Statistics and measurable residual disease (MRD) testing: uses and abuses in hematopoietic cell transplantation

• Published in: Bone marrow transplantation (Basingstoke) Vol. 55; no. 5; pp. 843 - 850
• Main Authors: Othus, Megan, Gale, Robert Peter, Hourigan, Christopher S., Walter, Roland B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2020; Nature Publishing Group
• Subjects: 692/699/1541/1990/283/1895; 692/699/1541/1990/283/1896; 692/699/1541/1990/283/1897; 692/699/1541/1990/283/2125; 692/699/1541/1990/804; Acute myeloid leukemia; Analysis; Cancer; Cell Biology; Chemotherapy; Comorbidity; Context; Correlation analysis; Cytogenetics; Editorial; Graft vs Host Disease; Graft-versus-host reaction; Hematology; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Humans; Internal Medicine; Leukemia; Leukemia, Myeloid, Acute; Medical colleges; Medical research; Medical tests; Medicine; Medicine & Public Health; Medicine, Experimental; Mortality; Mutation; Myeloid leukemia; Neoplasm, Residual; Public Health; Recurrence; Remission; Statistical analysis; Statistics; Stem cell transplantation; Stem Cells; Survival; Transplantation; Transplants; Transplants & implants; Uncertainty

Series Editors’ Note The decision whether to recommend a transplant to someone with acute leukemia in first remission is complex and challenging. Diverse, often confounded co-variates interact to influence one’s recommendation. Briefly, the decision metric can be viewed in three spheres: (1) subject...