Phenotypic and Functional Characterization of Lymphocytes from Different Age Groups of Bolivian Squirrel Monkeys (Saimiri boliviensis boliviensis)

• Published in: PloS one Vol. 8; no. 11; p. e79836
• Main Authors: Nehete, Pramod N., Hanley, Patrick W., Nehete, Bharti P., Yang, Guojun, Ruiz, Julio C., Williams, Lawrence, Abee, Christian R., Sastry, K. Jagannadha
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.11.2013; Public Library of Science (PLoS)
• Subjects: Adaptive Immunity; Age; Age Factors; Aging; Analogies; Animal models; Animals; Animals, Laboratory - immunology; Antigens, CD20 - metabolism; Bolivia; Bone marrow; Cancer; CD20 antigen; CD3 antigen; CD4 antigen; CD8 antigen; Creutzfeldt-Jakob disease; Cytokines; Cytokines - blood; Cytomegalovirus; Effector cells; Enzyme-Linked Immunospot Assay; Female; Females; Gerontology; Hematology; Immune response; Immune system; Immunity, Innate; Immunological memory; Immunology; Infectious diseases; Inflammation; Interferon; Interferon-gamma - metabolism; Interleukin 10; Interleukin 12; Interleukin 6; Laboratory animals; Leukocytes (mononuclear); Lymphocytes; Lymphocytes - cytology; Lymphocytes - physiology; Lymphocytes B; Lymphocytes T; Malaria; Medical research; Memory cells; Mitogens; Monkeys; Monkeys & apes; Nutrition research; Peripheral blood mononuclear cells; Phenotype; Plasma levels; Saimiri; Saimiri - immunology; Saimiri - physiology; Saimiri boliviensis; Transmissible spongiform encephalopathy; Tumor necrosis factor-α; Vector-borne diseases; γ-Interferon; Bolivia; United States > US; Texas

Due to many physiological and genetic characteristic similarities to humans, squirrel monkeys provide an ideal animal model specifically for studying malaria, and transmissible spongiform encephalopathies (Creutzfeldt-Jacob disease). While squirrel monkeys three years and older are generally conside...