Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content

• Published in: PloS one Vol. 10; no. 5; p. e0128398
• Main Authors: Goodman, Craig A, Pol, Derk, Zacharewicz, Evelyn, Lee-Young, Robert S, Snow, Rod J, Russell, Aaron P, McConell, Glenn K
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.05.2015; Public Library of Science (PLoS)
• Subjects: Animals; Atrophy; Drugs; Fatty acids; Gene expression; Gene Expression Regulation - drug effects; Genes; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Kinases; Male; Markers; Mitochondria; Mitochondria, Muscle - metabolism; Mitochondria, Muscle - pathology; Muscle Proteins - biosynthesis; Muscles; Muscular Atrophy - metabolism; Muscular Atrophy - pathology; Myopathy; Myostatin; Nitric oxide; Nitric-oxide synthase; Nutrition; Oxidation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Regulators; Side effects; Simvastatin; Simvastatin - pharmacology; Skeletal muscle; Statins; Transcription activation; Transcription Factors - metabolism

One serious side effect of statin drugs is skeletal muscle myopathy. Although the mechanism(s) responsible for statin myopathy remains to be fully determined, an increase in muscle atrophy gene expression and changes in mitochondrial content and/or function have been proposed to play a role. In this...