Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques

• Published in: PloS one Vol. 13; no. 12; p. e0209830
• Main Authors: Branavan, Umayal, Muneeswaran, Kajan, Wijesundera, Sulochana, Jayakody, Surangi, Chandrasekharan, Vishvanath, Wijeyaratne, Chandrika
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.12.2018; Public Library of Science (PLoS)
• Subjects: Adolescents; Adult; Age; Alleles; Assaying; Biology and Life Sciences; Body fat; Child development; Collaboration; Deoxyribonucleic acid; DNA; Endocrinology; Female; Follicle-stimulating hormone; Fto gene; Gene polymorphism; Gene sequencing; Genes; Genetic Predisposition to Disease - genetics; Genotype; Genotyping; Gonadotropins; Gynecology; Humans; Insulin; Luteinizing hormone; Medicine; Medicine and Health Sciences; Menstruation; Mutation; Obstetrics; Physical Sciences; Pituitary (anterior); Polycystic ovary syndrome; Polycystic Ovary Syndrome - genetics; Polymorphism; Polymorphism, Single Nucleotide - genetics; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Sensitivity analysis; Single-nucleotide polymorphism; Sri Lanka; Ultrasonic imaging; Young Adult; Sri Lanka

Polycystic ovary syndrome (PCOS), the commonest endocrine disorder affecting young women, appears to be a multigenic trait with contributing genes being unclear. Hence, analysis of polymorphisms in multiple candidate genes is required. Currently available genotyping methods are expensive, time-consu...