Potential Therapeutic Benefit of C1-Esterase Inhibitor in Neuromyelitis Optica Evaluated In Vitro and in an Experimental Rat Model - Tradtrantip, Lukmanee; Asavapanumas, Nithi; Phuan, Puay-Wah; Verkman, A. S. (PloS one, 2014)
Keywords: Angioedema; Animals; Anticoagulants; Aquaporin 4; Aquaporin 4 - immunology; Aquaporins; Astrocytes; Astrocytes - drug effects; Astrocytes - immunology; Autoantibodies; Autoantibodies - blood; Biocompatibility; Biology and Life Sciences; Central nervous system; CHO Cells; Coagulation; Complement; Complement C1 - antagonists & inhibitors; Complement C1 Inhibitor Protein - administration & dosage; Complement C1 Inhibitor Protein - pharmacology; Complement component C1; Complement system; Cricetulus; Cytotoxicity; Demyelination; Dextran; Dextran sulfate; Dextran Sulfate - pharmacology; Disease Models, Animal; Drug Synergism; Esterase; Experiments; Fibrin; Heparin; Heparin - pharmacology; Humans; Immunoglobulin G; Immunoglobulin G - adverse effects; Immunoglobulin G - immunology; Immunoglobulins; In Vitro Techniques; Inflammation; Inhibition; Inhibitors; Intravenous administration; Kallikrein; Lectins; Macromolecules; Medicine; Medicine and Health Sciences; Molecular Targeted Therapy; Neuromyelitis; Neuromyelitis Optica - blood; Neuromyelitis Optica - metabolism; Neuromyelitis Optica - pathology; Pathogenesis; Pathology; Physiology; Rats; Rats, Inbred Lew; Research and Analysis Methods; Rodents; Serine; Serine proteinase; Sulfate; Sulfates; Therapy; Toxicity; United States--US; San Francisco California; California