Prognostic Significance of HIF-1α Expression in Hepatocellular Carcinoma: A Meta-Analysis

• Published in: PloS one Vol. 8; no. 6; p. e65753
• Main Authors: Zheng, Su-Su, Chen, Xiao-Hong, Yin, Xin, Zhang, Bo-Heng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.06.2013; Public Library of Science (PLoS)
• Subjects: Biology; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Clinical trials; Confidence intervals; Correlation analysis; Disease-Free Survival; Gene Expression; Hepatitis; Hepatocellular carcinoma; Hospitals; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factors; Literature reviews; Liver cancer; Liver Neoplasms - metabolism; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Medical ethics; Medical prognosis; Medicine; Meta-analysis; Metastases; Metastasis; Patients; Prognosis; Studies; Survival; Tumors

Pilot studies have evaluated the correlation between hypoxia-inducible factor-1α (HIF-1α) overexpression and clinical outcome in hepatocellular carcinoma (HCC) patients. However, the results remain inconclusive. To comprehensively and quantitatively summarize the evidence on the suitability of HIF-1...