Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells

• Published in: PloS one Vol. 7; no. 4; p. e36006
• Main Authors: Tseng, Ho-Hsing, Chuah, Qiu-Yu, Yang, Pei-Ming, Chen, Chiung-Tong, Chao, Jung-Chi, Lin, Ming-Der, Chiu, Shu-Jun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.04.2012; Public Library of Science (PLoS)
• Subjects: Activation; Androgens; Angiogenesis; Anticancer properties; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Binding sites; Biocompatibility; Biology; Cancer; Cancer therapies; Caspase; Caspases - metabolism; Cdc2 protein; CDC2 Protein Kinase - metabolism; Cell cycle; Cell death; Cell division; Cell proliferation; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; DNA Repair - drug effects; G2 Phase Cell Cycle Checkpoints - drug effects; Gene expression; Genomes; HCT116 Cells; Humans; Indoles; Indoles - pharmacology; JNK Mitogen-Activated Protein Kinases - metabolism; JNK protein; Kinases; Life sciences; M Phase Cell Cycle Checkpoints - drug effects; MAP kinase; Medicine; Metastasis; Mortality; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Null cells; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation; Phosphorylation - drug effects; Proteins; Securin; Senescence; Studies; Toxicity; Tumorigenesis; Tumors; Taiwan

BPR0L075 [6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole] is a novel anti-microtubule drug with anti-tumor and anti-angiogenic activities in vitro and in vivo. Securin is required for genome stability, and is expressed abundantly in most cancer cells, promoting cell proliferation...