Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux[S]

• Published in: Journal of lipid research Vol. 57; no. 7; pp. 1175 - 1193
• Main Authors: Meriwether, David, Sulaiman, Dawoud, Wagner, Alan, Grijalva, Victor, Kaji, Izumi, Williams, Kevin J., Yu, Liqing, Fogelman, Spencer, Volpe, Carmen, Bensinger, Steven J., Anantharamaiah, G.M., Shechter, Ishaiahu, Fogelman, Alan M., Reddy, Srinivasa T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2016; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Animals; Apolipoprotein A-I - genetics; Apolipoprotein A-I - metabolism; apolipoprotein A-I mimetic peptides; atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; Atherosclerosis - pathology; Biological Transport; cholesterol; Cholesterol - blood; Cholesterol - metabolism; Humans; Inflammation - metabolism; Inflammation - pathology; Intestine, Small - metabolism; Lipoproteins - metabolism; Macrophages - metabolism; Peptides - metabolism; reverse cholesterol transport; atherosclerosis; cholesterol; reverse cholesterol transport; apolipoprotein A-I mimetic peptides

The site and mechanism of action of the apoA-I mimetic peptide 4F are incompletely understood. Transintestinal cholesterol efflux (TICE) is a process involved in the clearance of excess cholesterol from the body. While TICE is responsible for at least 30% of the clearance of neutral sterols from the...