GSK3β inhibition and canonical Wnt signaling in mice hearts after myocardial ischemic damage

• Published in: PloS one Vol. 14; no. 6; p. e0218098
• Main Authors: Badimon, Lina, Casaní, Laura, Camino-Lopez, Sandra, Juan-Babot, Oriol, Borrell-Pages, Maria
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.06.2019; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Cardiac function; Congestive heart failure; Damage assessment; Gene Expression; Glycogen Synthase Kinase 3 beta - antagonists & inhibitors; Heart attacks; Heart failure; Inhibitors; Injuries; Ischemia; Kinases; Ligands; Low Density Lipoprotein Receptor-Related Protein-5 - genetics; LRP5 protein; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial infarction; Myocardial Ischemia - drug therapy; Myocardial Ischemia - enzymology; Myocardial Ischemia - metabolism; Myocardial Ischemia - pathology; Myocardium - enzymology; Myocardium - metabolism; Permeability; Phosphorylation; Protein Kinase Inhibitors - pharmacology; Proteins; Pyridines - therapeutic use; Pyrimidines - therapeutic use; Research and Analysis Methods; Rodents; Salvage; Signal transduction; Signaling; Vascular endothelial growth factor; Wnt protein; Wnt Signaling Pathway - genetics; Spain

Myocardial infarction induces myocardial injury and tissue damage. During myocardial infarction strong cellular response is initiated to salvage the damaged tissues. This response is associated with the induction of different signaling pathways. Of these, the canonical Wnt signaling is increasingly...