Association among Polymorphisms in EGFR Gene Exons, Lifestyle and Risk of Gastric Cancer with Gender Differences in Chinese Han Subjects

• Published in: PloS one Vol. 8; no. 3; p. e59254
• Main Authors: Zhang, Junfeng, Zhan, Zhen, Wu, Juan, Zhang, Chunbing, Yang, Yaping, Tong, Shujuan, Sun, Zheng, Qin, Lei, Yang, Xuewen, Dong, Wei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.03.2013; Public Library of Science (PLoS)
• Subjects: Adenocarcinoma - ethnology; Adenocarcinoma - etiology; Adenocarcinoma - genetics; Age; Aged; Alcohol; Alcohol Drinking - adverse effects; Alleles; Angiogenesis; Asian Continental Ancestry Group; Biology; Cancer; Case-Control Studies; Chinese medicine; Discipline; Epidermal growth factor; Epidermal growth factor receptors; Exons; Female; Females; Food preferences; Gastric cancer; Gender aspects; Gender differences; Gene amplification; Gene Frequency; Genetic diversity; Genetic Predisposition to Disease; Genetic variance; Genotypes; Haplotypes; Health risks; Hospitals; Humans; Kinases; Laboratories; Life Style; Lung cancer; Male; Males; Medical prognosis; Medicine; Metastases; Middle Aged; Mortality; Mutation; Polymorphism, Single Nucleotide; Population; Receptor, Epidermal Growth Factor - genetics; Risk; Risk Factors; Sex differences; Single-nucleotide polymorphism; Smoking; Smoking - adverse effects; Sodium Chloride, Dietary - adverse effects; Stomach cancer; Stomach Neoplasms - ethnology; Stomach Neoplasms - etiology; Stomach Neoplasms - genetics; Studies; Traditional Chinese medicine; Tumors; China

The epidermal growth factor receptor (EGFR) gene plays a key role in tumor survival, invasion, angiogenesis, and metastatic spread. Recent studies showed that gastric cancer (GC) was associated with polymorphisms of the EGFR gene and environmental influences, such as lifestyle factors. In this study...