Dynamic water patterns change the stability of the collapsed filter conformation of the KcsA K+ channel

• Published in: PloS one Vol. 12; no. 10; p. e0186789
• Main Author: Wu, Di
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.10.2017; Public Library of Science (PLoS)
• Subjects: Bacterial Proteins - chemistry; Biology and Life Sciences; Chains; Conformation; Deactivation; Dynamic stability; Environmental factors; Hydrogen; Inactivation; Molecular dynamics; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Physical Sciences; Potassium channels; Potassium Channels - chemistry; Protein Conformation; Protein Stability; Proteins; Research and Analysis Methods; Selectivity; Simulation; Spectrum analysis; Studies; Water - chemistry; Water purification

The selectivity filter of the KcsA K+ channel has two typical conformations-the conductive and the collapsed conformations, respectively. The transition from the conductive to the collapsed filter conformation can represent the process of inactivation that depends on many environmental factors. Wate...