Mechanism of Phagolysosome Biogenesis Block by Viable Mycobacterium tuberculosis
Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3-phosphate (...
Saved in:
| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 11; pp. 4033 - 4038 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
15.03.2005
National Acad Sciences |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents, is retained on phagosomes harboring dead mycobacteria but is continuously eliminated from phagosomes with live bacilli. We show that the exclusion of PI3P from live mycobacterial phagosomes can be only transiently reversed by Ca2+fluxes, and that live M. tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation. |
|---|---|
| AbstractList | Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents, is retained on phagosomes harboring dead mycobacteria but is continuously eliminated from phagosomes with live bacilli. We show that the exclusion of PI3P from live mycobacterial phagosomes can be only transiently reversed by Ca2+ fluxes, and that live M. tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation. [PUBLICATION ABSTRACT] Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3- phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents, is retained on phagosomes harboring dead mycobacteria but is continuously eliminated from phagosomes with live bacilli. We show that the exclusion of PI3P from live mycobacterial phagosomes can be only transiently reversed by Ca super(2+) fluxes, and that live M. tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation. Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents, is retained on phagosomes harboring dead mycobacteria but is continuously eliminated from phagosomes with live bacilli. We show that the exclusion of PI3P from live mycobacterial phagosomes can be only transiently reversed by Ca2+ fluxes, and that live M. tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation. Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents, is retained on phagosomes harboring dead mycobacteria but is continuously eliminated from phagosomes with live bacilli. We show that the exclusion of PI3P from live mycobacterial phagosomes can be only transiently reversed by Ca 2+ fluxes, and that live M. tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome–late endosome fusion in vitro , and contributes to inhibition of phagosomal maturation. macrophage phagosome tuberculosis lysosome phosphatidylinositol 3-phosphate Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents, is retained on phagosomes harboring dead mycobacteria but is continuously eliminated from phagosomes with live bacilli. We show that the exclusion of PI3P from live mycobacterial phagosomes can be only transiently reversed by Ca2+ fluxes, and that live M. tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation.Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents, is retained on phagosomes harboring dead mycobacteria but is continuously eliminated from phagosomes with live bacilli. We show that the exclusion of PI3P from live mycobacterial phagosomes can be only transiently reversed by Ca2+ fluxes, and that live M. tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation. Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays, we report the principal difference between phagosomes containing live and dead mycobacteria. Phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents, is retained on phagosomes harboring dead mycobacteria but is continuously eliminated from phagosomes with live bacilli. We show that the exclusion of PI3P from live mycobacterial phagosomes can be only transiently reversed by Ca 2+ fluxes, and that live M. tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome–late endosome fusion in vitro , and contributes to inhibition of phagosomal maturation. |
| Author | Deretic, Vojo Collier, R. John Lucas, Megan Chua, Jennifer Lee, Hwang-Ho Vergne, Isabelle Belisle, John |
| AuthorAffiliation | Departments of Molecular Genetics and Microbiology and § Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131; and ‡ Department of Microbiology, Colorado State University, Fort Collins, CO 80523 |
| AuthorAffiliation_xml | – name: Departments of Molecular Genetics and Microbiology and § Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131; and ‡ Department of Microbiology, Colorado State University, Fort Collins, CO 80523 |
| Author_xml | – sequence: 1 givenname: Isabelle surname: Vergne fullname: Vergne, Isabelle – sequence: 2 givenname: Jennifer surname: Chua fullname: Chua, Jennifer – sequence: 3 givenname: Hwang-Ho surname: Lee fullname: Lee, Hwang-Ho – sequence: 4 givenname: Megan surname: Lucas fullname: Lucas, Megan – sequence: 5 givenname: John surname: Belisle fullname: Belisle, John – sequence: 6 givenname: Vojo surname: Deretic fullname: Deretic, Vojo – sequence: 7 givenname: R. John surname: Collier fullname: Collier, R. John |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15753315$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkb1vFDEQxS0URC6BmgbBigLRXDL-Wu8WFCTiS0pECqC1vL7ZOx_e9WF7Efffs6s7cpAiVFPM77159jshR33okZCnFM4oKH6-6U06AwG1oiUF9oDMKNR0XooajsgMgKl5JZg4JicprQGglhU8IsdUKsk5lTNyc412ZXqXuiK0xc3KLIPfppBCh8WFC0vsMblUXPhgvxfNtvjmTOOxuN7a0BibMbqhK_LQYLSDDyP6mDxsjU_4ZD9Pydf3775cfpxfff7w6fLt1dxKVua5pEYuLBiuQLastbxqAKVsqBC8VFxasKYGY1uFgrFaVcY0oBAXLTdGVTU_JW92vpuh6XBhsc_ReL2JrjNxq4Nx-t9N71Z6GX5qKUXF2Kh_tdfH8GPAlHXnkkXvTY9hSLpUkrGKwn9BqpgqpZocX94B12GI_fgJmgHlAGU9uT3_O_Zt3j-NjMD5DrAxpBSxPSCgp8711Lk-dD4q5B2FddlkF6Z3O3-P7vU-yrQ4XGGaUi2Ac90O3mf8lUf0xf3oSDzbEeuUQ7xFOFeiKin_DZAv0uE |
| CitedBy_id | crossref_primary_10_1016_j_micinf_2007_09_007 crossref_primary_10_1016_j_ddmec_2006_06_010 crossref_primary_10_1016_j_semcdb_2020_01_007 crossref_primary_10_1155_2011_403623 crossref_primary_10_1111_j_1574_6976_2012_00331_x crossref_primary_10_1111_j_1742_4658_2006_05543_x crossref_primary_10_1111_j_1600_065X_2007_00547_x crossref_primary_10_1016_j_bbrc_2015_04_051 crossref_primary_10_1042_BST0381417 crossref_primary_10_1002_bies_201000152 crossref_primary_10_1016_j_mib_2005_12_014 crossref_primary_10_1093_infdis_jiy033 crossref_primary_10_1038_ncomms9745 crossref_primary_10_2217_fmb_15_11 crossref_primary_10_1016_j_mib_2005_12_007 crossref_primary_10_1083_jcb_200603026 crossref_primary_10_1016_j_ijbiomac_2020_03_037 crossref_primary_10_1111_j_1462_5822_2005_00580_x crossref_primary_10_1128_microbiolspec_GPP3_0022_2018 crossref_primary_10_1371_journal_ppat_1003499 crossref_primary_10_1111_j_1865_1682_2009_01072_x crossref_primary_10_2217_imt_12_52 crossref_primary_10_3390_vaccines12050530 crossref_primary_10_1111_j_1469_0691_2009_03011_x crossref_primary_10_1080_21541248_2016_1240494 crossref_primary_10_3389_fimmu_2020_592333 crossref_primary_10_3390_ijms252212481 crossref_primary_10_1016_j_tube_2015_05_011 crossref_primary_10_18699_SSMJ20220605 crossref_primary_10_1128_JB_00505_20 crossref_primary_10_1378_chest_13_1232 crossref_primary_10_1111_febs_16369 crossref_primary_10_1371_journal_pone_0094418 crossref_primary_10_1128_iai_00217_24 crossref_primary_10_3389_fimmu_2018_00086 crossref_primary_10_1186_s12864_015_1569_2 crossref_primary_10_1111_j_1574_6976_2011_00276_x crossref_primary_10_3389_fimmu_2023_1227467 crossref_primary_10_1128_IAI_05987_11 crossref_primary_10_1016_j_tcb_2012_04_005 crossref_primary_10_4049_jimmunol_1301686 crossref_primary_10_1016_j_mib_2013_10_007 crossref_primary_10_1128_IAI_00916_19 crossref_primary_10_3389_fimmu_2021_636078 crossref_primary_10_1128_IAI_01108_10 crossref_primary_10_2217_fmb_14_29 crossref_primary_10_1089_dna_2014_2745 crossref_primary_10_1128_IAI_00997_06 crossref_primary_10_1371_journal_ppat_0010033 crossref_primary_10_1128_microbiolspec_MGM2_0020_2013 crossref_primary_10_1111_j_1462_5822_2009_01324_x crossref_primary_10_1128_MMBR_00032_13 crossref_primary_10_1128_CVI_00015_11 crossref_primary_10_1159_000497414 crossref_primary_10_1111_j_1600_065X_2010_00984_x crossref_primary_10_1021_acsinfecdis_5b00099 crossref_primary_10_1371_journal_pone_0031788 crossref_primary_10_1016_j_imbio_2006_06_004 crossref_primary_10_1242_bio_023119 crossref_primary_10_1002_jcb_23218 crossref_primary_10_2217_17460913_3_5_517 crossref_primary_10_1002_med_21588 crossref_primary_10_1016_j_micinf_2017_06_008 crossref_primary_10_1080_21505594_2020_1869441 crossref_primary_10_1016_j_jctube_2022_100300 crossref_primary_10_1038_srep37975 crossref_primary_10_1186_s44149_024_00128_9 crossref_primary_10_1016_j_tube_2019_01_003 crossref_primary_10_1038_srep18961 crossref_primary_10_1189_jlb_1MR0114_021R crossref_primary_10_4049_jimmunol_1202900 crossref_primary_10_1042_BJ20071427 crossref_primary_10_1155_2019_2471215 crossref_primary_10_1371_journal_pone_0153932 crossref_primary_10_1111_cmi_13008 crossref_primary_10_1189_jlb_1A0716_305R crossref_primary_10_3389_fimmu_2023_1238132 crossref_primary_10_1016_j_cell_2007_04_043 crossref_primary_10_1016_j_chom_2013_01_008 crossref_primary_10_1002_wsbm_1643 crossref_primary_10_3389_fncel_2015_00182 crossref_primary_10_1016_j_vaccine_2008_07_019 crossref_primary_10_1371_journal_ppat_1007011 crossref_primary_10_4049_jimmunol_1000801 crossref_primary_10_1038_s41598_017_18547_9 crossref_primary_10_1016_j_copbio_2019_10_011 crossref_primary_10_1080_21505594_2015_1102832 crossref_primary_10_1016_j_chom_2008_05_006 crossref_primary_10_1042_BJ20140361 crossref_primary_10_3389_fmicb_2017_02284 crossref_primary_10_3389_fcimb_2014_00157 crossref_primary_10_1016_j_crchbi_2022_100030 crossref_primary_10_1038_s41551_020_00665_x crossref_primary_10_3389_fmicb_2020_570794 crossref_primary_10_1038_sj_emboj_7601407 crossref_primary_10_1016_j_bbapap_2020_140470 crossref_primary_10_1080_07391102_2019_1677499 crossref_primary_10_1128_microbiolspec_TBTB2_0001_2015 crossref_primary_10_1146_annurev_pathol_042120_032916 crossref_primary_10_1093_intimm_dxl029 crossref_primary_10_1186_1465_9921_10_60 crossref_primary_10_4199_C00081ED1V01Y201304BBC004 crossref_primary_10_1042_BJ20140916 crossref_primary_10_1155_2019_1356540 crossref_primary_10_1038_nrmicro3200 crossref_primary_10_1172_JCI35433 crossref_primary_10_3389_fphar_2019_00022 crossref_primary_10_1074_jbc_M113_474239 crossref_primary_10_1186_s44280_024_00065_9 crossref_primary_10_1371_journal_ppat_1010771 crossref_primary_10_3389_fcimb_2020_595029 crossref_primary_10_1134_S2079086416020067 crossref_primary_10_1126_science_abq0132 crossref_primary_10_1128_microbiolspec_GPP3_0043_2018 crossref_primary_10_1139_bcb_2017_0317 crossref_primary_10_1080_19420889_2016_1174798 crossref_primary_10_3390_ijms23147750 crossref_primary_10_1016_j_ijtb_2023_05_012 crossref_primary_10_1128_microbiolspec_MCHD_0012_2015 crossref_primary_10_3389_fimmu_2022_946929 crossref_primary_10_7554_eLife_40063 crossref_primary_10_1111_cmi_12217 crossref_primary_10_24998_maeusabed_324841 crossref_primary_10_3389_fmicb_2018_00070 crossref_primary_10_15789_2220_7619_2014_4_319_330 crossref_primary_10_1586_eri_12_95 crossref_primary_10_1186_1297_9716_45_54 crossref_primary_10_1038_s41598_019_44449_z crossref_primary_10_1074_jbc_M112_373209 crossref_primary_10_1016_j_vaccine_2014_04_084 crossref_primary_10_1038_nrmicro2128 crossref_primary_10_1038_s41392_024_02043_4 crossref_primary_10_1128_MMBR_00003_07 crossref_primary_10_1186_s12866_017_1102_7 crossref_primary_10_1107_S139900471401092X crossref_primary_10_1186_1471_2164_11_457 crossref_primary_10_1016_j_bbrep_2021_101041 crossref_primary_10_3389_fimmu_2017_01836 crossref_primary_10_1007_s00018_016_2422_8 crossref_primary_10_3389_fimmu_2021_740117 crossref_primary_10_3390_microorganisms10091865 crossref_primary_10_3390_molecules25163760 crossref_primary_10_1039_D2TB01764D crossref_primary_10_1096_fj_13_235507 crossref_primary_10_1111_j_1365_2958_2009_06608_x crossref_primary_10_1111_j_1600_0854_2012_01398_x crossref_primary_10_1002_emmm_201000125 crossref_primary_10_3389_fimmu_2018_00193 crossref_primary_10_3390_vaccines1010034 crossref_primary_10_1136_thoraxjnl_2015_207052 crossref_primary_10_1242_bio_016485 crossref_primary_10_1136_thoraxjnl_2021_217997 crossref_primary_10_1111_j_1462_5822_2007_01067_x crossref_primary_10_1038_s42003_022_03387_9 crossref_primary_10_1016_j_ijid_2009_11_016 crossref_primary_10_1080_21505594_2022_2150449 crossref_primary_10_1038_nrd1776 crossref_primary_10_1172_JCI148136 crossref_primary_10_1016_j_str_2005_07_017 crossref_primary_10_1111_j_1462_5822_2008_01147_x crossref_primary_10_1038_s41598_024_61815_8 crossref_primary_10_1038_s41598_018_24509_6 crossref_primary_10_1371_journal_ppat_1002212 crossref_primary_10_3390_microorganisms7030070 crossref_primary_10_3389_fimmu_2022_938895 crossref_primary_10_1159_000500470 crossref_primary_10_1016_j_sjbs_2021_10_002 crossref_primary_10_1002_jcp_26503 crossref_primary_10_3389_fimmu_2024_1321657 crossref_primary_10_3390_ijms23010144 crossref_primary_10_3389_fcimb_2015_00048 crossref_primary_10_1016_j_imbio_2008_12_005 crossref_primary_10_2217_fmb_13_140 crossref_primary_10_3390_antibiotics10121515 crossref_primary_10_1038_emboj_2009_159 crossref_primary_10_1152_physrev_00028_2012 crossref_primary_10_4049_jimmunol_177_5_3250 crossref_primary_10_1038_nmicrobiol_2016_236 crossref_primary_10_1155_2011_814943 crossref_primary_10_1371_journal_pone_0087834 crossref_primary_10_3389_fimmu_2014_00455 crossref_primary_10_1007_s00005_009_0050_9 crossref_primary_10_1016_j_chembiol_2021_07_017 crossref_primary_10_1128_mSphere_00354_19 crossref_primary_10_1371_journal_ppat_1010061 crossref_primary_10_3389_fimmu_2022_943344 crossref_primary_10_1371_journal_pone_0148885 crossref_primary_10_1093_femspd_fty026 crossref_primary_10_2217_fmb_2021_0101 crossref_primary_10_1016_j_febslet_2006_07_007 crossref_primary_10_1016_j_tube_2014_01_001 crossref_primary_10_1093_femspd_ftac004 crossref_primary_10_1194_jlr_RA120000895 crossref_primary_10_1016_j_bbamem_2011_11_015 crossref_primary_10_1186_2193_1801_2_686 crossref_primary_10_1021_pr101245u crossref_primary_10_3389_fcimb_2020_595502 crossref_primary_10_1016_j_micinf_2012_07_001 crossref_primary_10_1038_nature04397 crossref_primary_10_1016_j_amjms_2018_12_003 crossref_primary_10_1016_j_vetimm_2014_03_013 crossref_primary_10_1016_j_micinf_2012_11_001 crossref_primary_10_1038_srep03527 crossref_primary_10_1134_S2079086416040058 crossref_primary_10_1002_emmm_200900008 crossref_primary_10_1165_rcmb_2010_0319OC crossref_primary_10_1016_j_bbapap_2009_09_008 crossref_primary_10_1016_j_ceb_2006_06_006 crossref_primary_10_1146_annurev_cellbio_100913_013439 crossref_primary_10_1093_femspd_fty037 crossref_primary_10_1177_0300985811429313 crossref_primary_10_1371_journal_ppat_1002551 crossref_primary_10_1074_mcp_RA117_000296 crossref_primary_10_1146_annurev_pharmtox_061008_103123 crossref_primary_10_1016_j_jtbi_2019_04_017 crossref_primary_10_1016_j_mehy_2014_04_002 crossref_primary_10_1242_jcs_200659 crossref_primary_10_1096_fj_08_114421 crossref_primary_10_1186_s12964_020_00677_9 crossref_primary_10_1371_journal_ppat_1004176 crossref_primary_10_1111_tra_12280 crossref_primary_10_1134_S1990519X23040090 crossref_primary_10_1038_nrmicro2602 crossref_primary_10_1111_j_1460_9568_2007_05618_x crossref_primary_10_1128_mbio_03221_22 crossref_primary_10_1073_pnas_1316376111 crossref_primary_10_4161_auto_20881 crossref_primary_10_1093_femsre_fuy013 crossref_primary_10_1093_intimm_dxp088 crossref_primary_10_15252_embr_202152864 crossref_primary_10_1007_s12026_008_8021_5 crossref_primary_10_1016_j_ijmyco_2016_02_001 crossref_primary_10_1091_mbc_E17_07_0464 crossref_primary_10_1002_cmdc_202400303 crossref_primary_10_1111_j_1462_5822_2006_00793_x crossref_primary_10_1080_15548627_2021_1938912 crossref_primary_10_1016_j_smim_2014_09_002 crossref_primary_10_3389_fcimb_2021_722433 crossref_primary_10_1038_s41598_019_46731_6 crossref_primary_10_1038_nrmicro2295 crossref_primary_10_3389_fcimb_2022_916247 crossref_primary_10_1016_j_ijmm_2019_06_004 crossref_primary_10_1080_21505594_2019_1584027 crossref_primary_10_1038_s41598_019_38982_0 crossref_primary_10_1016_j_bbrc_2015_09_124 crossref_primary_10_1111_j_1600_0463_2009_02458_x crossref_primary_10_3389_fimmu_2023_1233630 crossref_primary_10_1007_s12088_016_0625_1 crossref_primary_10_1021_acs_jproteome_9b00895 crossref_primary_10_1111_j_1462_5822_2006_00705_x crossref_primary_10_1128_mBio_01278_14 crossref_primary_10_1016_j_ncrna_2024_12_005 crossref_primary_10_1099_mic_0_2008_018895_0 crossref_primary_10_1378_chest_11_2348 crossref_primary_10_1038_514S2a crossref_primary_10_1111_j_1440_1843_2008_01350_x crossref_primary_10_1128_JB_00439_21 crossref_primary_10_1371_journal_ppat_1006459 crossref_primary_10_1016_j_febslet_2012_09_043 crossref_primary_10_1016_j_smim_2014_09_011 crossref_primary_10_1021_pr2008658 crossref_primary_10_1016_j_chom_2013_08_010 crossref_primary_10_3389_fcimb_2016_00035 crossref_primary_10_1098_rsob_150171 crossref_primary_10_3389_fimmu_2017_01368 crossref_primary_10_3389_fcimb_2023_1146571 crossref_primary_10_1016_j_micinf_2006_10_011 crossref_primary_10_1038_s41541_019_0122_8 crossref_primary_10_1371_journal_pone_0215123 crossref_primary_10_1093_infdis_jiy237 crossref_primary_10_1371_journal_ppat_0030186 crossref_primary_10_1074_jbc_RA119_009133 crossref_primary_10_1186_1752_0509_6_5 crossref_primary_10_1371_journal_ppat_1003734 crossref_primary_10_1111_imr_12268 crossref_primary_10_1371_journal_pone_0070514 crossref_primary_10_1111_j_1365_2249_2010_04146_x crossref_primary_10_1080_03014460_2023_2288008 crossref_primary_10_1080_21505594_2020_1726561 crossref_primary_10_1038_nature05185 crossref_primary_10_5582_ddt_2022_01104 crossref_primary_10_1084_jem_20051239 crossref_primary_10_1073_pnas_1013827107 crossref_primary_10_1128_microbiolspec_BAI_0022_2019 crossref_primary_10_1016_j_tim_2012_09_002 crossref_primary_10_4049_jimmunol_1301526 crossref_primary_10_1073_pnas_1522811113 crossref_primary_10_1016_j_plipres_2012_05_002 crossref_primary_10_1111_j_1462_5822_2010_01491_x crossref_primary_10_1002_iub_1737 crossref_primary_10_1002_eji_201041340 crossref_primary_10_1111_cmi_12619 crossref_primary_10_1128_microbiolspec_VMBF_0003_2014 crossref_primary_10_1371_journal_ppat_1002988 crossref_primary_10_3389_fcimb_2019_00065 crossref_primary_10_1016_j_vaccine_2012_01_023 crossref_primary_10_1016_j_tube_2016_09_019 crossref_primary_10_1126_science_1184429 crossref_primary_10_1128_IAI_00561_06 crossref_primary_10_4161_viru_22329 crossref_primary_10_1007_s12038_018_9775_0 crossref_primary_10_1021_pr300125t crossref_primary_10_1080_08830185_2021_1990277 crossref_primary_10_1128_AAC_00012_09 crossref_primary_10_1038_nrm1959 crossref_primary_10_1080_21645515_2021_1885280 crossref_primary_10_3389_fcimb_2020_582563 crossref_primary_10_1186_s12865_015_0102_3 crossref_primary_10_1111_imr_12252 crossref_primary_10_1073_pnas_0707206105 crossref_primary_10_1371_journal_ppat_1006551 crossref_primary_10_1111_j_1462_5822_2008_01239_x crossref_primary_10_1371_journal_pone_0077930 crossref_primary_10_1042_BST20221424 crossref_primary_10_1038_s41598_017_18528_y crossref_primary_10_1073_pnas_0607528103 crossref_primary_10_1111_cmi_12527 crossref_primary_10_1038_nrm2217 crossref_primary_10_1080_21505594_2017_1361089 crossref_primary_10_1111_j_1600_0854_2008_00804_x crossref_primary_10_1128_JB_06306_11 crossref_primary_10_3389_fimmu_2019_02874 crossref_primary_10_1016_j_bbalip_2020_158703 crossref_primary_10_1016_j_bbalip_2014_09_015 crossref_primary_10_1111_j_1600_065X_2007_00546_x crossref_primary_10_1016_j_bbalip_2014_09_011 crossref_primary_10_1099_mic_0_001041 crossref_primary_10_1146_annurev_pathol_011811_132458 crossref_primary_10_1093_femspd_ftab015 crossref_primary_10_1089_dna_2017_4066 crossref_primary_10_1111_j_1600_0854_2011_01165_x crossref_primary_10_1128_MMBR_00023_07 crossref_primary_10_1139_cjm_2014_0087 crossref_primary_10_1074_jbc_M700035200 crossref_primary_10_1371_journal_pone_0036198 crossref_primary_10_3389_fcell_2020_00439 crossref_primary_10_1074_jbc_M113_455915 crossref_primary_10_3389_fcimb_2023_1107884 crossref_primary_10_1371_journal_pone_0186505 crossref_primary_10_1016_j_micinf_2005_10_028 crossref_primary_10_1080_07352680500221054 crossref_primary_10_1128_microbiolspec_MGM2_0006_2013 crossref_primary_10_3390_microorganisms13010021 crossref_primary_10_3390_microorganisms9020414 crossref_primary_10_1073_pnas_2315481121 crossref_primary_10_1189_jlb_0510270 crossref_primary_10_1083_jcb_201105019 crossref_primary_10_1016_j_chom_2008_03_008 crossref_primary_10_1016_j_drudis_2012_03_012 crossref_primary_10_1242_jcs_006221 crossref_primary_10_15252_embr_202052175 crossref_primary_10_1016_j_pep_2020_105663 crossref_primary_10_1038_ni_1758 crossref_primary_10_1128_IAI_00257_09 crossref_primary_10_1016_j_chest_2017_04_170 crossref_primary_10_4236_ns_2013_56088 crossref_primary_10_3389_fcimb_2016_00079 crossref_primary_10_1016_j_chom_2010_06_002 crossref_primary_10_1038_srep13629 crossref_primary_10_1371_journal_ppat_1004471 crossref_primary_10_1007_s12013_012_9341_6 |
| Cites_doi | 10.1006/abio.2001.5179 10.1126/science.1088063 10.1083/jcb.200107069 10.1128/JB.182.19.5425-5432.2000 10.1074/jbc.275.2.992 10.1084/jem.191.2.287 10.1038/28879 10.1146/annurev.cellbio.20.010403.114015 10.1084/jem.20030527 10.1021/bi00450a008 10.1083/jcb.200106049 10.1091/mbc.e03-05-0307 10.1099/00221287-144-2-577 10.1083/jcb.143.6.1647 10.1128/JB.182.23.6850-6853.2000 10.1128/iai.65.11.4515-4524.1997 10.1083/jcb.200205034 10.1093/emboj/19.17.4577 10.1074/jbc.272.20.13326 10.1006/abio.2000.4497 10.1016/j.cell.2004.11.038 10.1002/j.1460-2075.1996.tb01088.x 10.1086/315676 10.1038/35083070 10.1016/S0960-9822(01)00501-2 10.1128/IAI.68.5.2671-2684.2000 10.1073/pnas.0737613100 10.1128/MCB.24.10.4593-4604.2004 10.1074/jbc.M405082200 10.1034/j.1600-0854.2004.00071.x 10.1084/jem.184.4.1349 10.1006/jmbi.2001.5072 10.1038/nrm1360 10.1126/science.8303277 10.1016/S0021-9258(18)49980-2 10.1016/S0955-0674(00)00195-2 10.1074/jbc.270.43.25709 10.1073/pnas.160255697 10.1083/jcb.130.4.781 10.1038/nrm973 |
| ContentType | Journal Article |
| Copyright | Copyright 1993/2005 The National Academy of Sciences of the United States of America Copyright National Academy of Sciences Mar 15, 2005 Copyright © 2005, The National Academy of Sciences 2005 |
| Copyright_xml | – notice: Copyright 1993/2005 The National Academy of Sciences of the United States of America – notice: Copyright National Academy of Sciences Mar 15, 2005 – notice: Copyright © 2005, The National Academy of Sciences 2005 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 5PM |
| DOI | 10.1073/pnas.0409716102 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts Ecology Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Entomology Abstracts Genetics Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts MEDLINE - Academic |
| DatabaseTitleList | Virology and AIDS Abstracts Bacteriology Abstracts (Microbiology B) MEDLINE MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 1091-6490 |
| EndPage | 4038 |
| ExternalDocumentID | PMC554822 819098071 15753315 10_1073_pnas_0409716102 102_11_4033 3374861 |
| Genre | Research Support, U.S. Gov't, P.H.S Journal Article Feature |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: AI45148 – fundername: NIAID NIH HHS grantid: R01 AI045148 – fundername: NIAID NIH HHS grantid: N01 AI-75320 |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29P 2AX 2FS 2WC 3O- 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE AAYJJ ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACHIC ACIWK ACNCT ACPRK ADQXQ ADULT ADXHL AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM AS~ BKOMP CS3 D0L DCCCD DIK DU5 E3Z EBS EJD F5P FRP GX1 H13 HH5 HQ3 HTVGU HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JST KQ8 L7B LU7 MVM N9A NEJ N~3 O9- OK1 P-O PNE PQQKQ R.V RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR VOH W8F WH7 WHG WOQ WOW X7M XSW Y6R YBH YKV YSK ZCA ZCG ~02 ~KM - 02 0R 1AW 55 AAPBV ABFLS ABPTK ADACO ADZLD AJYGW AS ASUFR DNJUQ DOOOF DWIUU DZ F20 GJ JSODD KM OHM PQEST RHF VQA X XFK XHC ZA5 AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7QR 7SN 7SS 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c526t-51a5dc0a3705f2fc38b0e55b14436735c0ca90acf7e422978aab07eedf3aa7893 |
| ISSN | 0027-8424 |
| IngestDate | Thu Aug 21 18:33:23 EDT 2025 Thu Jul 10 17:55:50 EDT 2025 Fri Jul 11 07:19:17 EDT 2025 Mon Jun 30 10:41:51 EDT 2025 Thu Apr 03 06:54:39 EDT 2025 Tue Jul 01 04:00:07 EDT 2025 Thu Apr 24 22:59:29 EDT 2025 Wed Nov 11 00:29:32 EST 2020 Thu May 30 08:53:55 EDT 2019 Thu May 29 08:40:57 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c526t-51a5dc0a3705f2fc38b0e55b14436735c0ca90acf7e422978aab07eedf3aa7893 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 I.V. and J.C. contributed equally to this work. To whom correspondence should be addressed. E-mail: vderetic@salud.unm.edu. This paper was submitted directly (Track II) to the PNAS office. Edited by R. John Collier, Harvard Medical School, Boston, MA, and approved January 26, 2005 Abbreviations: PI3K, phosphatidylinositol 3-kinase; PI3P, phosphatidylinositol 3-phosphate; 4D, four-dimensional; BCG, bacillus Calmette–Guérin; MtCFP, Mycobacterium tuberculosis H37Rv culture filtrate protein; RFU, relative fluorescence unit; MTM, myotubularin. Author contributions: I.V., J.C., J.B., and V.D. designed research; I.V., J.C., and H.-H.L. performed research; I.V., J.C., M.L., and J.B. contributed new reagents/analytic tools; I.V., J.C., H.-H.L., and V.D. analyzed data; J.C. planned and performed UltraView 4D microscopy and analyzed live microscopy data with GFP probes; I.V. planned and carried out Ca2+ imaging studies; J.C. and I.V. generated figures; J.C. generated movies; and V.D. edited figures and finalized the text and the paper. |
| OpenAccessLink | http://doi.org/10.1073/pnas.0409716102 |
| PMID | 15753315 |
| PQID | 201300690 |
| PQPubID | 42026 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_554822 pubmed_primary_15753315 crossref_citationtrail_10_1073_pnas_0409716102 proquest_miscellaneous_17276572 pnas_primary_102_11_4033 proquest_journals_201300690 jstor_primary_3374861 pnas_primary_102_11_4033_fulltext proquest_miscellaneous_67522810 crossref_primary_10_1073_pnas_0409716102 |
| ProviderPackageCode | RNA PNE CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2005-03-15 |
| PublicationDateYYYYMMDD | 2005-03-15 |
| PublicationDate_xml | – month: 03 year: 2005 text: 2005-03-15 day: 15 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Washington |
| PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
| PublicationTitleAlternate | Proc Natl Acad Sci U S A |
| PublicationYear | 2005 |
| Publisher | National Academy of Sciences National Acad Sciences |
| Publisher_xml | – name: National Academy of Sciences – name: National Acad Sciences |
| References | e_1_3_2_26_2 e_1_3_2_27_2 e_1_3_2_28_2 e_1_3_2_29_2 e_1_3_2_40_2 e_1_3_2_20_2 e_1_3_2_21_2 e_1_3_2_22_2 e_1_3_2_23_2 e_1_3_2_24_2 e_1_3_2_25_2 e_1_3_2_9_2 e_1_3_2_15_2 e_1_3_2_38_2 e_1_3_2_8_2 e_1_3_2_16_2 e_1_3_2_37_2 e_1_3_2_7_2 e_1_3_2_17_2 e_1_3_2_6_2 e_1_3_2_18_2 e_1_3_2_39_2 e_1_3_2_19_2 e_1_3_2_1_2 e_1_3_2_30_2 e_1_3_2_32_2 e_1_3_2_10_2 e_1_3_2_31_2 e_1_3_2_5_2 e_1_3_2_11_2 e_1_3_2_34_2 e_1_3_2_4_2 e_1_3_2_12_2 e_1_3_2_33_2 e_1_3_2_3_2 e_1_3_2_13_2 e_1_3_2_36_2 e_1_3_2_2_2 e_1_3_2_14_2 e_1_3_2_35_2 9697774 - Nature. 1998 Jul 30;394(6692):494-8 11489920 - J Cell Biol. 2001 Aug 6;154(3):631-44 2558716 - Biochemistry. 1989 Nov 28;28(24):9286-92 10970851 - EMBO J. 2000 Sep 1;19(17):4577-88 14576437 - Science. 2003 Oct 24;302(5645):654-9 9353028 - Infect Immun. 1997 Nov;65(11):4515-24 12461556 - Nat Rev Mol Cell Biol. 2002 Dec;3(12):893-905 15071556 - Nat Rev Mol Cell Biol. 2004 Apr;5(4):317-23 11433300 - Nat Cell Biol. 2001 Jul;3(7):675-8 14617817 - Mol Biol Cell. 2004 Feb;15(2):751-60 12702770 - Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5437-42 10900271 - Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5 7592750 - J Biol Chem. 1995 Oct 27;270(43):25709-14 15607973 - Cell. 2004 Dec 17;119(6):753-66 11676921 - Curr Biol. 2001 Oct 16;11(20):1600-5 15121875 - Mol Cell Biol. 2004 May;24(10):4593-604 7642697 - J Cell Biol. 1995 Aug;130(4):781-96 10637273 - J Exp Med. 2000 Jan 17;191(2):287-302 9493394 - Microbiology. 1998 Feb;144 ( Pt 2):577-87 11581283 - J Cell Biol. 2001 Oct 1;155(1):19-25 10706796 - Anal Biochem. 2000 Mar 15;279(2):248-50 10986245 - J Bacteriol. 2000 Oct;182(19):5425-32 1993697 - J Biol Chem. 1991 Feb 15;266(5):3239-45 10768959 - Infect Immun. 2000 May;68(5):2671-84 12925680 - J Exp Med. 2003 Aug 18;198(4):653-9 15473845 - Annu Rev Cell Dev Biol. 2004;20:367-94 9148954 - J Biol Chem. 1997 May 16;272(20):13326-31 9852157 - J Cell Biol. 1998 Dec 14;143(6):1647-59 11476556 - Anal Biochem. 2001 Aug 1;295(1):122-6 8303277 - Science. 1994 Feb 4;263(5147):678-81 12147678 - J Cell Biol. 2002 Aug 5;158(3):421-6 11073936 - J Bacteriol. 2000 Dec;182(23):6850-3 15210698 - J Biol Chem. 2004 Aug 27;279(35):36982-92 11248551 - Curr Opin Cell Biol. 2001 Apr;13(2):172-81 10882603 - J Infect Dis. 2000 Jul;182(1):240-51 12694559 - Traffic. 2003 Apr;4(4):201-13 10625637 - J Biol Chem. 2000 Jan 14;275(2):992-8 9003772 - EMBO J. 1996 Dec 16;15(24):6960-8 11697911 - J Mol Biol. 2001 Nov 2;313(4):889-901 8879207 - J Exp Med. 1996 Oct 1;184(4):1349-55 |
| References_xml | – ident: e_1_3_2_27_2 doi: 10.1006/abio.2001.5179 – ident: e_1_3_2_9_2 doi: 10.1126/science.1088063 – ident: e_1_3_2_16_2 doi: 10.1083/jcb.200107069 – ident: e_1_3_2_31_2 doi: 10.1128/JB.182.19.5425-5432.2000 – ident: e_1_3_2_22_2 doi: 10.1074/jbc.275.2.992 – ident: e_1_3_2_26_2 doi: 10.1084/jem.191.2.287 – ident: e_1_3_2_17_2 doi: 10.1038/28879 – ident: e_1_3_2_2_2 doi: 10.1146/annurev.cellbio.20.010403.114015 – ident: e_1_3_2_24_2 doi: 10.1084/jem.20030527 – ident: e_1_3_2_40_2 doi: 10.1021/bi00450a008 – ident: e_1_3_2_11_2 doi: 10.1083/jcb.200106049 – ident: e_1_3_2_5_2 doi: 10.1091/mbc.e03-05-0307 – ident: e_1_3_2_38_2 doi: 10.1099/00221287-144-2-577 – ident: e_1_3_2_18_2 doi: 10.1083/jcb.143.6.1647 – ident: e_1_3_2_30_2 doi: 10.1128/JB.182.23.6850-6853.2000 – ident: e_1_3_2_29_2 doi: 10.1128/iai.65.11.4515-4524.1997 – ident: e_1_3_2_1_2 doi: 10.1083/jcb.200205034 – ident: e_1_3_2_32_2 doi: 10.1093/emboj/19.17.4577 – ident: e_1_3_2_7_2 doi: 10.1074/jbc.272.20.13326 – ident: e_1_3_2_28_2 doi: 10.1006/abio.2000.4497 – ident: e_1_3_2_23_2 doi: 10.1016/j.cell.2004.11.038 – ident: e_1_3_2_4_2 doi: 10.1002/j.1460-2075.1996.tb01088.x – ident: e_1_3_2_25_2 doi: 10.1086/315676 – ident: e_1_3_2_21_2 doi: 10.1038/35083070 – ident: e_1_3_2_36_2 doi: 10.1016/S0960-9822(01)00501-2 – ident: e_1_3_2_8_2 doi: 10.1128/IAI.68.5.2671-2684.2000 – ident: e_1_3_2_12_2 doi: 10.1073/pnas.0737613100 – ident: e_1_3_2_13_2 doi: 10.1128/MCB.24.10.4593-4604.2004 – ident: e_1_3_2_14_2 doi: 10.1074/jbc.M405082200 – ident: e_1_3_2_15_2 doi: 10.1034/j.1600-0854.2004.00071.x – ident: e_1_3_2_6_2 doi: 10.1084/jem.184.4.1349 – ident: e_1_3_2_10_2 doi: 10.1006/jmbi.2001.5072 – ident: e_1_3_2_19_2 doi: 10.1038/nrm1360 – ident: e_1_3_2_3_2 doi: 10.1126/science.8303277 – ident: e_1_3_2_33_2 doi: 10.1016/S0021-9258(18)49980-2 – ident: e_1_3_2_37_2 doi: 10.1016/S0955-0674(00)00195-2 – ident: e_1_3_2_39_2 doi: 10.1074/jbc.270.43.25709 – ident: e_1_3_2_35_2 doi: 10.1073/pnas.160255697 – ident: e_1_3_2_34_2 doi: 10.1083/jcb.130.4.781 – ident: e_1_3_2_20_2 doi: 10.1038/nrm973 – reference: 10882603 - J Infect Dis. 2000 Jul;182(1):240-51 – reference: 11476556 - Anal Biochem. 2001 Aug 1;295(1):122-6 – reference: 14576437 - Science. 2003 Oct 24;302(5645):654-9 – reference: 15473845 - Annu Rev Cell Dev Biol. 2004;20:367-94 – reference: 11676921 - Curr Biol. 2001 Oct 16;11(20):1600-5 – reference: 9493394 - Microbiology. 1998 Feb;144 ( Pt 2):577-87 – reference: 10970851 - EMBO J. 2000 Sep 1;19(17):4577-88 – reference: 12694559 - Traffic. 2003 Apr;4(4):201-13 – reference: 9852157 - J Cell Biol. 1998 Dec 14;143(6):1647-59 – reference: 7642697 - J Cell Biol. 1995 Aug;130(4):781-96 – reference: 11073936 - J Bacteriol. 2000 Dec;182(23):6850-3 – reference: 15121875 - Mol Cell Biol. 2004 May;24(10):4593-604 – reference: 9353028 - Infect Immun. 1997 Nov;65(11):4515-24 – reference: 10637273 - J Exp Med. 2000 Jan 17;191(2):287-302 – reference: 14617817 - Mol Biol Cell. 2004 Feb;15(2):751-60 – reference: 7592750 - J Biol Chem. 1995 Oct 27;270(43):25709-14 – reference: 11248551 - Curr Opin Cell Biol. 2001 Apr;13(2):172-81 – reference: 10900271 - Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5 – reference: 11581283 - J Cell Biol. 2001 Oct 1;155(1):19-25 – reference: 9697774 - Nature. 1998 Jul 30;394(6692):494-8 – reference: 10706796 - Anal Biochem. 2000 Mar 15;279(2):248-50 – reference: 12461556 - Nat Rev Mol Cell Biol. 2002 Dec;3(12):893-905 – reference: 11697911 - J Mol Biol. 2001 Nov 2;313(4):889-901 – reference: 12702770 - Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5437-42 – reference: 1993697 - J Biol Chem. 1991 Feb 15;266(5):3239-45 – reference: 9003772 - EMBO J. 1996 Dec 16;15(24):6960-8 – reference: 9148954 - J Biol Chem. 1997 May 16;272(20):13326-31 – reference: 2558716 - Biochemistry. 1989 Nov 28;28(24):9286-92 – reference: 15071556 - Nat Rev Mol Cell Biol. 2004 Apr;5(4):317-23 – reference: 10625637 - J Biol Chem. 2000 Jan 14;275(2):992-8 – reference: 10768959 - Infect Immun. 2000 May;68(5):2671-84 – reference: 8303277 - Science. 1994 Feb 4;263(5147):678-81 – reference: 11433300 - Nat Cell Biol. 2001 Jul;3(7):675-8 – reference: 11489920 - J Cell Biol. 2001 Aug 6;154(3):631-44 – reference: 12147678 - J Cell Biol. 2002 Aug 5;158(3):421-6 – reference: 12925680 - J Exp Med. 2003 Aug 18;198(4):653-9 – reference: 8879207 - J Exp Med. 1996 Oct 1;184(4):1349-55 – reference: 15210698 - J Biol Chem. 2004 Aug 27;279(35):36982-92 – reference: 15607973 - Cell. 2004 Dec 17;119(6):753-66 – reference: 10986245 - J Bacteriol. 2000 Oct;182(19):5425-32 |
| SSID | ssj0009580 |
| Score | 2.3693304 |
| Snippet | Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in... Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with phagolysosome biogenesis. Here, using four-dimensional microscopy and in... |
| SourceID | pubmedcentral proquest pubmed crossref pnas jstor |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 4033 |
| SubjectTerms | Animals Biological Sciences Calcium - metabolism Cellular biology Endosomes Fluorescence Lipids Macrophages Macrophages - microbiology Macrophages - physiology Mice Microscopy Molybdates Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity Mycobacterium tuberculosis - physiology Phagosomes Phagosomes - physiology Phosphatases Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Phosphates - metabolism Phosphatidylinositols Scientific imaging Tuberculosis |
| Title | Mechanism of Phagolysosome Biogenesis Block by Viable Mycobacterium tuberculosis |
| URI | https://www.jstor.org/stable/3374861 http://www.pnas.org/content/102/11/4033.abstract https://www.ncbi.nlm.nih.gov/pubmed/15753315 https://www.proquest.com/docview/201300690 https://www.proquest.com/docview/17276572 https://www.proquest.com/docview/67522810 https://pubmed.ncbi.nlm.nih.gov/PMC554822 |
| Volume | 102 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELbKeOEFMRgsjB9B4mGoykjsJE4fpwlUkFr1YUN7ixzHaSvaZGoaUPnrOTuOk5RVAl6iynZcK_f5cufcfYfQ-xCnlGW-63AmUsdPSOiMfM9zRMoZuCvYS4U875hMw_GN__U2uB0Mqm52yTa54L_uzSv5H6lCG8hVZsn-g2TNpNAAv0G-cAUJw_WvZDwRMm9XlrmQccsLNi9Wu7Ioi7UYJstiLtXYspSx6fy7NDN_LFWe1GTHYRMrkuZqPdxWidjwalWUy7Jrqc7Mm61s4gimzcHhZZuGonVDOXSGs2lb1Pib2Mzrs9IvJZPfNgx-rhYV64bV7EUEjX-yfO6MC9Msi7KpU1sx10BuzigCGaRVZ2manAF4F_p1trTRuy7uAszrqFHfrdkx_tDvoJBkUeKclReur-iv9Cwdad-tlbg9MEQJ0avoU2o3XQ_QQwzeBVb6vMvVHNWZS3rRDSMUJR_3_lkVdarn6tk1dWir5MuF8ff5LvshuB2b5voJeqydEfuyRtYxGoj8KTpuRGqfa07yD8_QzEDNLjK7BzW7hZqtoGYnO7uGmt2Dmt2F2gm6-fzp-mrs6GIcDg9wuHUCjwUpdxmhbpDhjJMocUUQJOCQk5CSgLucjVzGMyp8jEc0YixxKeA0I4xRsIqfo6O8yMUpsn1JSSRGJEvBNqSZn0R85CUpzVIwqLxIWOiieZQx10z1smDKKlYRE5TE8rHGrRgsdG5uuKtJWg4PPVGyMeOI5F8KPQudqpHt7Ric41gC0ULvDnXFmY7QstBZI-NYK4gyxjIqQDKBW-it6QXtLT_JsVwUVRlL9yEMKD48Ahx6jCMP5nhRI6Zdh0aehcIelswAyRzf78mXC8UgDz4EOAYvD055hh612_gVOtpuKvEajO9t8kZtld_3-dkr |
| linkProvider | ABC ChemistRy |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mechanism+of+phagolysosome+biogenesis+block+by+viable+Mycobacterium+tuberculosis&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Vergne%2C+Isabelle&rft.au=Chua%2C+Jennifer&rft.au=Lee%2C+Hwang-Ho&rft.au=Lucas%2C+Megan&rft.date=2005-03-15&rft.issn=0027-8424&rft.volume=102&rft.issue=11&rft.spage=4033&rft_id=info:doi/10.1073%2Fpnas.0409716102&rft_id=info%3Apmid%2F15753315&rft.externalDocID=15753315 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F102%2F11.cover.gif |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F102%2F11.cover.gif |