The microbiota metabolite indole inhibits Salmonella virulence: Involvement of the PhoPQ two-component system

• Published in: PloS one Vol. 13; no. 1; p. e0190613
• Main Authors: Kohli, Nandita, Crisp, Zeni, Riordan, Rebekah, Li, Michael, Alaniz, Robert C, Jayaraman, Arul
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2018; Public Library of Science (PLoS)
• Subjects: Antibiotics; Bacteria; Biofilms; Biology and Life Sciences; Cell survival; Chemical engineering; Colonization; Drug dosages; E coli; Epithelial cells; Escherichia coli; Fatty acids; Gastrointestinal tract; Gene expression; Immunology; Indoles; Infections; Intestine; Macrophages; Medicine and Health Sciences; Metabolites; Microbiota; Microorganisms; Motility; Organs; Pathogenesis; Pathogenicity; Pathogens; Physical Sciences; Salmonella; Salmonella enterica; Solvents; Tryptophan; Virulence

The microbial community present in the gastrointestinal tract is an important component of the host defense against pathogen infections. We previously demonstrated that indole, a microbial metabolite of tryptophan, reduces enterohemorrhagic Escherichia coli O157:H7 attachment to intestinal epithelia...