DaHuangWan targets EGF signaling to inhibit the proliferation of hepatoma cells

• Published in: PloS one Vol. 15; no. 4; p. e0231466
• Main Authors: Si, Ha, Genna, Ba, Zhuang, Xiangjin, Wang, Jing, Burenbatu, B., Feng, Qiyu, Wang, Hongyang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.04.2020; Public Library of Science (PLoS)
• Subjects: Anticancer properties; Berberine; Biology and Life Sciences; Breast cancer; Cancer therapies; Cell culture; Cell cycle; Cell growth; Cell membranes; Cell proliferation; Endocytosis; Epidermal growth factor; Epidermal growth factor receptors; Ethanol; Fibroblast growth factor 2; Growth factors; Hepatoma; Herbal medicine; Herbs; Homeostasis; Hospitals; Kinases; Ligands; Liver cancer; Lung cancer; Medicine and Health Sciences; Optimization; Phosphorylation; Protein turnover; Protein-tyrosine kinase; Quality of life; Research and Analysis Methods; Side effects; Signal transduction; Signaling; Surgery; Synergistic effect; Tumors; Tyrosine; Ubiquitination; China; Inner Mongolia China

DaHuangWan (DHW) is a traditional herbal medicine used by Mongolian to treat liver cancer for many years. Clinical application of the drug has been shown to help control tumor progression, prolong survival and improve quality of life. However, the underlying mechanisms and side effects of this drug...