Polymorphism, Single Nucleotide; risk; single nucleotide polymorphism; smoking (habit); Smoking - adverse effects; tobacco; Tobacco addictive; Tobacco Smoke Pollution - adverse effects; toxins; X-ray Repair Cross Complementing Protein 1; MN; AS; BMN; PS; CAs; BLMN; Chromosomal aberrations; Tobacco addictive; Cytogenetics; Cancer; Polymorphism; Blood lymphocyte micronuclei; Active smokers; Micronuclei; Passive smokers; Buccal micronuclei

► The present investigation was conducted to analyze the genotoxic effects of tobacco on active and passive smokers. ► Three types of genetic test methods were employed including chromosome, micronucleus and XRCC1 arg399gln polymorphism. ► A high level of chromosomal aberrations and micronucleus wer...