Untargeted lipidomic analysis to broadly characterize the effects of pathogenic and non-pathogenic staphylococci on mammalian lipids

• Published in: PloS one Vol. 13; no. 10; p. e0206606
• Main Authors: Gajenthra Kumar, Naren, Contaifer, Daniel, Baker, Paul RS, Ekroos, Kim, Jefferson, Kimberly K., Wijesinghe, Dayanjan S.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.10.2018; Public Library of Science (PLoS)
• Subjects: Animals; Antibacterial agents; Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; Bacteria; Bacterial diseases; Biology and Life Sciences; Cattle; Clinical isolates; Drug therapy; Endocarditis; Enzymes; Fatty acids; Glycerol; Immunology; Infections; Internet; Lipid metabolism; Lipid Metabolism - physiology; Lipids; Mammals; Mass spectrometry; Medicine and Health Sciences; Metabolism; Myocardium - metabolism; Pathogenesis; Pharmacy; Scientific imaging; Species; Staphylococcus - metabolism; Staphylococcus aureus; Staphylococcus infections; Strains (organisms); Virulence; United States > US; Virginia

Modification of the host lipidome via secreted enzymes is an integral, but often overlooked aspect of bacterial pathogenesis. In the current era of prevalent antibiotic resistance, knowledge regarding critical host pathogen lipid interactions has the potential for use in developing novel antibacteri...