Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic Fungus DO14 from Dendrobium officinale

• Published in: Molecules (Basel, Switzerland) Vol. 21; no. 1; p. 14
• Main Authors: Wu, Ling-Shang, Jia, Min, Chen, Ling, Zhu, Bo, Dong, Hong-Xiu, Si, Jin-Ping, Peng, Wei, Han, Ting
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2016; MDPI
• Subjects: antifungal activities; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Aspergillus fumigatus; Bioassays; Candida albicans; Cell Line, Tumor; Cell Proliferation - drug effects; Cryptococcus neoformans; cytotoxic activities; Cytotoxicity; Dendrobium - microbiology; Dendrobium - physiology; Dendrobium officinale; Endangered & extinct species; Endophytes - chemistry; Endophytes - classification; Endophytes - isolation & purification; endophytic fungi; Fungi; HL-60 Cells; Humans; Immune system; Metabolites; Microbial Sensitivity Tests; Molecular Structure; Natural products; Natural resources; Pathogens; Pharmacy; Phylogenetics; Phylogeny; Ribosomal DNA; Saccharomycetales - chemistry; Saccharomycetales - classification; Saccharomycetales - isolation & purification; Trichophyton rubrum; China; Zhejiang China; Dendrobium officinale; cytotoxic activities; metabolites; antifungal activities; endophytic fungi

Two novel cytotoxic and antifungal constituents, (4S,6S)-6-[(1S,2R)-1, 2-dihydroxybutyl]-4-hydroxy-4-methoxytetrahydro-2H-pyran-2-one (1), (6S,2E)-6-hydroxy-3-methoxy-5-oxodec-2-enoic acid (2), together with three known compounds, LL-P880γ (3), LL-P880α (4), and Ergosta-5,7,22-trien-3b-ol (5) were i...