Critical review of acylation-stimulating protein physiology in humans and rodents

• Published in: BBA - Biomembranes Vol. 1609; no. 2; pp. 127 - 143
• Main Authors: Cianflone, Katherine, Xia, Zhunan, Chen, Lan Ying
• Format: Book Review Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 31.01.2003
• Subjects: Adipose Tissue - metabolism; Animals; Blood Proteins - deficiency; Blood Proteins - physiology; Body Weight; C3adesArg; CAD; Cardiovascular Diseases - metabolism; Complement C3; Complement C3 - metabolism; Complement C3 - physiology; Complement C3a - analogs & derivatives; Complement Factor B - metabolism; Complement Factor B - physiology; Complement Factor D; Diabetes; Diabetes Mellitus - metabolism; Humans; Hyperlipidemias - metabolism; Insulin Resistance; Leptin - blood; Leptin - metabolism; Mice; Mice, Knockout; Models, Animal; Obesity; Obesity - metabolism; Postprandial Period; Rats; Serine Endopeptidases - metabolism; Serine Endopeptidases - physiology; Triglycerides - blood; Triglycerides - metabolism; Obesity; FCHL; KO; Complement C3; CAD; PLD; AUC; CVF; FIAT; NEFA; Diabetes; ASP; C3adesArg; BMI; TZD

In the last few years, there has been increasing interest in the physiological role of acylation-stimulating protein (ASP). Recent studies in rats and mice, in particular in C3 (−/−) mice that are ASP deficient, have advanced our understanding of the role of ASP. Of note, the background strain of th...