Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients

• Published in: Brain (London, England : 1878) Vol. 133; no. 11; pp. 3232 - 3242
• Main Authors: Vagnozzi, Roberto, Signoretti, Stefano, Cristofori, Luciano, Alessandrini, Franco, Floris, Roberto, Isgrò, Eugenio, Ria, Antonio, Marziale, Simone, Zoccatelli, Giada, Tavazzi, Barbara, Del Bolgia, Franco, Sorge, Roberto, Broglio, Steven P., McIntosh, Tracy K., Lazzarino, Giuseppe
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2010
• Subjects: 1H-magnetic resonance spectroscopy; Adolescent; Adult; Biological and medical sciences; Brain Concussion - diagnosis; Brain Concussion - metabolism; Brain Concussion - physiopathology; Brain Diseases, Metabolic - diagnosis; Brain Diseases, Metabolic - metabolism; Brain Diseases, Metabolic - physiopathology; Brain Injuries - diagnosis; Brain Injuries - metabolism; Brain Injuries - physiopathology; Cohort Studies; Female; Humans; Injuries of the nervous system and the skull. Diseases due to physical agents; Magnetic Resonance Spectroscopy; Male; Medical sciences; metabolic brain vulnerability; mild traumatic brain injury; N-acetylaspartate; Neurology; Protons; Recovery of Function - physiology; sport-related concussion; Time Factors; Traumas. Diseases due to physical agents; Young Adult; Human; Nervous system diseases; Central nervous system; sport-related concussion; Contusion; NMR spectrometry; Vulnerability; H-magnetic resonance spectroscopy; Recovery; mild traumatic brain injury; N-acetylaspartate; Encephalon; Cerebral disorder; Sport; Central nervous system disease; Proton; Head trauma; metabolic brain vulnerability

Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact synd...