Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients
Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact synd...
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| Published in | Brain (London, England : 1878) Vol. 133; no. 11; pp. 3232 - 3242 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Oxford University Press
01.11.2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-8950 1460-2156 1460-2156 |
| DOI | 10.1093/brain/awq200 |
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| Abstract | Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16–35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: −17.6%, N-acetylaspartate/choline: −21.4%; P < 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. |
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| AbstractList | Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16-35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: -17.6%, N-acetylaspartate/choline: -21.4%; P < 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed.Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16-35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: -17.6%, N-acetylaspartate/choline: -21.4%; P < 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16–35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: −17.6%, N-acetylaspartate/choline: −21.4%; P < 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0 T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16-35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: -17.6%, N-acetylaspartate/choline: -21.4%; P < 0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. Concussive head injury opens a temporary window of brain vulnerability due to the impairment of cellular energetic metabolism. As experimentally demonstrated, a second mild injury occurring during this period can lead to severe brain damage, a condition clinically described as the second impact syndrome. To corroborate the validity of proton magnetic resonance spectroscopy in monitoring cerebral metabolic changes following mild traumatic brain injury, apart from the magnetic field strength (1.5 or 3.0T) and mode of acquisition, we undertook a multicentre prospective study in which a cohort of 40 athletes suffering from concussion and a group of 30 control healthy subjects were admitted. Athletes (aged 16-35 years) were recruited and examined at three different institutions between September 2007 and June 2009. They underwent assessment of brain metabolism at 3, 15, 22 and 30 days post-injury through proton magnetic resonance spectroscopy for the determination of N-acetylaspartate, creatine and choline-containing compounds. Values of these representative brain metabolites were compared with those observed in the group of non-injured controls. Comparison of spectroscopic data, obtained in controls using different field strength and/or mode of acquisition, did not show any difference in the brain metabolite ratios. Athletes with concussion exhibited the most significant alteration of metabolite ratios at Day 3 post-injury (N-acetylaspartate/creatine: -17.6%, N-acetylaspartate/choline: -21.4%; P<0.001 with respect to controls). On average, metabolic disturbance gradually recovered, initially in a slow fashion and, following Day 15, more rapidly. At 30 days post-injury, all athletes showed complete recovery, having metabolite ratios returned to values detected in controls. Athletes self-declared symptom clearance between 3 and 15 days after concussion. Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury. In particular, this metabolic evaluation may significantly improve, along with other clinical assessments, the management of athletes suffering from concussion. Further studies to verify the effects of a second concussive event occurring at different time points of the recovery curve of brain metabolism are needed. |
| Author | Marziale, Simone Broglio, Steven P. Isgrò, Eugenio Vagnozzi, Roberto Lazzarino, Giuseppe Floris, Roberto Alessandrini, Franco Zoccatelli, Giada Del Bolgia, Franco Sorge, Roberto McIntosh, Tracy K. Signoretti, Stefano Tavazzi, Barbara Cristofori, Luciano Ria, Antonio |
| Author_xml | – sequence: 1 givenname: Roberto surname: Vagnozzi fullname: Vagnozzi, Roberto organization: 1 Department of Neurosciences, University of Rome ‘Tor Vergata’, 00133 Rome, Italy – sequence: 2 givenname: Stefano surname: Signoretti fullname: Signoretti, Stefano organization: 2 Department of Head and Neck Surgery, Division of Neurosugery, S. Camillo Hospital, 00152 Rome, Italy – sequence: 3 givenname: Luciano surname: Cristofori fullname: Cristofori, Luciano organization: 3 Department of Neurosurgery, Ospedale Maggiore di Verona ‘Borgo Trento’, 37126 Verona, Italy – sequence: 4 givenname: Franco surname: Alessandrini fullname: Alessandrini, Franco organization: 4 Service of Neuroradiology, Ospedale Maggiore di Verona ‘Borgo Trento’, 37126 Verona, Italy – sequence: 5 givenname: Roberto surname: Floris fullname: Floris, Roberto organization: 5 Department of Diagnostic Imaging and Interventional Radiology, University of Rome ‘Tor Vergata’, 00133 Rome, Italy – sequence: 6 givenname: Eugenio surname: Isgrò fullname: Isgrò, Eugenio organization: 6 Department of Neurosciences, Division of Neuroradiology, University of Parma, 43126 Parma, Italy – sequence: 7 givenname: Antonio surname: Ria fullname: Ria, Antonio organization: 3 Department of Neurosurgery, Ospedale Maggiore di Verona ‘Borgo Trento’, 37126 Verona, Italy – sequence: 8 givenname: Simone surname: Marziale fullname: Marziale, Simone organization: 5 Department of Diagnostic Imaging and Interventional Radiology, University of Rome ‘Tor Vergata’, 00133 Rome, Italy – sequence: 9 givenname: Giada surname: Zoccatelli fullname: Zoccatelli, Giada organization: 4 Service of Neuroradiology, Ospedale Maggiore di Verona ‘Borgo Trento’, 37126 Verona, Italy – sequence: 10 givenname: Barbara surname: Tavazzi fullname: Tavazzi, Barbara organization: 7 Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, 00168 Rome, Italy – sequence: 11 givenname: Franco surname: Del Bolgia fullname: Del Bolgia, Franco organization: 1 Department of Neurosciences, University of Rome ‘Tor Vergata’, 00133 Rome, Italy – sequence: 12 givenname: Roberto surname: Sorge fullname: Sorge, Roberto organization: 1 Department of Neurosciences, University of Rome ‘Tor Vergata’, 00133 Rome, Italy – sequence: 13 givenname: Steven P. surname: Broglio fullname: Broglio, Steven P. organization: 8 Neurotrauma Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA – sequence: 14 givenname: Tracy K. surname: McIntosh fullname: McIntosh, Tracy K. organization: 9 Media NeuroConsultants Inc., Media, PA 19063, USA – sequence: 15 givenname: Giuseppe surname: Lazzarino fullname: Lazzarino, Giuseppe email: lazzarig@unict.it organization: 10 Department of Chemical Sciences, Division of Biochemistry and Molecular Biology, University of Catania, 95125 Catania, Italy |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23416275$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20736189$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0169-328X(95)00044-S 10.1016/j.jemermed.2005.01.020 10.1080/02699050500309817 10.1227/01.NEU.0000255430.62291.7B 10.1016/j.sleep.2007.11.023 10.3174/ajnr.A0774 10.1016/0006-8993(92)91205-S 10.1007/s11010-009-0228-9 10.1093/arclin/acp025 10.1227/01.NEU.0000156715.04900.E6 10.1046/j.1471-4159.2001.t01-1-00282.x 10.1007/s00701-005-0651-y 10.1227/01.NEU.0000163413.90259.85 10.1001/jama.290.19.2549 10.3171/jns.1994.80.2.0291 10.1136/bjsm.2005.021683 10.1227/01.NEU.0000255525.34956.3F 10.1097/01.jsm.0000186683.59158.8b 10.1016/j.acn.2005.08.001 10.1249/00149619-200212000-00004 10.1227/01.NEU.0000255479.90999.C0 10.1089/neu.2009.0896 10.1227/01.NEU.0000137657.00146.7D 10.1023/A:1013733107520 10.1002/cne.20080 10.1542/peds.2008-0309 10.3171/jns.2007.106.3.370 10.1046/j.1471-4159.2003.01905.x 10.1097/01.wco.0000186840.61431.44 10.1227/01.NEU.0000280002.41696.D8 10.1136/bjsm.2009.058248 10.1016/0006-8993(89)91409-1 10.1016/j.csm.2009.09.002 10.1007/s00234-006-0109-9 10.1016/j.csm.2004.04.001 10.1159/000094169 10.1001/jama.290.19.2556 10.3171/JNS/2008/108/01/0042 10.1097/00042752-200401000-00003 10.1016/j.pneurobio.2006.12.003 10.1001/jama.1984.03350040068030 10.1046/j.0022-3042.2002.00777.x 10.1023/A:1023250721185 10.1227/01.NEU.0000149008.73513.44 10.1089/08977150152693683 10.1097/01.WCB.0000040581.43808.03 10.1111/j.1526-4610.2009.01494.x 10.1089/neu.2009.0962 10.1385/JMN:21:3:185 10.1227/01.NEU.0000335073.39728.CE 10.1089/neu.2000.17.389 10.1016/j.jocn.2009.02.002 10.1227/01.NEU.0000316421.58568.AD 10.1089/neu.1999.16.903 10.3171/jns.1994.80.2.0301 10.1016/S0278-5919(02)00095-9 |
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| Keywords | Human Nervous system diseases Central nervous system sport-related concussion Contusion NMR spectrometry Vulnerability H-magnetic resonance spectroscopy Recovery mild traumatic brain injury N-acetylaspartate Encephalon Cerebral disorder Sport Central nervous system disease Proton Head trauma metabolic brain vulnerability |
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| References | Giza (17_19165171) 2001; 36 Kurca (28_22582916) 2006; 48 Baslow (4_17603949) 2003; 28 Sinson (59_11020835) 2001; 22 Lifshitz (29_17493042) 2003; 23 Tagliaferri (60_21697665) 2006; 148 Hunt (24_36086620) 2010; 29 Vagnozzi (64_18959085) 2005; 57 Nakabayashi (44_27948156) 2007; 106 Broglio (7_28805522) 2007; 60 Henry (21_35619192) 2010; 27 Register-Mihalik (49_31791974) 2008; 63 Guskiewicz (19_17913610) 2003; 290 Pellman (45_18936648) 2004; 55 Foda (14_14666430) 1994; 80 Vagnozzi (66_32062243) 2008; 62 Gasparovic (15_34561120) 2009; 26 Vagnozzi (63_6351668) 1999; 16 (48_35101812) 2009; 24 Longhi (30_18695846) 2005; 56 (11_38406964) 2009; 43 (Suppl 1) Marmarou (34_14666429) 1994; 80 Sarmento (52_35455498) 2009; 49 Bergsneider (6_10332914) 2000; 17 Mehta (41_16089562) 1995; 31 Madhavarao (33_18122167) 2004; 472 Madhavarao (32_17743810) 2003; 86 Baslow (3_17932978) 2003; 21 McCrory (39_34742851) 2009; 16 Robertson (51_22563288) 2006; 28 Delaney (12_19271163) 2005; 29 Cantu (8_17713846) 2003; 22 Tavazzi (61_18904435) 2005; 56 Pratico (47_17002354) 2002; 80 McClincy (35_21503330) 2006; 20 McCrory (38_34809513) 2009; 43 (50_29553176) 2007; 28 Cohen (10_28509120) 2007; 28 McCrea (37_17987093) 2004; 14 Andersen (1_9946484) 1992; 585 Saunders (53_13251265) 1984; 252 Barth (2_19165167) 2001; 36 Kissick (27_19580236) 2005; 15 Moffett (42_23698576) 2007; 81 Signoretti (58_35444369) 2010; 333 Benedetti (5_23453382) 2007; 28 Gosselin (18_33417610) 2009; 10 Vagnozzi (65_29340808) 2007; 61 Engberg Aa (13_16924255) 2001; 17 Cantu (9_28806976) 2007; 60 Schleimer (55_18341446) 2002; 1 Lovell (31_18265677) 2004; 23 Ponsford (46_19583623) 2005; 18 Guskiewicz (20_21129138) 2006; 40 (54_33013823) 2006; 21 Signoretti (57_30225768) 2008; 108 Wurm (62_32019527) 2007; 61 Meehan (40_32957187) 2009; 123 McCrea (36_17913611) 2003; 290 Moreno (43_11091839) 2001; 77 Jenkins (26_5202248) 1989; 477 Signoretti (56_11380540) 2001; 18 Brain. 2013 Nov;136(Pt 11):i1 |
| References_xml | – volume: 31 start-page: 151 issn: 0169-328X issue: 1-2 year: 1995 ident: 41_16089562 publication-title: Brain research. Molecular brain research doi: 10.1016/0169-328X(95)00044-S – volume: 29 start-page: 189 issn: 0736-4679 issue: 2 year: 2005 ident: 12_19271163 publication-title: The Journal of emergency medicine doi: 10.1016/j.jemermed.2005.01.020 – volume: 20 start-page: 33 issn: 0269-9052 issue: 1 year: 2006 ident: 35_21503330 publication-title: Brain injury : [BI] doi: 10.1080/02699050500309817 – volume: 60 start-page: 963 issn: 0148-396X issue: 6 year: 2007 ident: 9_28806976 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000255430.62291.7B – volume: 10 start-page: 35 issn: 1389-9457 issue: 1 year: 2009 ident: 18_33417610 publication-title: Sleep medicine doi: 10.1016/j.sleep.2007.11.023 – volume: 28 start-page: 907 issn: 0195-6108 issue: 5 year: 2007 ident: 10_28509120 publication-title: American Journal of Neuroradiology – volume: 28 start-page: 1843 issn: 0195-6108 issue: 10 year: 2007 ident: 50_29553176 publication-title: American Journal of Neuroradiology doi: 10.3174/ajnr.A0774 – volume: 585 start-page: 184 issn: 0006-8993 issue: 1-2 year: 1992 ident: 1_9946484 publication-title: Brain research doi: 10.1016/0006-8993(92)91205-S – volume: 333 start-page: 269 issn: 0300-8177 issue: 1-2 year: 2010 ident: 58_35444369 publication-title: Molecular and cellular biochemistry doi: 10.1007/s11010-009-0228-9 – volume: 24 start-page: 219 issn: 0887-6177 issue: 3 year: 2009 ident: 48_35101812 publication-title: Archives of Clinical Neuropsychology doi: 10.1093/arclin/acp025 – volume: 56 start-page: 582 issn: 0148-396X issue: 3 year: 2005 ident: 61_18904435 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000156715.04900.E6 – volume: 77 start-page: 347 issn: 0022-3042 issue: 1 year: 2001 ident: 43_11091839 publication-title: Journal of neurochemistry doi: 10.1046/j.1471-4159.2001.t01-1-00282.x – volume: 148 start-page: 255 issn: 0001-6268 issue: 3 year: 2006 ident: 60_21697665 publication-title: Acta neurochirurgica doi: 10.1007/s00701-005-0651-y – volume: 57 start-page: 164 issn: 0148-396X issue: 1 year: 2005 ident: 64_18959085 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000163413.90259.85 – volume: 290 start-page: 2549 issn: 0098-7484 issue: 19 year: 2003 ident: 19_17913610 publication-title: JAMA doi: 10.1001/jama.290.19.2549 – volume: 80 start-page: 291 issn: 0022-3085 issue: 2 year: 1994 ident: 34_14666429 publication-title: Journal of neurosurgery doi: 10.3171/jns.1994.80.2.0291 – volume: 40 start-page: 6 issn: 0306-3674 issue: 1 year: 2006 ident: 20_21129138 publication-title: British Journal of Sports Medicine doi: 10.1136/bjsm.2005.021683 – volume: 61 start-page: 390 issn: 0148-396X issue: 1 Suppl year: 2007 ident: 62_32019527 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000255525.34956.3F – volume: 15 start-page: 426 issn: 1050-642X issue: 6 year: 2005 ident: 27_19580236 publication-title: Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine doi: 10.1097/01.jsm.0000186683.59158.8b – volume: 21 start-page: 91 issn: 0887-6177 issue: 1 year: 2006 ident: 54_33013823 publication-title: Archives of Clinical Neuropsychology doi: 10.1016/j.acn.2005.08.001 – volume: 1 start-page: 323 issn: 1537-890X issue: 6 year: 2002 ident: 55_18341446 publication-title: Current sports medicine reports doi: 10.1249/00149619-200212000-00004 – volume: 60 start-page: 1050 issn: 0148-396X issue: 6 year: 2007 ident: 7_28805522 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000255479.90999.C0 – volume: 26 start-page: 1635 issn: 0897-7151 issue: 10 year: 2009 ident: 15_34561120 publication-title: Journal of neurotrauma doi: 10.1089/neu.2009.0896 – volume: 55 start-page: 860 issn: 0148-396X issue: 4 year: 2004 ident: 45_18936648 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000137657.00146.7D – volume: 22 start-page: 143 issn: 0195-6108 issue: 1 year: 2001 ident: 59_11020835 publication-title: American Journal of Neuroradiology – volume: 36 start-page: 253 issn: 1062-6050 issue: 3 year: 2001 ident: 2_19165167 – volume: 17 start-page: 437 issn: 0393-2990 issue: 5 year: 2001 ident: 13_16924255 publication-title: European journal of epidemiology doi: 10.1023/A:1013733107520 – volume: 472 start-page: 318 issn: 0021-9967 issue: 3 year: 2004 ident: 33_18122167 publication-title: The Journal of comparative neurology doi: 10.1002/cne.20080 – volume: 123 start-page: 114 issn: 0031-4005 issue: 1 year: 2009 ident: 40_32957187 publication-title: Pediatrics doi: 10.1542/peds.2008-0309 – volume: 106 start-page: 370 issn: 0022-3085 issue: 3 year: 2007 ident: 44_27948156 publication-title: Journal of neurosurgery doi: 10.3171/jns.2007.106.3.370 – volume: 86 start-page: 824 issn: 0022-3042 issue: 4 year: 2003 ident: 32_17743810 publication-title: Journal of neurochemistry doi: 10.1046/j.1471-4159.2003.01905.x – volume: 18 start-page: 692 issn: 1350-7540 issue: 6 year: 2005 ident: 46_19583623 publication-title: Current opinion in neurology doi: 10.1097/01.wco.0000186840.61431.44 – volume: 61 start-page: 379 issn: 0148-396X issue: 5 Suppl 2 year: 2007 ident: 65_29340808 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000280002.41696.D8 – volume: 43 start-page: i76 issn: 0306-3674 issue: Suppl_1 year: 2009 ident: 38_34809513 publication-title: British Journal of Sports Medicine doi: 10.1136/bjsm.2009.058248 – volume: 477 start-page: 211 issn: 0006-8993 issue: 1-2 year: 1989 ident: 26_5202248 publication-title: Brain research doi: 10.1016/0006-8993(89)91409-1 – volume: 29 start-page: 5 issn: 0278-5919 issue: 1 year: 2010 ident: 24_36086620 publication-title: Clinics in sports medicine doi: 10.1016/j.csm.2009.09.002 – volume: 48 start-page: 661 issn: 0028-3940 issue: 9 year: 2006 ident: 28_22582916 publication-title: Neuroradiology doi: 10.1007/s00234-006-0109-9 – volume: 23 start-page: 421 issn: 0278-5919 issue: 3 year: 2004 ident: 31_18265677 publication-title: Clinics in sports medicine doi: 10.1016/j.csm.2004.04.001 – volume: 28 start-page: 432 issn: 0378-5866 issue: 4-5 year: 2006 ident: 51_22563288 publication-title: Developmental neuroscience doi: 10.1159/000094169 – volume: 290 start-page: 2556 issn: 0098-7484 issue: 19 year: 2003 ident: 36_17913611 publication-title: JAMA doi: 10.1001/jama.290.19.2556 – volume: 108 start-page: 42 issn: 0022-3085 issue: 1 year: 2008 ident: 57_30225768 publication-title: Journal of neurosurgery doi: 10.3171/JNS/2008/108/01/0042 – volume: 14 start-page: 13 issn: 1050-642X issue: 1 year: 2004 ident: 37_17987093 publication-title: Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine doi: 10.1097/00042752-200401000-00003 – volume: 81 start-page: 89 issn: 0301-0082 issue: 2 year: 2007 ident: 42_23698576 publication-title: Progress in neurobiology doi: 10.1016/j.pneurobio.2006.12.003 – volume: 252 start-page: 538 issn: 0098-7484 issue: 4 year: 1984 ident: 53_13251265 publication-title: JAMA doi: 10.1001/jama.1984.03350040068030 – volume: 80 start-page: 894 issn: 0022-3042 issue: 5 year: 2002 ident: 47_17002354 publication-title: Journal of neurochemistry doi: 10.1046/j.0022-3042.2002.00777.x – volume: 28 start-page: 941 issn: 0364-3190 issue: 6 year: 2003 ident: 4_17603949 publication-title: Neurochemical research doi: 10.1023/A:1023250721185 – volume: 56 start-page: 364 issn: 0148-396X issue: 2 year: 2005 ident: 30_18695846 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000149008.73513.44 – volume: 18 start-page: 977 issn: 0897-7151 issue: 10 year: 2001 ident: 56_11380540 publication-title: Journal of neurotrauma doi: 10.1089/08977150152693683 – volume: 23 start-page: 219 issn: 0271-678X issue: 2 year: 2003 ident: 29_17493042 publication-title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism doi: 10.1097/01.WCB.0000040581.43808.03 – volume: 49 start-page: 1345 issn: 0017-8748 issue: 9 year: 2009 ident: 52_35455498 publication-title: Headache doi: 10.1111/j.1526-4610.2009.01494.x – volume: 43 (Suppl 1) start-page: i36 issn: 0306-3674 year: 2009 ident: 11_38406964 publication-title: British Journal of Sports Medicine – volume: 27 start-page: 65 issn: 0897-7151 issue: 1 year: 2010 ident: 21_35619192 publication-title: Journal of neurotrauma doi: 10.1089/neu.2009.0962 – volume: 21 start-page: 185 issn: 0895-8696 issue: 3 year: 2003 ident: 3_17932978 publication-title: Journal of molecular neuroscience : MN doi: 10.1385/JMN:21:3:185 – volume: 36 start-page: 228 issn: 1062-6050 issue: 3 year: 2001 ident: 17_19165171 – volume: 63 start-page: 76 issn: 0148-396X issue: 1 year: 2008 ident: 49_31791974 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000335073.39728.CE – volume: 17 start-page: 389 issn: 0897-7151 issue: 5 year: 2000 ident: 6_10332914 publication-title: Journal of neurotrauma doi: 10.1089/neu.2000.17.389 – volume: 16 start-page: 755 issn: 0967-5868 issue: 6 year: 2009 ident: 39_34742851 publication-title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia doi: 10.1016/j.jocn.2009.02.002 – volume: 62 start-page: 1286 issn: 0148-396X issue: 6 year: 2008 ident: 66_32062243 publication-title: Neurosurgery doi: 10.1227/01.NEU.0000316421.58568.AD – volume: 16 start-page: 903 issn: 0897-7151 issue: 10 year: 1999 ident: 63_6351668 publication-title: Journal of neurotrauma doi: 10.1089/neu.1999.16.903 – volume: 80 start-page: 301 issn: 0022-3085 issue: 2 year: 1994 ident: 14_14666430 publication-title: Journal of neurosurgery doi: 10.3171/jns.1994.80.2.0301 – volume: 22 start-page: 593 issn: 0278-5919 issue: 3 year: 2003 ident: 8_17713846 publication-title: Clinics in sports medicine doi: 10.1016/S0278-5919(02)00095-9 – volume: 28 start-page: 72 issn: 0195-6108 issue: 1 year: 2007 ident: 5_23453382 publication-title: American Journal of Neuroradiology – reference: - Brain. 2013 Nov;136(Pt 11):i1 |
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| SubjectTerms | 1H-magnetic resonance spectroscopy Adolescent Adult Biological and medical sciences Brain Concussion - diagnosis Brain Concussion - metabolism Brain Concussion - physiopathology Brain Diseases, Metabolic - diagnosis Brain Diseases, Metabolic - metabolism Brain Diseases, Metabolic - physiopathology Brain Injuries - diagnosis Brain Injuries - metabolism Brain Injuries - physiopathology Cohort Studies Female Humans Injuries of the nervous system and the skull. Diseases due to physical agents Magnetic Resonance Spectroscopy Male Medical sciences metabolic brain vulnerability mild traumatic brain injury N-acetylaspartate Neurology Protons Recovery of Function - physiology sport-related concussion Time Factors Traumas. Diseases due to physical agents Young Adult |
| Title | Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients |
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