Icariin Ameliorates Cigarette Smoke Induced Inflammatory Responses via Suppression of NF-κB and Modulation of GR In Vivo and In Vitro - Li, Lulu; Sun, Jing; Xu, Changqing; Zhang, Hongying; Wu, Jinfeng; Liu, Baojun; Dong, Jingcheng (PloS one, 2014)
Keywords: Airway management; Animal models; Animals; Asthma; Biology and Life Sciences; Cell Line, Tumor; Chronic illnesses; Chronic obstructive pulmonary disease; Cigarette smoke; Cigarette smoking; Cigarettes; Critical care; Dexamethasone; Exposure; Flavonoids; Flavonoids - chemistry; Flavonoids - pharmacology; Gelatinase B; Gene expression; Gene Expression Regulation - drug effects; Hospitals; Humans; In vitro methods and tests; In vivo methods and tests; Inflammation; Inflammation - genetics; Inflammation - pathology; Inflammatory diseases; Inflammatory response; Interleukin 8; Interleukin-8 - metabolism; Lung - drug effects; Lung - pathology; Lung - physiopathology; Lung diseases; Lungs; Male; Matrix Metalloproteinase 9 - metabolism; Medicine; Medicine and Health Sciences; Mice; Mice, Inbred BALB C; Neutrophils; NF-kappa B - metabolism; NF-κB protein; Oxidative stress; Phosphorylation; Pulmonary functions; Receptors, Glucocorticoid - genetics; Receptors, Glucocorticoid - metabolism; Research and Analysis Methods; Respiratory function; Respiratory Function Tests; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Smoke; Smoking; Smoking - adverse effects; Synaptotagmin; Transcription factors; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; United States--US; China