A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial

• Published in: International journal of molecular sciences Vol. 24; no. 17; p. 13168
• Main Authors: Bednarska, Katarzyna, Fecka, Izabela, Scheijen, Jean L. J. M., Ahles, Sanne, Vangrieken, Philippe, Schalkwijk, Casper G.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 24.08.2023; MDPI
• Subjects: Citrus; Citrus fruits; Clinical trials; Communication; Diabetes; Dietary supplements; Double-blind studies; Flavonoids; Glucose; Mass spectrometry; Metabolism; Metabolites; Oxidative stress; Physiology; Polyphenols; Netherlands

Reactive α-dicarbonyls (α-DCs), such as methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG), are potent precursors in the formation of advanced glycation end products (AGEs). In particular, MGO and MGO-derived AGEs are thought to be involved in the development of vascular complications in...