Tubastatin A potently inhibits GPX4 activity to potentiate cancer radiotherapy through boosting ferroptosis

• Published in: Redox biology Vol. 62; p. 102677
• Main Authors: Liu, Shan, Zhang, Hai-Liang, Li, Jing, Ye, Zhi-Peng, Du, Tian, Li, Li-Chao, Guo, Yi-Qing, Yang, Dong, Li, Zhi-Ling, Cao, Jiang-Hua, Hu, Bing-Xin, Chen, Yu-Hong, Feng, Gong-Kan, Li, Zhi-Ming, Deng, Rong, Huang, Jia-Jia, Zhu, Xiao-Feng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2023; Elsevier
• Subjects: Animals; Apoptosis; Ferroptosis; Humans; Lipid Peroxidation; Mice; Neoplasms; Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism; Research Paper

Ferroptosis, an iron-dependent lipid peroxidation-driven programmed cell death, is closely related to cancer therapy. The development of druggable ferroptosis inducers and their rational application in cancer therapy are critical. Here, we identified Tubastatin A, an HDAC6 inhibitor as a novel drugg...