TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

• Published in: PLoS pathogens Vol. 16; no. 3; p. e1008435
• Main Authors: Sacramento, Laís Amorim, Benevides, Luciana, Maruyama, Sandra Regina, Tavares, Lucas, Fukutani, Kiyoshi Ferreira, Francozo, Marcela, Sparwasser, Tim, Cunha, Fernando Queiroz, Almeida, Roque Pacheco, da Silva, João Santana, Carregaro, Vanessa
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2020; Public Library of Science (PLoS)
• Subjects: Biochemistry; Biology and Life Sciences; Cell activation; Chronic infection; Cytokines; Damage; Dendritic cells; Disease control; Funding; Gene expression; Gene sequencing; Health sciences; Immune response; Immune system; Immunology; Infections; Inflammation; Interferon regulatory factor 1; Liver; Lymphocytes; Lymphocytes T; Medical schools; Medicine and Health Sciences; Organs; Parasites; Parasitic diseases; Ribonucleic acid; RNA; Sequence analysis; Spleen; TLR4 protein; Toll-like receptors; Transaminase; Transcription; Vector-borne diseases; Visceral leishmaniasis; β-Interferon; γ-Interferon; Brazil; Germany
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1008435

A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the tr...