Plasma Amyloid-β, Total Tau, and Neurofilament Light Chain Across the Alzheimer's Disease Clinical Spectrum: A Population-Based Study

• Published in: Journal of Alzheimer's disease Vol. 96; no. 2; p. 845
• Main Authors: Dong, Yi, Hou, Tingting, Li, Yuanjing, Liu, Rui, Cong, Lin, Liu, Keke, Liu, Cuicui, Han, Xiaolei, Ren, Yifei, Tang, Shi, Winblad, Bengt, Blennow, Kaj, Wang, Yongxiang, Du, Yifeng, Qiu, Chengxuan
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2023
• Subjects: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E - genetics; Biomarkers; Cognitive Dysfunction; Female; Humans; Intermediate Filaments; Male; Middle Aged; tau Proteins; plasma biomarkers; diagnostic accuracy; mild cognitive impairment; Alzheimer’s disease; population-based study

Plasma biomarkers have emerged as a promising approach for characterizing pathophysiology in mild cognitive impairment (MCI) and Alzheimer's disease (AD). We aimed to characterize plasma biomarkers for AD and neurodegeneration across the AD clinical continuum, and to assess their ability to dif...