Role of Innate Immunity in Allergic Contact Dermatitis: An Update

Our understanding of allergic contact dermatitis mechanisms has progressed over the past decade. Innate immune cells that are involved in the pathogenesis of allergic contact dermatitis include Langerhans cells, dermal dendritic cells, macrophages, mast cells, innate lymphoid cells (ILCs), neutrophi...

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Published inInternational journal of molecular sciences Vol. 24; no. 16; p. 12975
Main Authors Yamaguchi, Hiroki L, Yamaguchi, Yuji, Peeva, Elena
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2023
MDPI
Subjects
Allergens
Allergic contact dermatitis
Allergies
antigen presenting cells
atopic dermatitis
Biological response modifiers
Biopsy
Chemokines
contact hypersensitivity mice
Cytokines
Dendritic cells
Dermatitis
Eczema
Edema
Enzymes
Erythema
hapten
Immune system
Immunology
inducible skin-associated lymphoid tissue
inflammatory dendritic epidermal cells
Interferon
Interleukins
Killer cells
Lymphocytes
Neuropeptides
Neutrophils
Pathogenesis
Pharmaceutical industry
Proteins
Review
Roles
Skin diseases
T cell receptors
Tumor necrosis factor-TNF
United States
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Abstract Our understanding of allergic contact dermatitis mechanisms has progressed over the past decade. Innate immune cells that are involved in the pathogenesis of allergic contact dermatitis include Langerhans cells, dermal dendritic cells, macrophages, mast cells, innate lymphoid cells (ILCs), neutrophils, eosinophils, and basophils. ILCs can be subcategorized as group 1 (natural killer cells; ILC1) in association with Th1, group 2 (ILC2) in association with Th2, and group 3 (lymphoid tissue-inducer cells; ILC3) in association with Th17. Pattern recognition receptors (PRRs) including toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) in innate immune cells recognize damage-associated molecular patterns (DAMPs) and cascade the signal to produce several cytokines and chemokines including tumor necrosis factor (TNF)-α, interferon (IFN)-α, IFN-γ, interleukin (IL)-1β, IL-4, IL-6, IL-12, IL-13, IL-17, IL-18, and IL-23. Here we discuss the recent findings showing the roles of the innate immune system in allergic contact dermatitis during the sensitization and elicitation phases.
AbstractList Our understanding of allergic contact dermatitis mechanisms has progressed over the past decade. Innate immune cells that are involved in the pathogenesis of allergic contact dermatitis include Langerhans cells, dermal dendritic cells, macrophages, mast cells, innate lymphoid cells (ILCs), neutrophils, eosinophils, and basophils. ILCs can be subcategorized as group 1 (natural killer cells; ILC1) in association with Th1, group 2 (ILC2) in association with Th2, and group 3 (lymphoid tissue-inducer cells; ILC3) in association with Th17. Pattern recognition receptors (PRRs) including toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) in innate immune cells recognize damage-associated molecular patterns (DAMPs) and cascade the signal to produce several cytokines and chemokines including tumor necrosis factor (TNF)-α, interferon (IFN)-α, IFN-γ, interleukin (IL)-1β, IL-4, IL-6, IL-12, IL-13, IL-17, IL-18, and IL-23. Here we discuss the recent findings showing the roles of the innate immune system in allergic contact dermatitis during the sensitization and elicitation phases.
Audience Academic
Author Yamaguchi, Yuji
Yamaguchi, Hiroki L
Peeva, Elena
AuthorAffiliation 1 Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139, USA
2 Inflammation & Immunology Research Unit, Pfizer, Collegeville, PA 19426, USA
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  fullname: Yamaguchi, Yuji
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  fullname: Peeva, Elena
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Snippet Our understanding of allergic contact dermatitis mechanisms has progressed over the past decade. Innate immune cells that are involved in the pathogenesis of...
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SubjectTerms Allergens
Allergic contact dermatitis
Allergies
antigen presenting cells
atopic dermatitis
Biological response modifiers
Biopsy
Chemokines
contact hypersensitivity mice
Cytokines
Dendritic cells
Dermatitis
Eczema
Edema
Enzymes
Erythema
hapten
Immune system
Immunology
inducible skin-associated lymphoid tissue
inflammatory dendritic epidermal cells
Interferon
Interleukins
Killer cells
Lymphocytes
Neuropeptides
Neutrophils
Pathogenesis
Pharmaceutical industry
Proteins
Review
Roles
Skin diseases
T cell receptors
Tumor necrosis factor-TNF
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Title Role of Innate Immunity in Allergic Contact Dermatitis: An Update
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Volume 24
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