Determinants of two-year mortality among HIV positive patients with Cryptococcal meningitis initiating standard antifungal treatment with or without adjunctive dexamethasone in Uganda

• Published in: PLoS neglected tropical diseases Vol. 14; no. 11; p. e0008823
• Main Authors: Kitonsa, Jonathan, Nsubuga, Rebecca, Mayanja, Yunia, Kiwanuka, Julius, Nikweri, Yofesi, Onyango, Martin, Anywaine, Zacchaeus, Ggayi, Abu-Baker, Kibengo, Freddie Mukasa, Kaleebu, Pontiano, Day, Jeremy
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2020; Public Library of Science (PLoS)
• Subjects: Adult; AIDS-Related Opportunistic Infections - drug therapy; AIDS-Related Opportunistic Infections - mortality; Amphotericin B; Amphotericin B - therapeutic use; Anti-Inflammatory Agents - therapeutic use; Antifungal agents; Antifungal Agents - therapeutic use; Antigens; Antiretroviral drugs; Antiretroviral therapy; Biology and Life Sciences; Blindness; Blood; Blood cells; Body Weight; Cell culture; Cerebrospinal fluid; Cohort Studies; Coma; Convulsions; Data collection; Demographic variables; Dexamethasone; Dexamethasone - therapeutic use; Ears; Eye (anatomy); Female; Fever; Fluconazole; Fluconazole - therapeutic use; Fungal infections; Fungi; Fungicides; Gender; Health services; Hearing; Hearing loss; HIV; Hospitals; Human immunodeficiency virus; Humans; Hygiene; Intravenous administration; Leukocytes; Male; Medical research; Medical sciences; Medicine; Medicine and Health Sciences; Meningitis; Meningitis, Cryptococcal - drug therapy; Meningitis, Cryptococcal - mortality; Mortality; Patients; Placebos; Questionnaires; Randomization; Research facilities; Retrospective Studies; Risk Factors; Seizures; Steroids; Stiffness; Therapy; Tropical climate; Tropical diseases; Uganda; Variables; Viruses; White blood cells; Yeast; Yeasts; Uganda; Africa

Globally, early initiation of antiretroviral therapy for HIV led to a reduction in the estimated mortality from cryptococcal meningitis (CCM) from 624,700 in 2009 to 181,100 in 2014. However, CCM remains one of the leading causes of mortality among HIV infected patients especially in sub-Saharan Afr...