Acacetin Protects Mice from Staphylococcus aureus Bloodstream Infection by Inhibiting the Activity of Sortase A

• Published in: Molecules (Basel, Switzerland) Vol. 21; no. 10; p. 1285
• Main Authors: Bi, Chongwei, Dong, Xiaoyun, Zhong, Xiaobo, Cai, Hongjun, Wang, Dacheng, Wang, Lin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.09.2016; MDPI
• Subjects: Abscesses; acacetin; Animal sciences; Antibiotics; Bacteria; Breast cancer; Drug resistance; Enzymes; Gram-positive bacteria; inhibitor; Leukemia; Pathogenesis; Prostate; Proteins; R&D; renal abscess; Research & development; sortase A; Staphylococcus aureus; Staphylococcus infections; Virulence; Zoology; Zoonoses; China; sortase A; acacetin; inhibitor; renal abscess; Staphylococcus aureus

Staphylococcus aureus (S. aureus) is a major cause of infection in hospitals and communities. Widespread dissemination of multi-drug resistant S. aureus is a serious threat to the health of humans and animals. An anti-virulence strategy has been widely considered as an alternative therapeutic approa...