The clinical utility of microsatellite instability in colorectal cancer

• Published in: Critical Reviews in Oncology/Hematology Vol. 157; p. 103171
• Main Authors: Diao, Zhenli, Han, Yanxi, Chen, Yuqing, Zhang, Rui, Li, Jinming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021; Elsevier BV
• Subjects: Colorectal cancer; Colorectal Neoplasms; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Colorectal Neoplasms - therapy; Colorectal Neoplasms, Hereditary Nonpolyposis; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics; Detection; DNA Mismatch Repair; DNA Mismatch Repair - genetics; Humans; Lynch syndrome; Microsatellite Instability; Microsatellite Repeats; Predictive; Prognosis; NaMSIE; MSI-L; TGS; FDA; HRM; Prognosis; IHC; SAR; LS; Colorectal cancer; AP-PCR; HR; HRT; Microsatellite instability; ctDNA; AEs; ddPCR; DFS; FFPE; mCRC; PD-L1; LT-RPA; PFS; EC; Lynch syndrome; LOD; CE; MSI; DHPLC; OS; CI; ICBs; EDTA; MSS; ESMO; EGAPP; MMR; NaME-Pro; CRC; Predictive; NGS; Detection; MSI-H; PD-1; LNA; PCR; 5-FU

[Display omitted] Microsatellite instability (MSI) became the spotlight after the US FDA’ s approval of MSI as an indication of immunotherapy for cancer patients. Immunohistochemical detection of loss of MMR proteins and PCR amplification of specific microsatellite repeats are widely used in clinica...