Impact of combined clenbuterol and metoprolol therapy on reverse remodelling during mechanical unloading

• Published in: PloS one Vol. 9; no. 9; p. e92909
• Main Authors: Navaratnarajah, Manoraj, Siedlecka, Urszula, Ibrahim, Michael, van Doorn, Carin, Soppa, Gopal, Gandhi, Ajay, Shah, Adarsh, Kukadia, Punam, Yacoub, Magdi H, Terracciano, Cesare M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.09.2014; Public Library of Science (PLoS)
• Subjects: Adrenergic beta-1 Receptor Antagonists - pharmacology; Adrenergic beta-2 Receptor Agonists - pharmacology; Adrenergic receptors; Animals; Atrophy; Biology and Life Sciences; Calcium (reticular); Calcium - metabolism; Calcium signalling; Cardiovascular disease; Chronic effects; Clenbuterol; Clenbuterol - pharmacology; Contraction; Coronary artery; Coupling; Cytology; Drug therapy; Drug Therapy, Combination; Excitation Contraction Coupling - drug effects; Gene expression; Heart diseases; Heart failure; Heart Failure - drug therapy; Heart Failure - metabolism; Heart Failure - pathology; Heart Failure - physiopathology; Heart Rate - drug effects; Heart Transplantation; Hypertrophy; Laboratory animals; Male; Mechanical unloading; Medicine and Health Sciences; Metoprolol; Metoprolol - pharmacology; Myocardium - metabolism; Myocardium - pathology; Ostomy; Physiology; Rats; Rats, Inbred Lew; Receptors, Adrenergic, beta-1 - metabolism; Receptors, Adrenergic, beta-2 - metabolism; Recovery; Remodeling; Research and Analysis Methods; Rodents; Sarcoplasmic reticulum; Science; Stroke Volume - drug effects; Structure-function relationships; Studies; Tachycardia; Therapy; Transplantation; Transplantation, Heterotopic; Unloading; Ventricle; Ventricular Function, Left - drug effects; Ventricular Remodeling - drug effects; United Kingdom > UK

Clenbuterol (Cl), a β2 agonist, is associated with enhanced myocardial recovery during left ventricular assist device (LVAD) support, and exerts beneficial remodelling effects during mechanical unloading (MU) in rodent heart failure (HF). However, the specific effects of combined Cl+β1 blockade duri...