DNA methylation-mediated repression of exosomal miR-652-5p expression promotes oesophageal squamous cell carcinoma aggressiveness by targeting PARG and VEGF pathways

• Published in: PLoS genetics Vol. 16; no. 4; p. e1008592
• Main Authors: Gao, Peng, Wang, Dan, Liu, Meiyue, Chen, Siyuan, Yang, Zhao, Zhang, Jie, Wang, Huan, Niu, Yi, Wang, Wei, Yang, Jilong, Sun, Guogui
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2020; Public Library of Science (PLoS)
• Subjects: Animals; Authorship; Biology and life sciences; Biomarkers; Cancer therapies; Cell cycle; Cell Movement; Cell proliferation; Cell Proliferation - genetics; CpG islands; Disease prevention; Disease Progression; DNA Methylation; Esophageal cancer; Esophageal Neoplasms - genetics; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - genetics; Esophageal Squamous Cell Carcinoma - pathology; Esophagus; Exosomes - genetics; Gene Expression Regulation, Neoplastic; Glycoside Hydrolases - metabolism; Humans; Laboratories; Lymph nodes; Lymphatic system; Medical prognosis; Medicine and Health Sciences; Metastases; Metastasis; Mice; MicroRNAs; MicroRNAs - genetics; miRNA; Neoplasm Metastasis - genetics; Oncology; Research and Analysis Methods; Ribose; Serum - cytology; Signal Transduction; Squamous cell carcinoma; Supervision; Survival Rate; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Visualization; China

Exosomal microRNAs (miRNAs) have been recently shown to play vital regulatory and communication roles in cancers. In this study, we showed that the expression levels of miR-652-5p in tumour tissues and serum samples of oesophageal squamous cell carcinoma (OSCC) patients were lower compared to non-tu...