Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 42; pp. 13057 - 13062
• Main Authors: Chen, Jung-Tsu, Chen, Chein-Hung, Ku, Ko-Li, Hsiao, Michael, Chiang, Chun-Pin, Hsu, Tsui-Ling, Chen, Min-Huey, Wong, Chi-Huey
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 20.10.2015; National Acad Sciences
• Subjects: B7 Antigens - immunology; B7 Antigens - metabolism; Biological Sciences; Carcinoma, Squamous Cell - immunology; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell Proliferation; Cells; Correlation analysis; Glycoproteins; Glycosylation; Humans; Immune response; Medical diagnosis; Molecules; Mouth Neoplasms - immunology; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Oral cancer; Survival; fucose; proliferation; glycan sequencing; terminal α-galactose; CD276

The incidence and mortality rate of oral cancer continue to rise, partly due to the lack of effective early diagnosis and increasing environmental exposure to cancer-causing agents. To identify new markers for oral cancer, we used a sialylation probe to investigate the glycoproteins differentially e...