Reduced Virulence of an fliC Mutant of Shiga-Toxigenic Escherichia coli O113:H21

• Published in: Infection and Immunity Vol. 74; no. 3; pp. 1962 - 1966
• Main Authors: Rogers, Trisha J, Paton, James C, Wang, Hui, Talbot, Ursula M, Paton, Adrienne W
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2006
• Subjects: Animals; Bacteriology; Biological and medical sciences; Escherichia coli; Escherichia coli - genetics; Escherichia coli - immunology; Escherichia coli - pathogenicity; Escherichia coli Infections - etiology; Flagellin - genetics; Flagellin - metabolism; Fundamental and applied biological sciences. Psychology; Mice; Microbiology; Miscellaneous; Molecular Pathogenesis; Mutation; Shiga Toxins - genetics; Streptomycin - pharmacology; Virulence - genetics; Microbiology; Escherichia coli; Virulence; Bacteria; Mutation; Immunity; Enterobacteriaceae

The contribution of flagellin to the virulence of the O113:H21 Shiga-toxigenic Escherichia coli (STEC) strain 98NK2 was investigated in the streptomycin-treated mouse model. Groups of mice were challenged with either the wild-type STEC or a fliC deletion derivative thereof. There was no difference i...