HIV DNA Reservoir Increases Risk for Cognitive Disorders in cART-Naïve Patients

• Published in: PloS one Vol. 8; no. 7; p. e70164
• Main Authors: Valcour, Victor G., Ananworanich, Jintanat, Agsalda, Melissa, Sailasuta, Napapon, Chalermchai, Thep, Schuetz, Alexandra, Shikuma, Cecilia, Liang, Chin-Yuan, Jirajariyavej, Supunee, Sithinamsuwan, Pasiri, Tipsuk, Somporn, Clifford, David B., Paul, Robert, Fletcher, James L. K., Marovich, Mary A., Slike, Bonnie M., DeGruttola, Victor, Shiramizu, Bruce
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.07.2013; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Activation; Adult; AIDS; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiretroviral Therapy, Highly Active; Biology; Blood cells; Brain; Brain - metabolism; Brain - pathology; Brain - virology; Brain injury; Brain research; CD14 antigen; CD4 antigen; Cell number; Cerebrospinal fluid; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Cognitive ability; Consent; Copy number; Cytokines; Cytokines - blood; Cytokines - cerebrospinal fluid; Deoxyribonucleic acid; DNA; DNA, Viral - genetics; DNA, Viral - metabolism; Drug therapy; Enrichment; Female; Head injuries; Health risks; HIV; HIV - drug effects; HIV - genetics; HIV - physiology; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - virology; Hospitals; Host-Pathogen Interactions - drug effects; Human immunodeficiency virus; Humans; Immune response; Impairment; Infections; Lipopolysaccharide Receptors - metabolism; Lymphocytes; Lymphocytes T; Magnetic resonance; Magnetic resonance spectroscopy; Male; Markers; Medicine; Monocytes; Monocytes - metabolism; Monocytes - pathology; Monocytes - virology; Multiplex Polymerase Chain Reaction; Multivariate Analysis; N-Acetylaspartate; Neopterin; Neurology; Neuronal-glial interactions; Peripheral blood; Prospective Studies; Public health; Regression Analysis; Reservoirs; Ribonucleic acid; Risk Factors; RNA; ROC Curve; Spectroscopy; Spectrum analysis; Studies; Viruses; San Francisco California; United States > US; Missouri; Hawaii; California; Thailand; Bangkok Thailand
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0070164

Cognitive impairment remains frequent in HIV, despite combination antiretroviral therapy (cART). Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain. These reservoirs remain present despite cART. The objective of this study was to det...