Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection

IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and that adjusts the composition and balance of complex cytokine responses. It is produced during immune responses by innate as well as adaptive...

Full description

Saved in:
Bibliographic Details
Published inPLoS pathogens Vol. 16; no. 2; p. e1008279
Main Authors Borst, Katharina, Flindt, Sven, Blank, Patrick, Larsen, Pia-Katharina, Chhatbar, Chintan, Skerra, Jennifer, Spanier, Julia, Hirche, Christoph, König, Martin, Alanentalo, Tomas, Hafner, Martin, Waibler, Zoe, Pfeffer, Klaus, Sexl, Veronika, Sutter, Gerd, Müller, Werner, Graalmann, Theresa, Kalinke, Ulrich
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.02.2020
Public Library of Science (PLoS)
Subjects
Animals
Antigen presentation
Antigens
Antigens, Ly - genetics
Antigens, Ly - immunology
Antiviral agents
Antiviral drugs
Autoimmune diseases
Autoimmunity
Biology and life sciences
CD4 antigen
Cytokines
Flow cytometry
Gene expression
Gene Expression Regulation - immunology
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Immune response
Immune system
Immunology
Infections
Infectious diseases
Interferon-gamma - genetics
Interferon-gamma - immunology
Killer Cells, Natural - immunology
Killer Cells, Natural - pathology
Lymphocytes
Lymphocytes T
Macrophages
Major histocompatibility complex
Medicine and health sciences
Mice
Mice, Transgenic
Natural Cytotoxicity Triggering Receptor 1 - genetics
Natural Cytotoxicity Triggering Receptor 1 - immunology
Neuropathology
Spleen
Splenocytes
T-Lymphocytes - immunology
T-Lymphocytes - pathology
Vaccinia - genetics
Vaccinia - immunology
Vaccinia - pathology
Vaccinia virus - genetics
Vaccinia virus - immunology
Viral infections
Viruses
γ-Interferon
United Kingdom > UK
Germany
Online AccessGet full text

Cover

Abstract IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and that adjusts the composition and balance of complex cytokine responses. It is produced during immune responses by innate as well as adaptive immune cells and can critically affect the course and outcome of infectious diseases, autoimmunity, and cancer. To selectively analyze the function of innate immune cell-derived IFN-γ, we generated conditional IFN-γOFF mice, in which endogenous IFN-γ expression is disrupted by a loxP flanked gene trap cassette inserted into the first intron of the IFN-γ gene. IFN-γOFF mice were intercrossed with Ncr1-Cre or CD4-Cre mice that express Cre mainly in NK cells (IFN-γNcr1-ON mice) or T cells (IFN-γCD4-ON mice), respectively. Rosa26RFP reporter mice intercrossed with Ncr1-Cre mice showed selective RFP expression in more than 80% of the NK cells, while upon intercrossing with CD4-Cre mice abundant RFP expression was detected in T cells, but also to a minor extent in other immune cell subsets. Previous studies showed that IFN-γ expression is needed to promote survival of vaccinia virus (VACV) infection. Interestingly, during VACV infection of wild type and IFN-γCD4-ON mice two waves of serum IFN-γ were induced that peaked on day 1 and day 3/4 after infection. Similarly, VACV infected IFN-γNcr1-ON mice mounted two waves of IFN-γ responses, of which the first one was moderately and the second one profoundly reduced when compared with WT mice. Furthermore, IFN-γNcr1-ON as well as IFN-γCD4-ON mice survived VACV infection, whereas IFN-γOFF mice did not. As expected, ex vivo analysis of splenocytes derived from VACV infected IFN-γNcr1-ON mice showed IFN-γ expression in NK cells, but not T cells, whereas IFN-γOFF mice showed IFN-γ expression neither in NK cells nor T cells. VACV infected IFN-γNcr1-ON mice mounted normal cytokine responses, restored neutrophil accumulation, and showed normal myeloid cell distribution in blood and spleen. Additionally, in these mice normal MHC-II expression was detected on peripheral macrophages, whereas IFN-γOFF mice did not show MHC-II expression on such cells. In conclusion, upon VACV infection Ncr1 positive cells including NK cells mount two waves of early IFN-γ responses that are sufficient to promote the induction of protective anti-viral immunity.
AbstractList IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and that adjusts the composition and balance of complex cytokine responses. It is produced during immune responses by innate as well as adaptive immune cells and can critically affect the course and outcome of infectious diseases, autoimmunity, and cancer. To selectively analyze the function of innate immune cell-derived IFN-γ, we generated conditional IFN-γOFF mice, in which endogenous IFN-γ expression is disrupted by a loxP flanked gene trap cassette inserted into the first intron of the IFN-γ gene. IFN-γOFF mice were intercrossed with Ncr1-Cre or CD4-Cre mice that express Cre mainly in NK cells (IFN-γNcr1-ON mice) or T cells (IFN-γCD4-ON mice), respectively. Rosa26RFP reporter mice intercrossed with Ncr1-Cre mice showed selective RFP expression in more than 80% of the NK cells, while upon intercrossing with CD4-Cre mice abundant RFP expression was detected in T cells, but also to a minor extent in other immune cell subsets. Previous studies showed that IFN-γ expression is needed to promote survival of vaccinia virus (VACV) infection. Interestingly, during VACV infection of wild type and IFN-γCD4-ON mice two waves of serum IFN-γ were induced that peaked on day 1 and day 3/4 after infection. Similarly, VACV infected IFN-γNcr1-ON mice mounted two waves of IFN-γ responses, of which the first one was moderately and the second one profoundly reduced when compared with WT mice. Furthermore, IFN-γNcr1-ON as well as IFN-γCD4-ON mice survived VACV infection, whereas IFN-γOFF mice did not. As expected, ex vivo analysis of splenocytes derived from VACV infected IFN-γNcr1-ON mice showed IFN-γ expression in NK cells, but not T cells, whereas IFN-γOFF mice showed IFN-γ expression neither in NK cells nor T cells. VACV infected IFN-γNcr1-ON mice mounted normal cytokine responses, restored neutrophil accumulation, and showed normal myeloid cell distribution in blood and spleen. Additionally, in these mice normal MHC-II expression was detected on peripheral macrophages, whereas IFN-γOFF mice did not show MHC-II expression on such cells. In conclusion, upon VACV infection Ncr1 positive cells including NK cells mount two waves of early IFN-γ responses that are sufficient to promote the induction of protective anti-viral immunity.
IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and that adjusts the composition and balance of complex cytokine responses. It is produced during immune responses by innate as well as adaptive immune cells and can critically affect the course and outcome of infectious diseases, autoimmunity, and cancer. To selectively analyze the function of innate immune cell-derived IFN-γ, we generated conditional IFN-γ OFF mice, in which endogenous IFN-γ expression is disrupted by a loxP flanked gene trap cassette inserted into the first intron of the IFN-γ gene. IFN-γ OFF mice were intercrossed with Ncr1-Cre or CD4-Cre mice that express Cre mainly in NK cells (IFN-γ Ncr1-ON mice) or T cells (IFN-γ CD4-ON mice), respectively. Rosa26RFP reporter mice intercrossed with Ncr1-Cre mice showed selective RFP expression in more than 80% of the NK cells, while upon intercrossing with CD4-Cre mice abundant RFP expression was detected in T cells, but also to a minor extent in other immune cell subsets. Previous studies showed that IFN-γ expression is needed to promote survival of vaccinia virus (VACV) infection. Interestingly, during VACV infection of wild type and IFN-γ CD4-ON mice two waves of serum IFN-γ were induced that peaked on day 1 and day 3/4 after infection. Similarly, VACV infected IFN-γ Ncr1-ON mice mounted two waves of IFN-γ responses, of which the first one was moderately and the second one profoundly reduced when compared with WT mice. Furthermore, IFN-γ Ncr1-ON as well as IFN-γ CD4-ON mice survived VACV infection, whereas IFN-γ OFF mice did not. As expected, ex vivo analysis of splenocytes derived from VACV infected IFN-γ Ncr1-ON mice showed IFN-γ expression in NK cells, but not T cells, whereas IFN-γ OFF mice showed IFN-γ expression neither in NK cells nor T cells. VACV infected IFN-γ Ncr1-ON mice mounted normal cytokine responses, restored neutrophil accumulation, and showed normal myeloid cell distribution in blood and spleen. Additionally, in these mice normal MHC-II expression was detected on peripheral macrophages, whereas IFN-γ OFF mice did not show MHC-II expression on such cells. In conclusion, upon VACV infection Ncr1 positive cells including NK cells mount two waves of early IFN-γ responses that are sufficient to promote the induction of protective anti-viral immunity. Viral infections induce interferon (IFN) responses that constitute a first line of defense. Type II IFN (IFN-γ) is required for protection against lethal vaccinia virus (VACV) infection. To address the cellular origin of protective IFN-γ responses during VACV infection, we generated IFN-γ OFF mice, in which the endogenous IFN-γ gene function can be reconstituted in a Cre-dependent manner. IFN-γ OFF mice were intercrossed with Ncr1-Cre mice that express Cre selectively in Ncr1 + innate cell subsests such as NK cells. Surprisingly, VACV infected IFN-γ Ncr1-ON mice mounted two waves of IFN-γ responses. Reconstitution of innate IFN-γ was sufficient to restore cytokine responses that supported normal myeloid cell distribution and survival upon VACV infection. In conclusion, IFN-γ derived from Ncr1 + innate immune cells is sufficient to elicit fully effective immune responses upon VACV infection. Our new mouse model is suitable to further address the role of Ncr1 + cell-derived IFN-γ also in other models of infection, as well as of autoimmunity and cancer.
IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and that adjusts the composition and balance of complex cytokine responses. It is produced during immune responses by innate as well as adaptive immune cells and can critically affect the course and outcome of infectious diseases, autoimmunity, and cancer. To selectively analyze the function of innate immune cell-derived IFN-γ, we generated conditional IFN-γOFF mice, in which endogenous IFN-γ expression is disrupted by a loxP flanked gene trap cassette inserted into the first intron of the IFN-γ gene. IFN-γOFF mice were intercrossed with Ncr1-Cre or CD4-Cre mice that express Cre mainly in NK cells (IFN-γNcr1-ON mice) or T cells (IFN-γCD4-ON mice), respectively. Rosa26RFP reporter mice intercrossed with Ncr1-Cre mice showed selective RFP expression in more than 80% of the NK cells, while upon intercrossing with CD4-Cre mice abundant RFP expression was detected in T cells, but also to a minor extent in other immune cell subsets. Previous studies showed that IFN-γ expression is needed to promote survival of vaccinia virus (VACV) infection. Interestingly, during VACV infection of wild type and IFN-γCD4-ON mice two waves of serum IFN-γ were induced that peaked on day 1 and day 3/4 after infection. Similarly, VACV infected IFN-γNcr1-ON mice mounted two waves of IFN-γ responses, of which the first one was moderately and the second one profoundly reduced when compared with WT mice. Furthermore, IFN-γNcr1-ON as well as IFN-γCD4-ON mice survived VACV infection, whereas IFN-γOFF mice did not. As expected, ex vivo analysis of splenocytes derived from VACV infected IFN-γNcr1-ON mice showed IFN-γ expression in NK cells, but not T cells, whereas IFN-γOFF mice showed IFN-γ expression neither in NK cells nor T cells. VACV infected IFN-γNcr1-ON mice mounted normal cytokine responses, restored neutrophil accumulation, and showed normal myeloid cell distribution in blood and spleen. Additionally, in these mice normal MHC-II expression was detected on peripheral macrophages, whereas IFN-γOFF mice did not show MHC-II expression on such cells. In conclusion, upon VACV infection Ncr1 positive cells including NK cells mount two waves of early IFN-γ responses that are sufficient to promote the induction of protective anti-viral immunity.IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and that adjusts the composition and balance of complex cytokine responses. It is produced during immune responses by innate as well as adaptive immune cells and can critically affect the course and outcome of infectious diseases, autoimmunity, and cancer. To selectively analyze the function of innate immune cell-derived IFN-γ, we generated conditional IFN-γOFF mice, in which endogenous IFN-γ expression is disrupted by a loxP flanked gene trap cassette inserted into the first intron of the IFN-γ gene. IFN-γOFF mice were intercrossed with Ncr1-Cre or CD4-Cre mice that express Cre mainly in NK cells (IFN-γNcr1-ON mice) or T cells (IFN-γCD4-ON mice), respectively. Rosa26RFP reporter mice intercrossed with Ncr1-Cre mice showed selective RFP expression in more than 80% of the NK cells, while upon intercrossing with CD4-Cre mice abundant RFP expression was detected in T cells, but also to a minor extent in other immune cell subsets. Previous studies showed that IFN-γ expression is needed to promote survival of vaccinia virus (VACV) infection. Interestingly, during VACV infection of wild type and IFN-γCD4-ON mice two waves of serum IFN-γ were induced that peaked on day 1 and day 3/4 after infection. Similarly, VACV infected IFN-γNcr1-ON mice mounted two waves of IFN-γ responses, of which the first one was moderately and the second one profoundly reduced when compared with WT mice. Furthermore, IFN-γNcr1-ON as well as IFN-γCD4-ON mice survived VACV infection, whereas IFN-γOFF mice did not. As expected, ex vivo analysis of splenocytes derived from VACV infected IFN-γNcr1-ON mice showed IFN-γ expression in NK cells, but not T cells, whereas IFN-γOFF mice showed IFN-γ expression neither in NK cells nor T cells. VACV infected IFN-γNcr1-ON mice mounted normal cytokine responses, restored neutrophil accumulation, and showed normal myeloid cell distribution in blood and spleen. Additionally, in these mice normal MHC-II expression was detected on peripheral macrophages, whereas IFN-γOFF mice did not show MHC-II expression on such cells. In conclusion, upon VACV infection Ncr1 positive cells including NK cells mount two waves of early IFN-γ responses that are sufficient to promote the induction of protective anti-viral immunity.
Author König, Martin
Müller, Werner
Hirche, Christoph
Flindt, Sven
Skerra, Jennifer
Kalinke, Ulrich
Alanentalo, Tomas
Borst, Katharina
Pfeffer, Klaus
Sexl, Veronika
Sutter, Gerd
Blank, Patrick
Hafner, Martin
Larsen, Pia-Katharina
Spanier, Julia
Waibler, Zoe
Graalmann, Theresa
Chhatbar, Chintan
AuthorAffiliation 8 Clinic for Immunology and Rheumathology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany
2 Paul-Ehrlich-Institut, Division of Immunology, Langen, Germany
4 Helmholtz Centre for Infection Research, Brunswick, Germany
Harvard Medical School, UNITED STATES
9 Cluster of Excellence—Resolving Infection Susceptibility (RESIST) (EXC 2155), Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany
7 LMU University of Munich, Institute for Infectious Diseases and Zoonoses, Munich, Germany
1 TWINCORE–Centre for Experimental and Clinical Infection Research, Institute for Experimental Infection Research, Hanover, Germany
3 European Molecular Biology Laboratory (EMBL), Mouse Biology Programme, Monterodonto, Italy
5 University of Düsseldorf, Institute of Medical Microbiology and Hospital Hygiene, Düsseldorf, Germany
6 University of Veterinary Medicine (VetmedUni), Institute for Pharmacology and Toxicology, Vienna, Austria
AuthorAffiliation_xml – name: 2 Paul-Ehrlich-Institut, Division of Immunology, Langen, Germany
– name: 6 University of Veterinary Medicine (VetmedUni), Institute for Pharmacology and Toxicology, Vienna, Austria
– name: 7 LMU University of Munich, Institute for Infectious Diseases and Zoonoses, Munich, Germany
– name: 5 University of Düsseldorf, Institute of Medical Microbiology and Hospital Hygiene, Düsseldorf, Germany
– name: 8 Clinic for Immunology and Rheumathology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany
– name: 9 Cluster of Excellence—Resolving Infection Susceptibility (RESIST) (EXC 2155), Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany
– name: 3 European Molecular Biology Laboratory (EMBL), Mouse Biology Programme, Monterodonto, Italy
– name: 4 Helmholtz Centre for Infection Research, Brunswick, Germany
– name: 1 TWINCORE–Centre for Experimental and Clinical Infection Research, Institute for Experimental Infection Research, Hanover, Germany
– name: Harvard Medical School, UNITED STATES
Author_xml – sequence: 1
  givenname: Katharina
  orcidid: 0000-0002-2999-2360
  surname: Borst
  fullname: Borst, Katharina
– sequence: 2
  givenname: Sven
  surname: Flindt
  fullname: Flindt, Sven
– sequence: 3
  givenname: Patrick
  orcidid: 0000-0002-0457-1738
  surname: Blank
  fullname: Blank, Patrick
– sequence: 4
  givenname: Pia-Katharina
  orcidid: 0000-0001-6425-3208
  surname: Larsen
  fullname: Larsen, Pia-Katharina
– sequence: 5
  givenname: Chintan
  orcidid: 0000-0002-5824-5209
  surname: Chhatbar
  fullname: Chhatbar, Chintan
– sequence: 6
  givenname: Jennifer
  orcidid: 0000-0002-8845-7683
  surname: Skerra
  fullname: Skerra, Jennifer
– sequence: 7
  givenname: Julia
  orcidid: 0000-0002-8797-3563
  surname: Spanier
  fullname: Spanier, Julia
– sequence: 8
  givenname: Christoph
  surname: Hirche
  fullname: Hirche, Christoph
– sequence: 9
  givenname: Martin
  surname: König
  fullname: König, Martin
– sequence: 10
  givenname: Tomas
  orcidid: 0000-0001-5714-0344
  surname: Alanentalo
  fullname: Alanentalo, Tomas
– sequence: 11
  givenname: Martin
  orcidid: 0000-0003-0769-1812
  surname: Hafner
  fullname: Hafner, Martin
– sequence: 12
  givenname: Zoe
  surname: Waibler
  fullname: Waibler, Zoe
– sequence: 13
  givenname: Klaus
  orcidid: 0000-0002-5652-6330
  surname: Pfeffer
  fullname: Pfeffer, Klaus
– sequence: 14
  givenname: Veronika
  surname: Sexl
  fullname: Sexl, Veronika
– sequence: 15
  givenname: Gerd
  orcidid: 0000-0001-6143-082X
  surname: Sutter
  fullname: Sutter, Gerd
– sequence: 16
  givenname: Werner
  orcidid: 0000-0002-1297-9725
  surname: Müller
  fullname: Müller, Werner
– sequence: 17
  givenname: Theresa
  surname: Graalmann
  fullname: Graalmann, Theresa
– sequence: 18
  givenname: Ulrich
  orcidid: 0000-0003-0503-9564
  surname: Kalinke
  fullname: Kalinke, Ulrich
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32023327$$D View this record in MEDLINE/PubMed
BookMark eNp9UltuEzEUHaEi-oAdILDEDxJK8HM8wwcSqihEVOED-LY8nuvgaGIH2xOpf90CO2AP7IAFsAhWwkySVm2F-LLle865516f4-LABw9F8ZjgKWGSvFyGPnrdTddrnacE44rK-l5xRIRgE8kkP7hxPyyOU1pizAkj5YPikFFMGaPyqLj8BB2Y7DaAIpjgU3a5zy54FCyanc3_XH7__RMtwAOyvTfbivNobiJ58evH_AMy0HUJuYRSb60zDnxGOaBBKsfQoXSRMqycQRttjPNOo42L_UDwFrZqD4v7VncJHu3Pk-LL2dvPp-8n5x_fzU7fnE-MoGWeMF0RILRtBSWk5Rw3uKYth6o0RGJbYdpQWktCeWWgrmuopWxL3hioKllpy06KpzvddReS2i8vKcqklFgQUQ-I2Q7RBr1U6-hWOl6ooJ3aPoS4UDpmZzpQopG1LAWhuqVcs1YT3pQN5kJbK8qSD1qv9936ZgWtGbYSdXdL9HbFu69qETZKYlrRajTzfC8Qw7ceUlYrl8Zdaw-hH30LinldlnKAPrsD_fd0T246urZyFYUBwHcAE0NKEew1hGA1Ju5KVo2JU_vEDbRXd2jGZT3-7DCX6_5P_gtk8uLC
CitedBy_id crossref_primary_10_1016_j_jep_2022_116070
crossref_primary_10_33086_ijmlst_v6i2_5746
crossref_primary_10_3390_pharmaceutics16111349
crossref_primary_10_1016_j_jmb_2021_167266
crossref_primary_10_1016_j_celrep_2020_107951
crossref_primary_10_3389_fimmu_2020_593901
crossref_primary_10_1016_j_virs_2024_08_008
crossref_primary_10_3390_pharmaceutics13101533
crossref_primary_10_1111_imr_13037
crossref_primary_10_1084_jem_20230194
crossref_primary_10_1111_febs_16073
crossref_primary_10_3389_fimmu_2023_1267369
crossref_primary_10_4049_jimmunol_2300283
Cites_doi 10.1086/426866
10.4049/jimmunol.1202448
10.4049/jimmunol.1103474
10.1016/j.cell.2015.08.004
10.1016/j.cellimm.2007.06.005
10.1146/annurev.immunol.14.1.301
10.1016/j.it.2015.07.004
10.1111/j.1365-2567.2009.03120.x
10.4049/jimmunol.0802741
10.1016/j.cellimm.2011.03.007
10.1016/j.immuni.2015.05.011
10.1016/j.celrep.2012.06.001
10.1002/jmv.1890230412
10.1101/gad.12.11.1599
10.1016/S1074-7613(01)00227-8
10.4049/jimmunol.1000844
10.4049/jimmunol.140.12.4245
10.1038/ni.3398
10.1126/science.8456301
10.1084/jem.156.6.1780
10.1016/j.cytogfr.2009.02.004
10.1128/JVI.01894-15
10.1164/rccm.201204-0645OC
10.1016/j.coi.2017.03.010
10.1038/ni.3482
10.1371/journal.pone.0018924
10.1073/pnas.1118834109
10.1128/JVI.79.1.661-667.2005
10.4049/jimmunol.1001893
10.1084/jem.182.4.1045
10.4049/jimmunol.1202714
10.4049/jimmunol.172.10.6265
10.4049/jimmunol.1200038
10.1073/pnas.1218767110
10.4049/jimmunol.1502673
10.1002/eji.201344134
10.1182/blood-2009-12-259630
10.1038/ni.3619
10.1182/blood-2011-07-367706
10.1002/eji.200636745
10.4049/jimmunol.131.3.1531
10.1073/pnas.0502273102
10.1016/j.cytogfr.2004.03.009
10.1073/pnas.93.12.5860
10.1016/j.immuni.2019.09.009
10.1016/j.vetimm.2011.07.006
10.1128/JVI.69.8.4633-4639.1995
10.1371/journal.ppat.0040027
10.1016/S0923-2516(89)80126-8
10.4049/jimmunol.1001990
10.1016/j.cell.2012.07.021
10.1182/blood-2010-06-291633
10.1038/ni.3375
10.1126/science.8456300
10.1089/jir.2007.0113
10.1016/j.immuni.2019.09.012
10.1099/vir.0.19120-0
10.1128/JVI.02176-14
10.1128/JVI.02626-06
10.4049/jimmunol.180.3.1592
10.1016/j.cell.2017.09.052
10.4049/jimmunol.1200799
10.1084/jem.191.5.771
10.4049/jimmunol.179.12.8243
10.1016/j.coi.2015.11.007
10.1189/jlb.0603252
10.1002/eji.1830230514
10.1007/s00281-008-0132-5
10.1002/eji.201142072
10.1056/NEJM198906293202605
10.1016/j.cyto.2017.05.019
10.1016/j.immuni.2012.03.026
10.1371/journal.ppat.1002141
10.1182/blood-2010-11-316653
10.1016/j.vaccine.2012.11.062
10.1038/nature10624
10.4049/jimmunol.1400256
10.4049/jimmunol.1004122
10.1128/JVI.75.7.3185-3196.2001
10.1038/s41577-018-0029-z
10.1128/CVI.00357-07
10.4049/jimmunol.1003166
10.1016/j.jaci.2013.07.020
10.1038/nm0697-678
ContentType Journal Article
Copyright 2020 Borst et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2020 Borst et al 2020 Borst et al
Copyright_xml – notice: 2020 Borst et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2020 Borst et al 2020 Borst et al
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7U9
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1371/journal.ppat.1008279
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Virology and AIDS Abstracts
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni)
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Health & Medical Research Collection
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE



MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
DocumentTitleAlternate Ncr1-specific IFN-γ expression during VACV infection
EISSN 1553-7374
ExternalDocumentID 2377705159
oai_doaj_org_article_5b7976512ad24a3da14b6b045aff5664
PMC7028289
32023327
10_1371_journal_ppat_1008279
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations United Kingdom--UK
Germany
GeographicLocations_xml – name: United Kingdom--UK
– name: Germany
GrantInformation_xml – fundername: ;
  grantid: QLK2-CT-2001-02103
– fundername: ;
  grantid: 406922110
– fundername: ;
  grantid: IRTG1273
– fundername: ;
  grantid: ZT-0027
GroupedDBID ---
123
29O
2WC
53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALMA_UNASSIGNED_HOLDINGS
AOIJS
B0M
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EAP
EAS
EBD
EMK
EMOBN
ESX
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IHR
INH
INR
ISN
ISR
ITC
KQ8
LK8
M1P
M48
M7P
MM.
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PV9
QF4
QN7
RNS
RPM
RZL
SV3
TR2
TUS
UKHRP
WOW
~8M
3V.
ADRAZ
CGR
CUY
CVF
ECM
EIF
H13
IPNFZ
M~E
NPM
RIG
WOQ
7QL
7U9
7XB
8FK
AZQEC
C1K
DWQXO
GNUQQ
H94
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
7X8
5PM
PUEGO
-
AAPBV
ABPTK
ADACO
BBAFP
ID FETCH-LOGICAL-c526t-3a81e12dd5211d440b092d4e86c170f802b22971248ce999e977d64bce8878af3
IEDL.DBID 7X7
ISSN 1553-7374
1553-7366
IngestDate Fri Nov 26 17:13:42 EST 2021
Wed Aug 27 01:14:16 EDT 2025
Thu Aug 21 18:20:32 EDT 2025
Mon Jul 21 11:16:44 EDT 2025
Fri Jul 25 12:05:48 EDT 2025
Wed Feb 19 02:30:11 EST 2025
Thu Apr 24 23:07:18 EDT 2025
Tue Jul 01 03:38:34 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c526t-3a81e12dd5211d440b092d4e86c170f802b22971248ce999e977d64bce8878af3
Notes new_version
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Current address: Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
Current address: Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Current address: Paul-Ehrlich-Institut, Research Group for Novel Vaccination Strategies and Early Immune Responses, Langen, Germany
The authors have declared that no competing interests exist.
Current address: Novo Nordisk A/S, Diabetes Research, Histology & Imaging, Maaloev, Denmark
Current address: Institute for Genetics, University of Cologne, Cologne, Germany
TG and UK also contributed equally to this work.
Current address: Biotest AG, Dreieich, Germany
ORCID 0000-0002-8797-3563
0000-0001-5714-0344
0000-0002-0457-1738
0000-0002-2999-2360
0000-0002-5824-5209
0000-0001-6143-082X
0000-0002-5652-6330
0000-0002-1297-9725
0000-0001-6425-3208
0000-0003-0503-9564
0000-0003-0769-1812
0000-0002-8845-7683
OpenAccessLink https://www.proquest.com/docview/2377705159?pq-origsite=%requestingapplication%
PMID 32023327
PQID 2377705159
PQPubID 1436335
ParticipantIDs plos_journals_2377705159
doaj_primary_oai_doaj_org_article_5b7976512ad24a3da14b6b045aff5664
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7028289
proquest_miscellaneous_2352049667
proquest_journals_2377705159
pubmed_primary_32023327
crossref_primary_10_1371_journal_ppat_1008279
crossref_citationtrail_10_1371_journal_ppat_1008279
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-02-01
PublicationDateYYYYMMDD 2020-02-01
PublicationDate_xml – month: 02
  year: 2020
  text: 2020-02-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PLoS pathogens
PublicationTitleAlternate PLoS Pathog
PublicationYear 2020
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References PP Lee (ppat.1008279.ref031) 2001; 15
GO Gillard (ppat.1008279.ref081) 2011; 7
J Goulding (ppat.1008279.ref014) 2012; 189
J Leentjens (ppat.1008279.ref072) 2012; 186
S Eickhoff (ppat.1008279.ref029) 2015; 162
J Storek (ppat.1008279.ref077) 2008; 30
S Huang (ppat.1008279.ref017) 1993; 259
KM Eichinger (ppat.1008279.ref075) 2017; 97
N Gill (ppat.1008279.ref009) 2011; 269
A Alcami (ppat.1008279.ref036) 1995; 69
K Soderquest (ppat.1008279.ref060) 2011; 186
AM de Bruin (ppat.1008279.ref045) 2012; 119
V Fang (ppat.1008279.ref050) 2017; 18
E Eckelhart (ppat.1008279.ref032) 2011; 117
LB Ivashkiv (ppat.1008279.ref058) 2018; 18
BE Mota (ppat.1008279.ref030) 2011; 6
A Billiau (ppat.1008279.ref002) 2009; 20
OE Weizman (ppat.1008279.ref042) 2017; 171
P Novy (ppat.1008279.ref011) 2007; 179
PM Sawant (ppat.1008279.ref074) 2011; 144
P Gais (ppat.1008279.ref085) 2012; 188
KC MacNamara (ppat.1008279.ref047) 2011; 186
PA Lang (ppat.1008279.ref063) 2012; 109
TF Gajewski (ppat.1008279.ref001) 1988; 140
M Thapa (ppat.1008279.ref004) 2007; 81
K Borst (ppat.1008279.ref019) 2017
H Zhang (ppat.1008279.ref046) 2010; 116
KD Cook (ppat.1008279.ref062) 2013; 190
M Wiesel (ppat.1008279.ref013) 2011; 186
J Goulding (ppat.1008279.ref018) 2014; 192
M Lakso (ppat.1008279.ref082) 1996; 93
JL Coombes (ppat.1008279.ref051) 2012; 2
CA Biron (ppat.1008279.ref068) 1989; 320
SC Cheng (ppat.1008279.ref071) 2016; 17
JS Orange (ppat.1008279.ref003) 1995; 182
HW Snoeck (ppat.1008279.ref048) 1993; 23
BA Mann (ppat.1008279.ref037) 2008; 28
M Fang (ppat.1008279.ref057) 2015; 89
K Schroder (ppat.1008279.ref044) 2004; 75
MK Kennedy (ppat.1008279.ref010) 2000; 191
F Novelli (ppat.1008279.ref069) 2004; 15
YP Wang (ppat.1008279.ref073) 2013; 31
F Fenner (ppat.1008279.ref016) 1989; 140
G Abboud (ppat.1008279.ref025) 2015; 90
I Barao (ppat.1008279.ref078) 2011; 117
AI Lim (ppat.1008279.ref033) 2017; 44
J Loh (ppat.1008279.ref008) 2005; 79
W Kastenmuller (ppat.1008279.ref022) 2012; 150
BR Long (ppat.1008279.ref080) 2008; 15
N Wang (ppat.1008279.ref056) 2009; 183
F Schnutgen (ppat.1008279.ref084) 2005; 102
B Becher (ppat.1008279.ref039) 2019; 51
MT Vossen (ppat.1008279.ref067) 2005; 191
A Horowitz (ppat.1008279.ref079) 2010; 185
M Wiesel (ppat.1008279.ref012) 2010; 185
R Xu (ppat.1008279.ref015) 2004; 172
B Mach (ppat.1008279.ref028) 1996; 14
CM Sungur (ppat.1008279.ref076) 2013; 110
P Najarro (ppat.1008279.ref038) 2001; 75
A Rivera (ppat.1008279.ref053) 2016; 17
T Strowig (ppat.1008279.ref005) 2008; 4
H Spits (ppat.1008279.ref043) 2016; 17
B. Reizis (ppat.1008279.ref040) 2019; 51
T Pembroke (ppat.1008279.ref065) 2012; 42
E Robanus-Maandag (ppat.1008279.ref086) 1998; 12
JS Orange (ppat.1008279.ref066) 2013; 132
C Fortin (ppat.1008279.ref023) 2013; 191
T Verrier (ppat.1008279.ref041) 2016; 196
AF Alice (ppat.1008279.ref059) 2018; 200
TK Erick (ppat.1008279.ref034) 2016; 38
Y Yao (ppat.1008279.ref055) 2007; 246
SN Waggoner (ppat.1008279.ref064) 2011; 481
H Luche (ppat.1008279.ref083) 2007; 37
JF Bukowski (ppat.1008279.ref026) 1983; 131
MH Askenase (ppat.1008279.ref049) 2015; 42
JD Brandstadter (ppat.1008279.ref020) 2014; 44
PS Steeg (ppat.1008279.ref027) 1982; 156
WD Döcke (ppat.1008279.ref070) 1997; 3
RS Goldszmid (ppat.1008279.ref052) 2012; 36
DK Dalton (ppat.1008279.ref035) 1993; 259
MQ Ge (ppat.1008279.ref007) 2012; 189
MM Gherardi (ppat.1008279.ref024) 2003; 84
D Guyotat (ppat.1008279.ref006) 1987; 23
CE Rydyznski (ppat.1008279.ref061) 2015; 36
KE Rehm (ppat.1008279.ref054) 2009; 128
J Martinez (ppat.1008279.ref021) 2008; 180
References_xml – volume: 191
  start-page: 198
  issue: 2
  year: 2005
  ident: ppat.1008279.ref067
  article-title: Absence of circulating natural killer and primed CD8+ cells in life-threatening varicella
  publication-title: J Infect Dis
  doi: 10.1086/426866
– volume: 190
  start-page: 641
  issue: 2
  year: 2013
  ident: ppat.1008279.ref062
  article-title: The depletion of NK cells prevents T cell exhaustion to efficiently control disseminating virus infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1202448
– volume: 189
  start-page: 2099
  issue: 5
  year: 2012
  ident: ppat.1008279.ref007
  article-title: NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-gamma and perforin-dependent mechanisms
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1103474
– volume: 162
  start-page: 1322
  issue: 6
  year: 2015
  ident: ppat.1008279.ref029
  article-title: Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.004
– volume: 246
  start-page: 92
  issue: 2
  year: 2007
  ident: ppat.1008279.ref055
  article-title: Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II
  publication-title: Cell Immunol
  doi: 10.1016/j.cellimm.2007.06.005
– volume: 14
  start-page: 301
  year: 1996
  ident: ppat.1008279.ref028
  article-title: Regulation of MHC class II genes: lessons from a disease
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev.immunol.14.1.301
– volume: 36
  start-page: 536
  issue: 9
  year: 2015
  ident: ppat.1008279.ref061
  article-title: Boosting vaccine efficacy the natural (killer) way
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2015.07.004
– volume: 128
  start-page: 381
  issue: 3
  year: 2009
  ident: ppat.1008279.ref054
  article-title: Vaccinia virus decreases major histocompatibility complex (MHC) class II antigen presentation, T-cell priming, and peptide association with MHC class II
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2009.03120.x
– volume: 183
  start-page: 1542
  issue: 3
  year: 2009
  ident: ppat.1008279.ref056
  article-title: Diminished intracellular invariant chain expression after vaccinia virus infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0802741
– volume: 269
  start-page: 29
  issue: 1
  year: 2011
  ident: ppat.1008279.ref009
  article-title: NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection
  publication-title: Cell Immunol
  doi: 10.1016/j.cellimm.2011.03.007
– volume: 42
  start-page: 1130
  issue: 6
  year: 2015
  ident: ppat.1008279.ref049
  article-title: Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.05.011
– volume: 2
  start-page: 124
  issue: 1
  year: 2012
  ident: ppat.1008279.ref051
  article-title: Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2012.06.001
– volume: 23
  start-page: 393
  issue: 4
  year: 1987
  ident: ppat.1008279.ref006
  article-title: Incidence and prognosis of cytomegalovirus infections following allogenic bone marrow transplantation
  publication-title: J Med Virol
  doi: 10.1002/jmv.1890230412
– year: 2017
  ident: ppat.1008279.ref019
  article-title: Type I interferon receptor-signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis
  publication-title: J Hepatol
– volume: 12
  start-page: 1599
  issue: 11
  year: 1998
  ident: ppat.1008279.ref086
  article-title: p107 is a suppressor of retinoblastoma development in pRb-deficient mice
  publication-title: Genes Dev
  doi: 10.1101/gad.12.11.1599
– volume: 15
  start-page: 763
  issue: 5
  year: 2001
  ident: ppat.1008279.ref031
  article-title: A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
  publication-title: Immunity
  doi: 10.1016/S1074-7613(01)00227-8
– volume: 185
  start-page: 2808
  issue: 5
  year: 2010
  ident: ppat.1008279.ref079
  article-title: NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1000844
– volume: 140
  start-page: 4245
  issue: 12
  year: 1988
  ident: ppat.1008279.ref001
  article-title: Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones
  publication-title: J Immunol
  doi: 10.4049/jimmunol.140.12.4245
– volume: 17
  start-page: 406
  issue: 4
  year: 2016
  ident: ppat.1008279.ref071
  article-title: Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis
  publication-title: Nat Immunol
  doi: 10.1038/ni.3398
– volume: 259
  start-page: 1742
  issue: 5102
  year: 1993
  ident: ppat.1008279.ref017
  article-title: Immune response in mice that lack the interferon-gamma receptor
  publication-title: Science
  doi: 10.1126/science.8456301
– volume: 156
  start-page: 1780
  issue: 6
  year: 1982
  ident: ppat.1008279.ref027
  article-title: Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity
  publication-title: J Exp Med
  doi: 10.1084/jem.156.6.1780
– volume: 20
  start-page: 97
  issue: 2
  year: 2009
  ident: ppat.1008279.ref002
  article-title: Interferon-gamma: a historical perspective
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2009.02.004
– volume: 90
  start-page: 129
  issue: 1
  year: 2015
  ident: ppat.1008279.ref025
  article-title: Natural Killer Cells and Innate Interferon Gamma Participate in the Host Defense against Respiratory Vaccinia Virus Infection
  publication-title: J Virol
  doi: 10.1128/JVI.01894-15
– volume: 186
  start-page: 838
  issue: 9
  year: 2012
  ident: ppat.1008279.ref072
  article-title: Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201204-0645OC
– volume: 44
  start-page: 61
  year: 2017
  ident: ppat.1008279.ref033
  article-title: Developmental options and functional plasticity of innate lymphoid cells
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2017.03.010
– volume: 17
  start-page: 758
  issue: 7
  year: 2016
  ident: ppat.1008279.ref043
  article-title: NK cells and type 1 innate lymphoid cells: partners in host defense
  publication-title: Nat Immunol
  doi: 10.1038/ni.3482
– volume: 6
  start-page: e18924
  issue: 4
  year: 2011
  ident: ppat.1008279.ref030
  article-title: Adverse events post smallpox-vaccination: insights from tail scarification infection in mice with Vaccinia virus
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0018924
– volume: 109
  start-page: 1210
  issue: 4
  year: 2012
  ident: ppat.1008279.ref063
  article-title: Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1118834109
– volume: 79
  start-page: 661
  issue: 1
  year: 2005
  ident: ppat.1008279.ref008
  article-title: Virgin HWt. Natural killer cells utilize both perforin and gamma interferon to regulate murine cytomegalovirus infection in the spleen and liver
  publication-title: J Virol
  doi: 10.1128/JVI.79.1.661-667.2005
– volume: 186
  start-page: 1032
  issue: 2
  year: 2011
  ident: ppat.1008279.ref047
  article-title: Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-gamma signaling
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1001893
– volume: 182
  start-page: 1045
  issue: 4
  year: 1995
  ident: ppat.1008279.ref003
  article-title: Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
  publication-title: J Exp Med
  doi: 10.1084/jem.182.4.1045
– volume: 191
  start-page: 363
  issue: 1
  year: 2013
  ident: ppat.1008279.ref023
  article-title: Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1202714
– volume: 200
  start-page: 177
  issue: 1
  year: 2018
  ident: ppat.1008279.ref059
  publication-title: Amplifying IFN-gamma Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity
– volume: 172
  start-page: 6265
  issue: 10
  year: 2004
  ident: ppat.1008279.ref015
  article-title: Cellular and humoral immunity against vaccinia virus infection of mice
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.10.6265
– volume: 188
  start-page: 5833
  issue: 12
  year: 2012
  ident: ppat.1008279.ref085
  article-title: Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1200038
– volume: 110
  start-page: 7401
  issue: 18
  year: 2013
  ident: ppat.1008279.ref076
  article-title: Murine natural killer cell licensing and regulation by T regulatory cells in viral responses
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1218767110
– volume: 196
  start-page: 4731
  issue: 11
  year: 2016
  ident: ppat.1008279.ref041
  article-title: Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1502673
– volume: 44
  start-page: 2659
  issue: 9
  year: 2014
  ident: ppat.1008279.ref020
  article-title: NK cell-extrinsic IL-18 signaling is required for efficient NK-cell activation by vaccinia virus
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201344134
– volume: 116
  start-page: 2462
  issue: 14
  year: 2010
  ident: ppat.1008279.ref046
  article-title: STAT3 controls myeloid progenitor growth during emergency granulopoiesis
  publication-title: Blood
  doi: 10.1182/blood-2009-12-259630
– volume: 18
  start-page: 15
  issue: 1
  year: 2017
  ident: ppat.1008279.ref050
  article-title: Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-gamma response
  publication-title: Nat Immunol
  doi: 10.1038/ni.3619
– volume: 119
  start-page: 1543
  issue: 6
  year: 2012
  ident: ppat.1008279.ref045
  article-title: IFNgamma induces monopoiesis and inhibits neutrophil development during inflammation
  publication-title: Blood
  doi: 10.1182/blood-2011-07-367706
– volume: 37
  start-page: 43
  issue: 1
  year: 2007
  ident: ppat.1008279.ref083
  article-title: Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies
  publication-title: Eur J Immunol
  doi: 10.1002/eji.200636745
– volume: 131
  start-page: 1531
  issue: 3
  year: 1983
  ident: ppat.1008279.ref026
  article-title: Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo
  publication-title: J Immunol
  doi: 10.4049/jimmunol.131.3.1531
– volume: 102
  start-page: 7221
  issue: 20
  year: 2005
  ident: ppat.1008279.ref084
  article-title: Genomewide production of multipurpose alleles for the functional analysis of the mouse genome
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0502273102
– volume: 15
  start-page: 367
  issue: 5
  year: 2004
  ident: ppat.1008279.ref069
  article-title: The role of IL-12, IL-23 and IFN-gamma in immunity to viruses
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2004.03.009
– volume: 93
  start-page: 5860
  issue: 12
  year: 1996
  ident: ppat.1008279.ref082
  article-title: Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.93.12.5860
– volume: 51
  start-page: 593
  issue: 4
  year: 2019
  ident: ppat.1008279.ref040
  article-title: The Specificity of Conditional Gene Targeting: A Case for Cre Reporters
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.09.009
– volume: 144
  start-page: 36
  issue: 1–2
  year: 2011
  ident: ppat.1008279.ref074
  article-title: Immunomodulation of bivalent Newcastle disease DNA vaccine induced immune response by co-delivery of chicken IFN-gamma and IL-4 genes
  publication-title: Vet Immunol Immunopathol
  doi: 10.1016/j.vetimm.2011.07.006
– volume: 69
  start-page: 4633
  issue: 8
  year: 1995
  ident: ppat.1008279.ref036
  article-title: Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity
  publication-title: J Virol
  doi: 10.1128/JVI.69.8.4633-4639.1995
– volume: 4
  start-page: e27
  issue: 2
  year: 2008
  ident: ppat.1008279.ref005
  article-title: Tonsilar NK cells restrict B cell transformation by the Epstein-Barr virus via IFN-gamma
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.0040027
– volume: 140
  start-page: 465
  issue: 5
  year: 1989
  ident: ppat.1008279.ref016
  article-title: Risks and benefits of vaccinia vaccine use in the worldwide smallpox eradication campaign
  publication-title: Res Virol
  doi: 10.1016/S0923-2516(89)80126-8
– volume: 185
  start-page: 5188
  issue: 9
  year: 2010
  ident: ppat.1008279.ref012
  article-title: Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1001990
– volume: 150
  start-page: 1235
  issue: 6
  year: 2012
  ident: ppat.1008279.ref022
  article-title: A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread
  publication-title: Cell
  doi: 10.1016/j.cell.2012.07.021
– volume: 117
  start-page: 1565
  issue: 5
  year: 2011
  ident: ppat.1008279.ref032
  article-title: A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development
  publication-title: Blood
  doi: 10.1182/blood-2010-06-291633
– volume: 17
  start-page: 356
  issue: 4
  year: 2016
  ident: ppat.1008279.ref053
  article-title: Innate cell communication kick-starts pathogen-specific immunity
  publication-title: Nat Immunol
  doi: 10.1038/ni.3375
– volume: 259
  start-page: 1739
  issue: 5102
  year: 1993
  ident: ppat.1008279.ref035
  article-title: Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
  publication-title: Science
  doi: 10.1126/science.8456300
– volume: 28
  start-page: 367
  issue: 6
  year: 2008
  ident: ppat.1008279.ref037
  article-title: Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons
  publication-title: J Interferon Cytokine Res
  doi: 10.1089/jir.2007.0113
– volume: 51
  start-page: 595
  issue: 4
  year: 2019
  ident: ppat.1008279.ref039
  article-title: Cre-lox: Target Sensitivity Matters
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.09.012
– volume: 84
  start-page: 1961
  issue: Pt 8
  year: 2003
  ident: ppat.1008279.ref024
  article-title: IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the immune system
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.19120-0
– volume: 89
  start-page: 776
  issue: 1
  year: 2015
  ident: ppat.1008279.ref057
  article-title: CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization
  publication-title: J Virol
  doi: 10.1128/JVI.02176-14
– volume: 81
  start-page: 3704
  issue: 8
  year: 2007
  ident: ppat.1008279.ref004
  article-title: Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization
  publication-title: J Virol
  doi: 10.1128/JVI.02626-06
– volume: 180
  start-page: 1592
  issue: 3
  year: 2008
  ident: ppat.1008279.ref021
  article-title: Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.3.1592
– volume: 171
  start-page: 795
  issue: 4
  year: 2017
  ident: ppat.1008279.ref042
  article-title: ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
  publication-title: Cell
  doi: 10.1016/j.cell.2017.09.052
– volume: 189
  start-page: 2432
  issue: 5
  year: 2012
  ident: ppat.1008279.ref014
  article-title: CD8 T cells are essential for recovery from a respiratory vaccinia virus infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1200799
– volume: 191
  start-page: 771
  issue: 5
  year: 2000
  ident: ppat.1008279.ref010
  article-title: Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
  publication-title: J Exp Med
  doi: 10.1084/jem.191.5.771
– volume: 179
  start-page: 8243
  issue: 12
  year: 2007
  ident: ppat.1008279.ref011
  article-title: CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.12.8243
– volume: 38
  start-page: 67
  year: 2016
  ident: ppat.1008279.ref034
  article-title: Phenotype and functions of conventional and non-conventional NK cells
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2015.11.007
– volume: 75
  start-page: 163
  issue: 2
  year: 2004
  ident: ppat.1008279.ref044
  article-title: Interferon-gamma: an overview of signals, mechanisms and functions
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0603252
– volume: 23
  start-page: 1072
  issue: 5
  year: 1993
  ident: ppat.1008279.ref048
  article-title: Interferon-gamma and interleukin-4 reciprocally regulate the production of monocytes/macrophages and neutrophils through a direct effect on committed monopotential bone marrow progenitor cells
  publication-title: Eur J Immunol
  doi: 10.1002/eji.1830230514
– volume: 30
  start-page: 425
  issue: 4
  year: 2008
  ident: ppat.1008279.ref077
  article-title: Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
  publication-title: Semin Immunopathol
  doi: 10.1007/s00281-008-0132-5
– volume: 42
  start-page: 2383
  issue: 9
  year: 2012
  ident: ppat.1008279.ref065
  article-title: Rapid early innate control of hepatitis C virus during IFN-alpha treatment compromises adaptive CD4+ T-cell immunity
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201142072
– volume: 320
  start-page: 1731
  issue: 26
  year: 1989
  ident: ppat.1008279.ref068
  article-title: Severe herpesvirus infections in an adolescent without natural killer cells
  publication-title: N Engl J Med
  doi: 10.1056/NEJM198906293202605
– volume: 97
  start-page: 25
  year: 2017
  ident: ppat.1008279.ref075
  article-title: Age predicts cytokine kinetics and innate immune cell activation following intranasal delivery of IFNgamma and GM-CSF in a mouse model of RSV infection
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2017.05.019
– volume: 36
  start-page: 1047
  issue: 6
  year: 2012
  ident: ppat.1008279.ref052
  article-title: NK cell-derived interferon-gamma orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.03.026
– volume: 7
  start-page: e1002141
  issue: 8
  year: 2011
  ident: ppat.1008279.ref081
  article-title: Thy1+ NK cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1002141
– volume: 117
  start-page: 7032
  issue: 26
  year: 2011
  ident: ppat.1008279.ref078
  article-title: Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC
  publication-title: Blood
  doi: 10.1182/blood-2010-11-316653
– volume: 31
  start-page: 833
  issue: 5
  year: 2013
  ident: ppat.1008279.ref073
  article-title: Enhanced protective immune response to PCV2 subunit vaccine by co-administration of recombinant porcine IFN-gamma in mice
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.11.062
– volume: 481
  start-page: 394
  issue: 7381
  year: 2011
  ident: ppat.1008279.ref064
  article-title: Natural killer cells act as rheostats modulating antiviral T cells
  publication-title: Nature
  doi: 10.1038/nature10624
– volume: 192
  start-page: 5415
  issue: 11
  year: 2014
  ident: ppat.1008279.ref018
  article-title: CD8 T cells use IFN-gamma to protect against the lethal effects of a respiratory poxvirus infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1400256
– volume: 186
  start-page: 3304
  issue: 6
  year: 2011
  ident: ppat.1008279.ref060
  article-title: Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1004122
– volume: 75
  start-page: 3185
  issue: 7
  year: 2001
  ident: ppat.1008279.ref038
  article-title: Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation
  publication-title: J Virol
  doi: 10.1128/JVI.75.7.3185-3196.2001
– volume: 18
  start-page: 545
  issue: 9
  year: 2018
  ident: ppat.1008279.ref058
  article-title: IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
  publication-title: Nat Rev Immunol
  doi: 10.1038/s41577-018-0029-z
– volume: 15
  start-page: 120
  issue: 1
  year: 2008
  ident: ppat.1008279.ref080
  article-title: Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus
  publication-title: Clin Vaccine Immunol
  doi: 10.1128/CVI.00357-07
– volume: 186
  start-page: 754
  issue: 2
  year: 2011
  ident: ppat.1008279.ref013
  article-title: Type I IFN substitutes for T cell help during viral infections
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1003166
– volume: 132
  start-page: 515
  issue: 3
  year: 2013
  ident: ppat.1008279.ref066
  article-title: Natural killer cell deficiency
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2013.07.020
– volume: 3
  start-page: 678
  issue: 6
  year: 1997
  ident: ppat.1008279.ref070
  article-title: Monocyte deactivation in septic patients: restoration by IFN-gamma treatment
  publication-title: Nat Med
  doi: 10.1038/nm0697-678
SSID ssj0041316
Score 2.3856125
Snippet IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and...
SourceID plos
doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e1008279
SubjectTerms Animals
Antigen presentation
Antigens
Antigens, Ly - genetics
Antigens, Ly - immunology
Antiviral agents
Antiviral drugs
Autoimmune diseases
Autoimmunity
Biology and life sciences
CD4 antigen
Cytokines
Flow cytometry
Gene expression
Gene Expression Regulation - immunology
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Immune response
Immune system
Immunology
Infections
Infectious diseases
Interferon-gamma - genetics
Interferon-gamma - immunology
Killer Cells, Natural - immunology
Killer Cells, Natural - pathology
Lymphocytes
Lymphocytes T
Macrophages
Major histocompatibility complex
Medicine and health sciences
Mice
Mice, Transgenic
Natural Cytotoxicity Triggering Receptor 1 - genetics
Natural Cytotoxicity Triggering Receptor 1 - immunology
Neuropathology
Spleen
Splenocytes
T-Lymphocytes - immunology
T-Lymphocytes - pathology
Vaccinia - genetics
Vaccinia - immunology
Vaccinia - pathology
Vaccinia virus - genetics
Vaccinia virus - immunology
Viral infections
Viruses
γ-Interferon
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELZQJSQuiPLXpQUZiRsK3diOnT0WxKqA2AtU6i3yr4hUJavNbiVufQXegHfgDXiAPgRPwoztXe2iSr1wzdhJ7Bl7vnEm3xDyStfCVAwWoAxcFsIGWZigRKF1JY1HCn6NB_qfZ_L0THw8r863Sn1hTliiB04Td1wZBR4T3JJ2TGjudCmMNABEdAgARSITKPi8dTCV9mDYmWPRUyyKUyguZf5pjqvyOOvozXyukT4aXCCmcW05pcjdj1ynF_1wE-78N31yyx9NH5D7GUjSkzSAfXLHdw_J3VRa8vsjcvUlFriBvYzGmDelBIASaB_oh-nsz9WP618UrMdTdG1R0nZ0Zhfl698_Z58onugPtB3osIosE_AWdNnTnNpOEwN0a-mltrbtWk0v28UKOuTkru4xOZu-__rutMjVFgoLyloWXNelL5lz4NBLJ8TYjCfMCV9LW6pxqMfMMDZRgAdq6wFWekCOTgpjPexTtQ78Cdnr-s4fEKpD5W0d9MQyjN-cEQATTeWEdQbwnxwRvp7uxmYqcqyIcdHE72sKQpI0iQ0qqclKGpFi02ueqDhuaf8WNblpi0Ta8QKYV5PNq7nNvEbkAO1g_YChYVwphYVx4P5Ha9u4WfxyI4Yli1rTne9X2KZiEJhJqUbkaTKlzUvGcvacgUTtGNnOKHYlXfst0oKrFD4_-x_DPiT3GB4sxPT0I7K3XKz8c0BfS_MiLrS_NnAw0w
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3NbhMxELZKERIXVH4bWpCRuKGtsl6vvTlUCBBRATUXiNTbyr-wUrQbdpOqPbWvwLPwHjwET8KM90cEBbhm7I3jmfF8453MR8hzlXGdMnBA4RMRceNFpL3kkVKp0A5b8Cu80D-diZM5f3-Wnu2QnrO128Bma2qHfFLzenF08fXyJTj8cWBtkHE_6Wi5VNgQGoKanNwgNyE2SeQ0OOXDewU4sQMZKpLlRDIRovsz3d-eshGsQk9_7IG6qJptePTPssrf4tR0j9zpACZ91VrEXbLjynvkVks5eXmfXH0MxDdwxtGQC7elAqAcWnn6bjr7ef3tx3cKVuUohrwgKUo6M3X8gs4-ULzob2jR0GYdmk_AIuiqol3FO20bQxeGnitjirJQ9Lyo1zChq_kqH5D59O2nNydRR8IQGdDhKkpUFruYWQtxPracj_V4wix3mTCxHPtszDRjEwkwITMO0KYDQGkF18bB8ZUpnzwku2VVun1ClU-dybyaGIZpndUc0KNOLTdWAywUI5L0u52brkM5EmUs8vDaTUKm0u5hjjrKOx2NSDTMWrYdOv4z_jUqchiL_bXDB1X9Oe_cNU-1BJwGYEhZxlViVcy10AB_lfcAgPmI7KMZ9F_Q5CyRUiJfDjz_sDeN7eJngxg8GbWmSletcUzKIF8TQo7Io9aShkUGlvuEgURu2NjGr9iUlMWX0C1ctln1438v64DcZniTEOrRD8nuql67JwC3Vvpp8KBfvFwtRQ
  priority: 102
  providerName: Scholars Portal
Title Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection
URI https://www.ncbi.nlm.nih.gov/pubmed/32023327
https://www.proquest.com/docview/2377705159
https://www.proquest.com/docview/2352049667
https://pubmed.ncbi.nlm.nih.gov/PMC7028289
https://doaj.org/article/5b7976512ad24a3da14b6b045aff5664
http://dx.doi.org/10.1371/journal.ppat.1008279
Volume 16
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3NbtNAEF5BKyQuiP8aSrRI3JBpvF7vOidEUaMCaoSASrlZ-wuWKjvESSVO8Ao8C-_BQ_AkzKw3pkEVXHLIrJW1Z3bmm_HkG0KeqJLrgsEBFD4XKTdepNpLnipVCO2Qgl9hQf9kJo5P-et5MY8Fty62VW58YnDUtjVYIz9guZQSB5JMni8-pzg1Ct-uxhEaV8kuUpehVcv5kHCBfw6jT3E0TipzIeJf53KZHURNPVssFJJIQyDEZq4LoSkw-CPj6VnbXYY-_26ivBCVpjfJjQgn6Yte_7fIFdfcJtf6AZNf7pCv78OYG_BoNGS-fWMAqIK2nr6azn59-_7zBwUbchQDXJDUDZ2ZZfaUzt5QLOt3tO5otw5UE7AJumpp7G-nPQ10bei5MqZuakXP6-UaLogdXs1dcjo9-vDyOI0jF1IDGluluSozlzFrIapnlvOxHk-Y5a4UJpNjX46ZZmwiARSUxgG2dAAfreDaOHBWpfL5PbLTtI3bI1T5wpnSq4lhmMRZzQEr6sJyYzWAQJGQfPO0KxP5yHEsxlkVXrJJyEv6Z1ihjqqoo4Skw1WLno_jP-sPUZHDWmTTDl-0y49VPJxVoSWgMoA-yjKucqsyroUGsKu8B7jLE7KHZrD5ga76Y4wJ2d-YxuXix4MYzi1qTTWuXeOagkF2JoRMyP3ekoZNhpn2OQOJ3LKxrbvYljT1p8ANLvsc-sG_t_WQXGdYNwjd5_tkZ7Vcu0cArlZ6FE7QiOweHs3evhuFEgV8nvDyN5keKt0
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtNAEF6VIgQXxG8bKLBIcEKm9nq96xwQ4i9KSJsLrZSb2T-DpcoOcVLUE7wCL8KF9-AheBJm1nZoUAWnXjNrZ-2ZnflmdzwfIY9UynXCYAGKPBYBN7kIdC55oFQitMMW_Ao39PcnYnjI306T6Qb53n0Lg2WVnU_0jtpWBvfId1kspURCkv7z2acAWaPwdLWj0GjMYuxOPkPKVj8bvQb9PmZs8Obg1TBoWQUCA5NaBLFKIxcxayFwRZbzUId9ZrlLhYlkmKch04z1JcS91DiATw4QkhVcGwfrMVV5DPe9QC5C4A0x2ZPTVYIH8cBTrSIVTyBjIdpP9WIZ7baW8XQ2U9i0GgIvFo-dCoWeMQA7rB5V9Vlo9--izVNRcHCNXG3hK33R2Nt1suHKG-RSQ2h5cpN8eedpdcCDUp9pN4UIoHpa5XQ0mPz6-u3nDwo26ygGVC8pSjox8-gJnYwpHiPUtKhpvfStLWASdFHRtp6eNm2nC0OPlTFFWSh6XMyXcEFbUVbeIofnoozbZLOsSrdNqMoTZ9Jc9Q3DpNFqDthUJ5YbqwF0ih6Ju7edmbb_OdJwHGX-UE9CHtS8wwx1lLU66pFgddWs6f_xn_EvUZGrsdi92_9QzT9krTPIEi0BBQLUUpZxFVsVcS00gGuV5wCveY9soxl0f1Bnf4y_R3Y60zhb_HAlBj-BWlOlq5Y4JmGQDQohe2SrsaTVJGMGyC1mIJFrNrb2FOuSsvjoe5HLJme_8-9pPSCXhwf7e9neaDK-S64w3LPwle87ZHMxX7p7AOwW-r5fTZS8P-_l-xtdv2K5
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwELbKViAuiP8GChgJTijsxnHs7AEhSrvqshBVQKXeUtuxIVKVLJvdop7gFXgWbjwED8GTMJOfpYsqOPW642SdzIznG3syHyGPVMx1xMABhQuFz40TvnaS-0pFQltswa9wQ_9NInb3-auD6GCN_Oi-hcGyym5NrBfqrDS4R95noZQSCUmGfdeWRextj55PP_nIIIUnrR2dRmMiE3vyGdK36tl4G3T9mLHRzvuXu37LMOAbmODcD1Uc2IBlGQSxION8oAdDlnEbCxPIgYsHTDM2lBADY2MBSllAS5ng2ljwzVi5EO57gaxLzIp6ZH1rJ9l728UBiA418SoS8_gyFKL9cC-UQb-1k6fTqcIW1hCGsZTsVGCs-QOw3-pRWZ2Fff8u4TwVE0dXyZUWzNIXjfVdI2u2uE4uNvSWJzfIl3c1yQ6sp7TOu5uyBDAEWjo6HiW_vn77-Z2CBVuK4bWW5AVNzCx4QpMJxUOFiuYVrRZ1owuYBJ2XtK2up00T6tzQY2VMXuSKHuezBVzQ1pcVN8n-uajjFukVZWE3CFUusiZ2amgYppCZ5oBUdZRxk2mAoMIjYfe2U9N2Q0dSjqO0PuKTkBU17zBFHaWtjjziL6-aNt1A_jN-CxW5HIu9vOsfytmHtF0a0khLwIQAvFTGuAozFXAtNEBt5RyAbe6RDTSD7g-q9I8reGSzM42zxQ-XYlg1UGuqsOUCx0QMckMhpEduN5a0nGTIAMeFDCRyxcZWnmJVUuQf687kssng7_x7Wg_IJXDd9PU4mdwllxluYNRl8JukN58t7D1AeXN9v3UnSg7P24N_A9FuaFQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Selective+reconstitution+of+IFN%E2%80%91%CE%B3+gene+function+in+Ncr1%2B+NK+cells+is+sufficient+to+control+systemic+vaccinia+virus+infection&rft.jtitle=PLoS+pathogens&rft.au=Borst%2C+Katharina&rft.au=Flindt%2C+Sven&rft.au=Blank%2C+Patrick&rft.au=Larsen%2C+Pia-Katharina&rft.date=2020-02-01&rft.pub=Public+Library+of+Science&rft.issn=1553-7366&rft.eissn=1553-7374&rft.volume=16&rft.issue=2&rft.spage=e1008279&rft_id=info:doi/10.1371%2Fjournal.ppat.1008279&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7374&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7374&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7374&client=summon