Statistical and network analyses reveal mechanisms for the enhancement of macrophage immunity by manganese in Mycobacterium tuberculosis infection

• Published in: Biochemistry and biophysics reports Vol. 37; p. 101602
• Main Authors: Shan, Lidong, Wang, Zihai, Wu, Lingshan, Qian, Kaiqiang, Peng, Guisen, Wei, MeiLi, Tang, Bikui, Jun, Xi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2024; Elsevier
• Subjects: Bioinformatic analysis; Manganese; Regulatory net-work; RNA sequencing; Tuberculosis; RNA sequencing; Bioinformatic analysis; Tuberculosis; Regulatory net-work; Manganese

Tuberculosis is a significant infectious disease that poses a serious risk to human health. Our previous research has indicated that manganese ions reduce the bacterial load of Mycobacterium tuberculosis in macrophages, but the exact immune defense mechanism remains unknown. Several critical protein...